YDL035C / GPR1

Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL035C / GPR1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:5.71|P-value:1.19E-7 ID:SGTC_21|Compound:0849-0113|FD-Score:3.47|P-value:8.65E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.93|P-value:1.89E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.50|P-value:2.17E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:4.69|P-value:1.13E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.73|P-value:3.71E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.26|P-value:5.78E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.81|P-value:2.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.60|P-value:1.58E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-3.49|P-value:7.53E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.84|P-value:2.62E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.49|P-value:7.95E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.85|P-value:2.48E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.87|P-value:2.36E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.99|P-value:3.13E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.72|P-value:3.88E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.18|P-value:7.36E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.93|P-value:1.77E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.76|P-value:3.38E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.25|P-value:1.02E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:7.02|P-value:1.02E-10 ID:SGTC_978|Compound:1416-0512|FD-Score:4.51|P-value:2.29E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.72|P-value:3.82E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.48|P-value:8.43E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.95|P-value:1.75E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.48|P-value:8.23E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.50|P-value:1.99E-9 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.21|P-value:7.01E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.55|P-value:6.68E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.70|P-value:4.09E-4 ID:SGTC_1616|Compound:st002734|FD-Score:7.19|P-value:3.79E-11 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.82|P-value:6.63E-6 ID:SGTC_1764|Compound:st044502|FD-Score:3.65|P-value:4.79E-4 ID:SGTC_1770|Compound:st043884|FD-Score:5.52|P-value:2.93E-7 ID:SGTC_1820|Compound:st053765|FD-Score:4.66|P-value:1.27E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.66|P-value:4.64E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.81|P-value:6.14E-6 ID:SGTC_2159|Compound:5658611|FD-Score:-4.25|P-value:5.71E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-3.45|P-value:8.52E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.42|P-value:9.87E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.91|P-value:1.87E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.61|P-value:5.11E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-4.48|P-value:2.38E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.43|P-value:9.68E-4 ID:SGTC_2702|Compound:st077768|FD-Score:6.52|P-value:1.84E-9 ID:SGTC_2781|Compound:5567276|FD-Score:3.99|P-value:1.53E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.54|P-value:1.99E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.21|P-value:7.13E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.94|P-value:1.72E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.54|P-value:6.48E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.19|P-value:7.56E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:5.71|P-value:1.19E-7 ID:SGTC_21|Compound:0849-0113|FD-Score:3.47|P-value:8.65E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.93|P-value:1.89E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.50|P-value:2.17E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:4.69|P-value:1.13E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.73|P-value:3.71E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.26|P-value:5.78E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.81|P-value:2.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.60|P-value:1.58E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-3.49|P-value:7.53E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.84|P-value:2.62E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.49|P-value:7.95E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.85|P-value:2.48E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.87|P-value:2.36E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.99|P-value:3.13E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.72|P-value:3.88E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.18|P-value:7.36E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.93|P-value:1.77E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.76|P-value:3.38E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.25|P-value:1.02E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:7.02|P-value:1.02E-10 ID:SGTC_978|Compound:1416-0512|FD-Score:4.51|P-value:2.29E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.72|P-value:3.82E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.48|P-value:8.43E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.95|P-value:1.75E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.48|P-value:8.23E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.50|P-value:1.99E-9 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.21|P-value:7.01E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.55|P-value:6.68E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.70|P-value:4.09E-4 ID:SGTC_1616|Compound:st002734|FD-Score:7.19|P-value:3.79E-11 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.82|P-value:6.63E-6 ID:SGTC_1764|Compound:st044502|FD-Score:3.65|P-value:4.79E-4 ID:SGTC_1770|Compound:st043884|FD-Score:5.52|P-value:2.93E-7 ID:SGTC_1820|Compound:st053765|FD-Score:4.66|P-value:1.27E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.66|P-value:4.64E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.81|P-value:6.14E-6 ID:SGTC_2159|Compound:5658611|FD-Score:-4.25|P-value:5.71E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-3.45|P-value:8.52E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.42|P-value:9.87E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.91|P-value:1.87E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.61|P-value:5.11E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-4.48|P-value:2.38E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.43|P-value:9.68E-4 ID:SGTC_2702|Compound:st077768|FD-Score:6.52|P-value:1.84E-9 ID:SGTC_2781|Compound:5567276|FD-Score:3.99|P-value:1.53E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.54|P-value:1.99E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.21|P-value:7.13E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.94|P-value:1.72E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.54|P-value:6.48E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.19|P-value:7.56E-5

Top fitness defect scores for YDL035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1616 st002734 7.19 56.1 µM 3.79E-11 4 3.23E-13
2 SGTC_977 1348-1378 7.02 135.0 µM 1.02E-10 3 1.07E-12
3 SGTC_2702 st077768 6.52 96.8 µM 1.84E-9 1 3.60E-11
4 SGTC_1161 k007-0610 6.50 110.0 µM 1.99E-9 ERAD & cell cycle 52 3.96E-11
5 SGTC_3 0833-0587 5.71 95.6 µM 1.19E-7 redox potentiating 9 5.63E-9
6 SGTC_1770 st043884 5.52 66.3 µM 2.93E-7 4 1.68E-8
7 SGTC_937 3122-0005 5.25 46.7 µM 1.02E-6 12 7.57E-8
8 SGTC_779 1360-0071 4.99 233.0 µM 3.13E-6 fatty acid desaturase (OLE1) 13 2.96E-7
9 SGTC_1679 4130-1276 4.82 6.7 µM 6.63E-6 Golgi 39 7.34E-7
10 SGTC_198 3454-2873 4.69 16.2 µM 1.13E-5 60S ribosome export 5 1.40E-6
11 SGTC_1820 st053765 4.66 18.6 µM 1.27E-5 RPP1 & pyrimidine depletion 3 1.62E-6
12 SGTC_453 enantio-paf c16 4.60 10.0 µM 1.58E-5 104 2.11E-6
13 SGTC_2794 7785382 4.54 27.3 µM 1.99E-5 15 2.78E-6
14 SGTC_978 1416-0512 4.51 87.4 µM 2.29E-5 redox potentiating 20 3.30E-6
15 SGTC_258 haloperidol 4.26 50.8 µM 5.78E-5 fatty acid desaturase (OLE1) 25 1.01E-5
16 SGTC_1257 0669-0121 4.21 16.0 µM 7.01E-5 20 1.27E-5
17 SGTC_2935 9038016 4.21 30.0 µM 7.13E-5 14 1.30E-5
18 SGTC_3349 9149703 4.19 23.0 µM 7.56E-5 11 1.39E-5
19 SGTC_2781 5567276 3.99 71.4 µM 1.53E-4 45 3.25E-5
20 SGTC_1103 duloxetine 3.95 36.1 µM 1.75E-4 31 3.83E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.54E-17 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.127 1.78E-13 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.123 6.99E-13 YER020W GPA2 hom Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.118 6.04E-12 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.118 8.39E-12 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.111 1.01E-10 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.106 8.80E-10 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.101 4.37E-9 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.100 5.95E-9 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.098 1.25E-8 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.095 3.33E-8 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.090 1.92E-7 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.088 3.19E-7 YOR142W LSC1 hom Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
0.086 6.94E-7 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.083 1.62E-6 YOR366W_d YOR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C