YDL032W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL032W / YDL032W

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.71|P-value:2.77E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.31|P-value:2.40E-15 ID:SGTC_72|Compound:0744-0168|FD-Score:4.28|P-value:3.26E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.50|P-value:5.79E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.43|P-value:1.76E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:15.10|P-value:1.11E-46 ID:SGTC_149|Compound:3970-0822|FD-Score:4.30|P-value:3.02E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.19|P-value:9.30E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.67|P-value:6.27E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.07|P-value:7.44E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:5.31|P-value:3.29E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:12.00|P-value:3.49E-30 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.12|P-value:4.15E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:4.66|P-value:6.61E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:7.82|P-value:8.84E-14 ID:SGTC_462|Compound:ag-879|FD-Score:4.32|P-value:2.73E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.16|P-value:6.85E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:7.35|P-value:2.37E-12 ID:SGTC_811|Compound:0416-0114|FD-Score:4.34|P-value:2.57E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:4.23|P-value:3.89E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.36|P-value:9.15E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.50|P-value:3.32E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.80|P-value:1.09E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.67|P-value:1.81E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.39|P-value:8.13E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.21|P-value:8.62E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-4.68|P-value:2.93E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.38|P-value:8.35E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.29|P-value:3.08E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.37|P-value:5.19E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.91|P-value:1.36E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.02|P-value:9.08E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.40|P-value:2.01E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.39|P-value:8.17E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.34|P-value:9.69E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.93|P-value:1.26E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.69|P-value:2.94E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.70|P-value:2.91E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.89|P-value:4.60E-11 ID:SGTC_1657|Compound:st012939|FD-Score:-3.51|P-value:3.14E-4 ID:SGTC_1674|Compound:st016616|FD-Score:8.79|P-value:6.04E-17 ID:SGTC_1683|Compound:st010134|FD-Score:3.84|P-value:1.74E-4 ID:SGTC_1742|Compound:st038235|FD-Score:8.20|P-value:5.57E-15 ID:SGTC_1745|Compound:st081495|FD-Score:3.47|P-value:6.29E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.30|P-value:2.94E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.84|P-value:1.74E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.60|P-value:8.58E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.18|P-value:9.58E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.73|P-value:2.60E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.62|P-value:6.85E-8 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.63|P-value:6.58E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.81|P-value:3.39E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-4.16|P-value:2.73E-5 ID:SGTC_2885|Compound:9057732|FD-Score:6.05|P-value:6.79E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-6.39|P-value:3.77E-10 ID:SGTC_2932|Compound:9016711|FD-Score:8.28|P-value:3.16E-15 ID:SGTC_2934|Compound:9036370|FD-Score:6.61|P-value:2.63E-10 ID:SGTC_2936|Compound:9038235|FD-Score:6.01|P-value:8.33E-9 ID:SGTC_3004|Compound:9076122|FD-Score:3.64|P-value:3.60E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.65|P-value:1.91E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.50|P-value:1.29E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.17|P-value:5.02E-5 ID:SGTC_3210|Compound:9128157|FD-Score:5.53|P-value:1.06E-7 ID:SGTC_38|Compound:0929-0051|FD-Score:3.71|P-value:2.77E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.31|P-value:2.40E-15 ID:SGTC_72|Compound:0744-0168|FD-Score:4.28|P-value:3.26E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.50|P-value:5.79E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.43|P-value:1.76E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:15.10|P-value:1.11E-46 ID:SGTC_149|Compound:3970-0822|FD-Score:4.30|P-value:3.02E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.19|P-value:9.30E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.67|P-value:6.27E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.07|P-value:7.44E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:5.31|P-value:3.29E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:12.00|P-value:3.49E-30 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.12|P-value:4.15E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:4.66|P-value:6.61E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:7.82|P-value:8.84E-14 ID:SGTC_462|Compound:ag-879|FD-Score:4.32|P-value:2.73E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.16|P-value:6.85E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:7.35|P-value:2.37E-12 ID:SGTC_811|Compound:0416-0114|FD-Score:4.34|P-value:2.57E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:4.23|P-value:3.89E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.36|P-value:9.15E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.50|P-value:3.32E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.80|P-value:1.09E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.67|P-value:1.81E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.39|P-value:8.13E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.21|P-value:8.62E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-4.68|P-value:2.93E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.38|P-value:8.35E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.29|P-value:3.08E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.37|P-value:5.19E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.91|P-value:1.36E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.02|P-value:9.08E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.40|P-value:2.01E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.39|P-value:8.17E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.34|P-value:9.69E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.93|P-value:1.26E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.69|P-value:2.94E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.70|P-value:2.91E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.89|P-value:4.60E-11 ID:SGTC_1657|Compound:st012939|FD-Score:-3.51|P-value:3.14E-4 ID:SGTC_1674|Compound:st016616|FD-Score:8.79|P-value:6.04E-17 ID:SGTC_1683|Compound:st010134|FD-Score:3.84|P-value:1.74E-4 ID:SGTC_1742|Compound:st038235|FD-Score:8.20|P-value:5.57E-15 ID:SGTC_1745|Compound:st081495|FD-Score:3.47|P-value:6.29E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.30|P-value:2.94E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.84|P-value:1.74E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.60|P-value:8.58E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.18|P-value:9.58E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.73|P-value:2.60E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.62|P-value:6.85E-8 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.63|P-value:6.58E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.81|P-value:3.39E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-4.16|P-value:2.73E-5 ID:SGTC_2885|Compound:9057732|FD-Score:6.05|P-value:6.79E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-6.39|P-value:3.77E-10 ID:SGTC_2932|Compound:9016711|FD-Score:8.28|P-value:3.16E-15 ID:SGTC_2934|Compound:9036370|FD-Score:6.61|P-value:2.63E-10 ID:SGTC_2936|Compound:9038235|FD-Score:6.01|P-value:8.33E-9 ID:SGTC_3004|Compound:9076122|FD-Score:3.64|P-value:3.60E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.65|P-value:1.91E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.50|P-value:1.29E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.17|P-value:5.02E-5 ID:SGTC_3210|Compound:9128157|FD-Score:5.53|P-value:1.06E-7

Top fitness defect scores for YDL032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 15.10 6.9 µM 1.11E-46 16 6.84E-52
2 SGTC_236 1509-0011 12.00 5.3 µM 3.49E-30 150 1.45E-33
3 SGTC_275 trichlorophene 9.12 5.7 µM 4.15E-18 mitochondrial stress 55 3.91E-20
4 SGTC_1674 st016616 8.79 23.6 µM 6.04E-17 1 7.72E-19
5 SGTC_70 0141-0289 8.31 43.3 µM 2.40E-15 mitochondrial stress 36 4.65E-17
6 SGTC_2932 9016711 8.28 44.5 µM 3.16E-15 7 6.33E-17
7 SGTC_1742 st038235 8.20 28.9 µM 5.57E-15 mitochondrial stress 20 1.19E-16
8 SGTC_386 1509-0011 7.82 3.1 µM 8.84E-14 68 2.59E-15
9 SGTC_795 0685-0265 7.35 78.0 µM 2.37E-12 excess fatty acid 5 1.01E-13
10 SGTC_1635 st007035 6.89 42.4 µM 4.60E-11 120 2.76E-12
11 SGTC_2934 9036370 6.61 36.9 µM 2.63E-10 8 1.93E-11
12 SGTC_2885 9057732 6.05 52.0 µM 6.79E-9 3 7.26E-10
13 SGTC_2936 9038235 6.01 15.6 µM 8.33E-9 2 9.13E-10
14 SGTC_2501 sodium tetradecyl sulfate 5.63 13.4 µM 6.58E-8 9 9.18E-9
15 SGTC_2499 avocadenofuran 5.62 51.5 µM 6.85E-8 11 9.59E-9
16 SGTC_3210 9128157 5.53 49.5 µM 1.06E-7 18 1.56E-8
17 SGTC_214 4373-3496 5.31 70.0 µM 3.29E-7 20 5.53E-8
18 SGTC_767 0929-0023 5.16 86.0 µM 6.85E-7 TRP & mitochondrial translation 30 1.26E-7
19 SGTC_2688 kanamycin b 4.81 96.7 µM 3.39E-6 calcium & mitochondrial duress 264 7.50E-7
20 SGTC_168 3970-0862 4.67 530.5 µM 6.27E-6 82 1.49E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.483 3.30E-196 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.474 9.65E-188 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.469 1.16E-183 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.457 5.79E-173 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.456 8.62E-172 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.451 6.97E-168 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.451 7.03E-168 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.447 3.72E-164 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.445 6.25E-163 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.443 1.67E-161 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.442 2.48E-160 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.439 2.96E-158 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.436 1.51E-155 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.435 1.12E-154 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.434 2.03E-154 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit