YDL026W_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL026W / YDL026W

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.65|P-value:2.00E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.22|P-value:1.15E-15 ID:SGTC_122|Compound:0236-0016|FD-Score:3.63|P-value:2.36E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.42|P-value:1.03E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:4.55|P-value:5.89E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.25|P-value:8.80E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.29|P-value:7.04E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.21|P-value:9.26E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.54|P-value:3.00E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.36|P-value:6.16E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.68|P-value:1.97E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.21|P-value:2.50E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.35|P-value:6.32E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.56|P-value:3.09E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.34|P-value:5.99E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.15|P-value:3.21E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:-4.06|P-value:4.24E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.28|P-value:1.89E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.39|P-value:5.49E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.83|P-value:9.43E-9 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.60|P-value:2.68E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.40|P-value:5.38E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.29|P-value:7.86E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.20|P-value:9.72E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.68|P-value:1.99E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.23|P-value:9.54E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.61|P-value:2.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.39|P-value:1.18E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.33|P-value:6.88E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.28|P-value:7.95E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.45|P-value:4.14E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.04|P-value:5.10E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.79|P-value:1.19E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.22|P-value:9.67E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.27|P-value:8.17E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.03|P-value:4.69E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-5.68|P-value:1.93E-8 ID:SGTC_2868|Compound:9035608|FD-Score:-3.31|P-value:6.70E-4 ID:SGTC_2918|Compound:7977171|FD-Score:5.73|P-value:1.70E-8 ID:SGTC_2925|Compound:9010536|FD-Score:4.93|P-value:1.00E-6 ID:SGTC_2999|Compound:9069765|FD-Score:4.79|P-value:1.95E-6 ID:SGTC_3098|Compound:9119039|FD-Score:3.76|P-value:1.45E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.59|P-value:2.52E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.65|P-value:2.00E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.22|P-value:1.15E-15 ID:SGTC_122|Compound:0236-0016|FD-Score:3.63|P-value:2.36E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.42|P-value:1.03E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:4.55|P-value:5.89E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.25|P-value:8.80E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.29|P-value:7.04E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.21|P-value:9.26E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.54|P-value:3.00E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.36|P-value:6.16E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.68|P-value:1.97E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.21|P-value:2.50E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.35|P-value:6.32E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.56|P-value:3.09E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.34|P-value:5.99E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.15|P-value:3.21E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:-4.06|P-value:4.24E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.28|P-value:1.89E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.39|P-value:5.49E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.83|P-value:9.43E-9 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.60|P-value:2.68E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.40|P-value:5.38E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.29|P-value:7.86E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.20|P-value:9.72E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.68|P-value:1.99E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.23|P-value:9.54E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.61|P-value:2.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.39|P-value:1.18E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.33|P-value:6.88E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.28|P-value:7.95E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.45|P-value:4.14E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.04|P-value:5.10E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.79|P-value:1.19E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.22|P-value:9.67E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.27|P-value:8.17E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.03|P-value:4.69E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-5.68|P-value:1.93E-8 ID:SGTC_2868|Compound:9035608|FD-Score:-3.31|P-value:6.70E-4 ID:SGTC_2918|Compound:7977171|FD-Score:5.73|P-value:1.70E-8 ID:SGTC_2925|Compound:9010536|FD-Score:4.93|P-value:1.00E-6 ID:SGTC_2999|Compound:9069765|FD-Score:4.79|P-value:1.95E-6 ID:SGTC_3098|Compound:9119039|FD-Score:3.76|P-value:1.45E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.59|P-value:2.52E-4

Top fitness defect scores for YDL026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_69 0096-0274 8.22 206.7 µM 1.15E-15 mitochondrial processes 3 1.04E-16
2 SGTC_1346 1488-2224 5.83 62.4 µM 9.43E-9 7 2.70E-9
3 SGTC_2592 piperlongumine 5.79 83.3 µM 1.19E-8 TSC3-RPN4 8 3.48E-9
4 SGTC_2918 7977171 5.73 22.1 µM 1.70E-8 5 5.07E-9
5 SGTC_2925 9010536 4.93 32.5 µM 1.00E-6 azole & statin 25 4.03E-7
6 SGTC_2999 9069765 4.79 71.4 µM 1.95E-6 amide catabolism 9 8.23E-7
7 SGTC_196 k015-0023 4.55 18.1 µM 5.89E-6 PDR1 13 2.69E-6
8 SGTC_143 4032-1194 4.42 15.7 µM 1.03E-5 44 4.89E-6
9 SGTC_1926 methyl fluorone black 4.39 53.6 µM 1.18E-5 DNA intercalators 48 5.65E-6
10 SGTC_1207 2099-0101 4.28 141.0 µM 1.89E-5 10 9.40E-6
11 SGTC_2638 epoxomicin 4.24 18.0 µM 2.26E-5 25 1.13E-5
12 SGTC_457 grayanotoxin iii 4.21 135.0 µM 2.50E-5 55 1.27E-5
13 SGTC_1140 3229-1848 4.15 3.0 µM 3.21E-5 7 1.66E-5
14 SGTC_2358 9037157 4.04 4.0 µM 5.10E-5 29 2.72E-5
15 SGTC_3098 9119039 3.76 49.5 µM 1.45E-4 Golgi 39 8.35E-5
16 SGTC_453 enantio-paf c16 3.68 10.0 µM 1.97E-4 167 1.16E-4
17 SGTC_1784 st039334 3.68 36.3 µM 1.99E-4 26 1.17E-4
18 SGTC_122 0236-0016 3.63 402.4 µM 2.36E-4 RNA processing & uracil transport 45 1.40E-4
19 SGTC_1379 2144-0755 3.60 36.5 µM 2.68E-4 33 1.61E-4
20 SGTC_669 0108-0021 3.56 26.2 µM 3.09E-4 fatty acid desaturase (OLE1) 107 1.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.23E-14 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.125 3.96E-13 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.110 1.52E-10 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.102 2.75E-9 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.101 5.16E-9 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.100 6.94E-9 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.097 1.76E-8 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.097 1.94E-8 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.096 2.68E-8 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.094 4.84E-8 YOR334W MRS2 hom Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
0.093 6.29E-8 YOL073C YOL073C hom Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2
0.093 6.85E-8 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.093 6.82E-8 YDR255C RMD5 hom Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain
0.093 7.31E-8 YOL101C IZH4 hom Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress
0.092 8.91E-8 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon