YDL027C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL027C / YDL027C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.21|P-value:7.53E-6 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.26|P-value:3.60E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.12|P-value:6.07E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.22|P-value:4.67E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:5.27|P-value:2.93E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.10|P-value:7.21E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.17|P-value:5.60E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.81|P-value:3.12E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:3.89|P-value:3.15E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:4.12|P-value:1.11E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.05|P-value:8.57E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:7.98|P-value:1.01E-16 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.63|P-value:8.18E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.77|P-value:5.34E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.46|P-value:1.89E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.25|P-value:4.20E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.67|P-value:8.18E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.03|P-value:9.33E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.56|P-value:1.24E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.26|P-value:5.89E-6 ID:SGTC_2025|Compound:5147754|FD-Score:3.75|P-value:5.72E-5 ID:SGTC_2040|Compound:5100729|FD-Score:-3.06|P-value:7.42E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-5.92|P-value:4.47E-10 ID:SGTC_2107|Compound:5363541|FD-Score:4.78|P-value:4.25E-7 ID:SGTC_2121|Compound:5257820|FD-Score:3.25|P-value:4.22E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.13|P-value:6.50E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.02|P-value:9.69E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.35|P-value:3.89E-6 ID:SGTC_2393|Compound:9031399|FD-Score:-3.09|P-value:6.68E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.08|P-value:1.33E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.59|P-value:3.62E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.07|P-value:1.39E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.11|P-value:7.10E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.48|P-value:1.98E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.34|P-value:2.94E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.06|P-value:8.30E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.14|P-value:5.67E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.14|P-value:8.90E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.94|P-value:2.20E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.70|P-value:6.99E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.68|P-value:7.87E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.29|P-value:3.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.08|P-value:7.85E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.57|P-value:1.21E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.21|P-value:7.53E-6 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.26|P-value:3.60E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.12|P-value:6.07E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.22|P-value:4.67E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:5.27|P-value:2.93E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.10|P-value:7.21E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.17|P-value:5.60E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.81|P-value:3.12E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:3.89|P-value:3.15E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:4.12|P-value:1.11E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.05|P-value:8.57E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:7.98|P-value:1.01E-16 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.63|P-value:8.18E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.77|P-value:5.34E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.46|P-value:1.89E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.25|P-value:4.20E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.67|P-value:8.18E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.03|P-value:9.33E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.56|P-value:1.24E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.26|P-value:5.89E-6 ID:SGTC_2025|Compound:5147754|FD-Score:3.75|P-value:5.72E-5 ID:SGTC_2040|Compound:5100729|FD-Score:-3.06|P-value:7.42E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-5.92|P-value:4.47E-10 ID:SGTC_2107|Compound:5363541|FD-Score:4.78|P-value:4.25E-7 ID:SGTC_2121|Compound:5257820|FD-Score:3.25|P-value:4.22E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.13|P-value:6.50E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.02|P-value:9.69E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.35|P-value:3.89E-6 ID:SGTC_2393|Compound:9031399|FD-Score:-3.09|P-value:6.68E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.08|P-value:1.33E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.59|P-value:3.62E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.07|P-value:1.39E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.11|P-value:7.10E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.48|P-value:1.98E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.34|P-value:2.94E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.06|P-value:8.30E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.14|P-value:5.67E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.14|P-value:8.90E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.94|P-value:2.20E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.70|P-value:6.99E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.68|P-value:7.87E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.29|P-value:3.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.08|P-value:7.85E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.57|P-value:1.21E-4

Top fitness defect scores for YDL027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1376 2910-0861 7.98 41.3 µM 1.01E-16 2 7.40E-16
2 SGTC_155 k072-0202 5.27 43.6 µM 2.93E-8 8 6.89E-8
3 SGTC_2107 5363541 4.78 170.2 µM 4.25E-7 3 8.59E-7
4 SGTC_2552 juarezic acid 4.48 87.0 µM 1.98E-6 TSC3-RPN4 23 3.66E-6
5 SGTC_2338 7999974 4.35 200.0 µM 3.89E-6 12 6.93E-6
6 SGTC_1936 st074407 4.26 74.3 µM 5.89E-6 DNA damage response 27 1.03E-5
7 SGTC_6 0844-0013 4.21 19.8 µM 7.53E-6 70 1.29E-5
8 SGTC_998 3996-0085 4.12 177.0 µM 1.11E-5 14 1.86E-5
9 SGTC_1125 tnp00248 4.11 1.3 µM 1.16E-5 21 1.95E-5
10 SGTC_2396 5342950 4.08 42.8 µM 1.33E-5 RSC complex & mRNA processing 39 2.22E-5
11 SGTC_2408 sulbentine 4.07 18.4 µM 1.39E-5 45 2.31E-5
12 SGTC_1156 4092-0367 3.91 4.9 µM 2.90E-5 20 4.62E-5
13 SGTC_764 1951-2361 3.89 146.0 µM 3.15E-5 39 5.00E-5
14 SGTC_1495 4469-0029 3.77 237.0 µM 5.34E-5 120 8.23E-5
15 SGTC_2025 5147754 3.75 141.0 µM 5.72E-5 12 8.78E-5
16 SGTC_2976 9009005 3.70 19.5 µM 6.99E-5 33 1.06E-4
17 SGTC_2978 9011784 3.68 43.0 µM 7.87E-5 40 1.19E-4
18 SGTC_1652 st011932 3.67 78.0 µM 8.18E-5 RSC complex & mRNA processing 15 1.23E-4
19 SGTC_3212 9128307 3.57 49.5 µM 1.21E-4 64 1.78E-4
20 SGTC_1876 myriocin 3.56 605.0 nM 1.24E-4 46 1.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.41E-20 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.153 5.66E-19 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.130 3.80E-14 YFL047W RGD2 hom GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.128 8.23E-14 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.124 5.01E-13 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.124 5.62E-13 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.123 7.14E-13 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.123 7.66E-13 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.123 9.86E-13 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.122 1.60E-12 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.120 3.00E-12 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.119 4.43E-12 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.118 7.39E-12 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.115 2.08E-11 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.114 3.75E-11 YDL036C PUS9 hom Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence