YDL034W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL034W / YDL034W

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-3.57|P-value:1.03E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:4.30|P-value:3.89E-6 ID:SGTC_213|Compound:1246-0773|FD-Score:3.92|P-value:2.26E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.39|P-value:2.08E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.73|P-value:5.35E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.09|P-value:6.43E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.20|P-value:4.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.23|P-value:5.53E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.37|P-value:2.24E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.49|P-value:1.50E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.38|P-value:2.22E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.02|P-value:8.53E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.30|P-value:3.02E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.12|P-value:5.85E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.62|P-value:8.21E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.24|P-value:3.80E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.28|P-value:3.19E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.00|P-value:1.63E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.75|P-value:4.75E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.09|P-value:6.50E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.19|P-value:4.49E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.24|P-value:3.72E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.13|P-value:5.63E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.89|P-value:2.62E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.23|P-value:3.92E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-3.71|P-value:5.58E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.19|P-value:4.59E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.24|P-value:3.82E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-3.13|P-value:5.58E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.84|P-value:3.29E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.12|P-value:5.85E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.17|P-value:4.92E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.43|P-value:1.83E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.08|P-value:6.27E-8 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.37|P-value:2.31E-4 ID:SGTC_2966|Compound:9084041|FD-Score:6.56|P-value:4.56E-12 ID:SGTC_3075|Compound:9116269|FD-Score:4.03|P-value:1.37E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-4.34|P-value:3.15E-6 ID:SGTC_3110|Compound:9122132|FD-Score:-5.01|P-value:9.20E-8 ID:SGTC_3206|Compound:9114350|FD-Score:-3.88|P-value:2.73E-5 ID:SGTC_3292|Compound:9120825|FD-Score:3.15|P-value:5.23E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.48|P-value:1.62E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.57|P-value:1.03E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:4.30|P-value:3.89E-6 ID:SGTC_213|Compound:1246-0773|FD-Score:3.92|P-value:2.26E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.39|P-value:2.08E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.73|P-value:5.35E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.09|P-value:6.43E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.20|P-value:4.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.23|P-value:5.53E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.37|P-value:2.24E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.49|P-value:1.50E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.38|P-value:2.22E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.02|P-value:8.53E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.30|P-value:3.02E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.12|P-value:5.85E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.62|P-value:8.21E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.24|P-value:3.80E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.28|P-value:3.19E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.00|P-value:1.63E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.75|P-value:4.75E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.09|P-value:6.50E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.19|P-value:4.49E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.24|P-value:3.72E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.13|P-value:5.63E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.89|P-value:2.62E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.23|P-value:3.92E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-3.71|P-value:5.58E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.19|P-value:4.59E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.24|P-value:3.82E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-3.13|P-value:5.58E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.84|P-value:3.29E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.12|P-value:5.85E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.17|P-value:4.92E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.43|P-value:1.83E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.08|P-value:6.27E-8 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.37|P-value:2.31E-4 ID:SGTC_2966|Compound:9084041|FD-Score:6.56|P-value:4.56E-12 ID:SGTC_3075|Compound:9116269|FD-Score:4.03|P-value:1.37E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-4.34|P-value:3.15E-6 ID:SGTC_3110|Compound:9122132|FD-Score:-5.01|P-value:9.20E-8 ID:SGTC_3206|Compound:9114350|FD-Score:-3.88|P-value:2.73E-5 ID:SGTC_3292|Compound:9120825|FD-Score:3.15|P-value:5.23E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.48|P-value:1.62E-6

Top fitness defect scores for YDL034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2966 9084041 6.56 48.0 µM 4.56E-12 4 2.73E-11
2 SGTC_2514 salinomycin 5.08 42.7 µM 6.27E-8 22 1.86E-7
3 SGTC_473 2-arachidonoylglycerol 4.49 10.0 µM 1.50E-6 16 3.54E-6
4 SGTC_3293 9120939 4.48 62.0 µM 1.62E-6 9 3.79E-6
5 SGTC_155 k072-0202 4.30 43.6 µM 3.89E-6 13 8.55E-6
6 SGTC_453 enantio-paf c16 4.23 10.0 µM 5.53E-6 125 1.18E-5
7 SGTC_3075 9116269 4.03 49.5 µM 1.37E-5 19 2.74E-5
8 SGTC_1147 3809-1045 4.00 12.3 µM 1.63E-5 23 3.23E-5
9 SGTC_213 1246-0773 3.92 967.0 nM 2.26E-5 21 4.38E-5
10 SGTC_1806 st050005 3.89 60.3 µM 2.62E-5 9 5.02E-5
11 SGTC_2107 5363541 3.84 170.2 µM 3.29E-5 10 6.19E-5
12 SGTC_1156 4092-0367 3.75 4.9 µM 4.75E-5 28 8.72E-5
13 SGTC_361 000s-0510 3.73 1.4 µM 5.35E-5 36 9.74E-5
14 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.43 3.7 µM 1.83E-4 135 3.05E-4
15 SGTC_270 tamoxifen 3.39 5.5 µM 2.08E-4 NEO1 57 3.43E-4
16 SGTC_734 2023-0417 3.38 80.0 µM 2.22E-4 ergosterol biosynthesis 36 3.64E-4
17 SGTC_2524 avocatin b 3.37 10.6 µM 2.31E-4 39 3.79E-4
18 SGTC_892 0929-0076 3.30 29.0 µM 3.02E-4 TRP & mitochondrial translation 75 4.86E-4
19 SGTC_1104 tacrolimus 3.28 29.8 µM 3.19E-4 58 5.12E-4
20 SGTC_2316 5844804 3.28 197.4 µM 3.23E-4 67 5.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.20E-13 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.07E-12 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.118 7.75E-12 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.114 4.34E-11 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.113 4.38E-11 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.106 7.77E-10 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.101 3.98E-9 YDL027C_p YDL027C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
0.099 9.46E-9 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.096 2.57E-8 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.094 5.58E-8 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.092 8.99E-8 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.090 1.95E-7 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.088 3.47E-7 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.087 4.00E-7 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.086 5.82E-7 YHL030W ECM29 hom Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress