HIPHOP chemogenomics database
YDL032W_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDL032W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.483 | 3.30E-196 | YDR518W | EUG1 | hom | Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER |
| 0.474 | 9.65E-188 | YDR231C | COX20 | hom | Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase |
| 0.469 | 1.16E-183 | YDR533C | HSP31 | hom | Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress |
| 0.457 | 5.79E-173 | YDR079W | PET100 | hom | Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme |
| 0.456 | 8.62E-172 | YDR237W | MRPL7 | hom | Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein |
| 0.451 | 6.97E-168 | YOR330C | MIP1 | hom | Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit |
| 0.451 | 7.03E-168 | YGR220C | MRPL9 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.447 | 3.72E-164 | YNL213C | RRG9 | hom | Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.445 | 6.25E-163 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
| 0.443 | 1.67E-161 | YPL132W | COX11 | hom | Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p |
| 0.442 | 2.48E-160 | YML129C | COX14 | hom | Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes |
| 0.439 | 2.96E-158 | YKL068W-A_p | YKL068W-A_p | hom | Putative protein of unknown function; identified by homology to Ashbya gossypii |
| 0.436 | 1.51E-155 | YGR150C | CCM1 | hom | Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport |
| 0.435 | 1.12E-154 | YCR024C | SLM5 | hom | Mitochondrial asparaginyl-tRNA synthetase |
| 0.434 | 2.03E-154 | YNL252C | MRPL17 | hom | Mitochondrial ribosomal protein of the large subunit |