YDL037C / BSC1

Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL037C / BSC1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:7.96|P-value:1.08E-14 ID:SGTC_43|Compound:0570-0105|FD-Score:4.53|P-value:6.49E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:9.42|P-value:8.43E-20 ID:SGTC_66|Compound:0109-0187|FD-Score:-8.91|P-value:1.17E-17 ID:SGTC_213|Compound:1246-0773|FD-Score:5.07|P-value:5.45E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.42|P-value:6.18E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.22|P-value:2.36E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:4.30|P-value:1.72E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.88|P-value:9.15E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:3.48|P-value:3.95E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.50|P-value:4.65E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.82|P-value:1.48E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.04|P-value:6.64E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:-4.12|P-value:4.83E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.89|P-value:8.72E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-5.43|P-value:1.28E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:3.26|P-value:8.24E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.45|P-value:4.38E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.27|P-value:9.93E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.99|P-value:8.03E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.43|P-value:5.92E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.40|P-value:5.11E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.60|P-value:3.33E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.22|P-value:2.39E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.71|P-value:1.71E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.60|P-value:4.85E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.10|P-value:3.87E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.94|P-value:9.42E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.37|P-value:5.66E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.77|P-value:2.19E-6 ID:SGTC_1628|Compound:st004252|FD-Score:3.65|P-value:2.14E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.49|P-value:4.88E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-3.63|P-value:3.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.69|P-value:2.43E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.31|P-value:8.67E-4 ID:SGTC_2404|Compound:5161160|FD-Score:5.19|P-value:2.95E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.78|P-value:1.75E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-5.81|P-value:1.71E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.90|P-value:8.29E-26 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.81|P-value:1.83E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.48|P-value:7.88E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.73|P-value:2.71E-6 ID:SGTC_2505|Compound:galangin|FD-Score:-3.53|P-value:4.23E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.48|P-value:3.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-15.50|P-value:1.93E-49 ID:SGTC_2585|Compound:alliin|FD-Score:5.05|P-value:5.98E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-5.24|P-value:3.32E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.34|P-value:7.92E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.82|P-value:1.13E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.21|P-value:9.82E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.12|P-value:2.11E-9 ID:SGTC_2953|Compound:9074162|FD-Score:-3.64|P-value:2.90E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-4.37|P-value:1.69E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-6.84|P-value:4.03E-11 ID:SGTC_8|Compound:0354-0001|FD-Score:7.96|P-value:1.08E-14 ID:SGTC_43|Compound:0570-0105|FD-Score:4.53|P-value:6.49E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:9.42|P-value:8.43E-20 ID:SGTC_66|Compound:0109-0187|FD-Score:-8.91|P-value:1.17E-17 ID:SGTC_213|Compound:1246-0773|FD-Score:5.07|P-value:5.45E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.42|P-value:6.18E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.22|P-value:2.36E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:4.30|P-value:1.72E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.88|P-value:9.15E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:3.48|P-value:3.95E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.50|P-value:4.65E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.82|P-value:1.48E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.04|P-value:6.64E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:-4.12|P-value:4.83E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.89|P-value:8.72E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-5.43|P-value:1.28E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:3.26|P-value:8.24E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.45|P-value:4.38E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.27|P-value:9.93E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.99|P-value:8.03E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.43|P-value:5.92E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.40|P-value:5.11E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.60|P-value:3.33E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.22|P-value:2.39E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.71|P-value:1.71E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.60|P-value:4.85E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.10|P-value:3.87E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.94|P-value:9.42E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.37|P-value:5.66E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.77|P-value:2.19E-6 ID:SGTC_1628|Compound:st004252|FD-Score:3.65|P-value:2.14E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.49|P-value:4.88E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-3.63|P-value:3.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.69|P-value:2.43E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.31|P-value:8.67E-4 ID:SGTC_2404|Compound:5161160|FD-Score:5.19|P-value:2.95E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.78|P-value:1.75E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-5.81|P-value:1.71E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.90|P-value:8.29E-26 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.81|P-value:1.83E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.48|P-value:7.88E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.73|P-value:2.71E-6 ID:SGTC_2505|Compound:galangin|FD-Score:-3.53|P-value:4.23E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.48|P-value:3.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-15.50|P-value:1.93E-49 ID:SGTC_2585|Compound:alliin|FD-Score:5.05|P-value:5.98E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-5.24|P-value:3.32E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.34|P-value:7.92E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.82|P-value:1.13E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.21|P-value:9.82E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.12|P-value:2.11E-9 ID:SGTC_2953|Compound:9074162|FD-Score:-3.64|P-value:2.90E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-4.37|P-value:1.69E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-6.84|P-value:4.03E-11

Top fitness defect scores for YDL037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2408 sulbentine 10.90 18.4 µM 8.29E-26 5 6.28E-28
2 SGTC_58 0957-0393 9.42 9.0 µM 8.43E-20 cell wall 92 2.26E-21
3 SGTC_8 0354-0001 7.96 70.0 µM 1.08E-14 10 8.40E-16
4 SGTC_2688 kanamycin b 6.12 96.7 µM 2.11E-9 calcium & mitochondrial duress 152 4.82E-10
5 SGTC_2404 5161160 5.19 200.0 µM 2.95E-7 6 1.03E-7
6 SGTC_213 1246-0773 5.07 967.0 nM 5.45E-7 6 2.01E-7
7 SGTC_2585 alliin 5.05 100.0 µM 5.98E-7 11 2.23E-7
8 SGTC_999 4022-0066 4.99 22.7 µM 8.03E-7 Golgi 19 3.06E-7
9 SGTC_2417 cerulenin 4.81 830.0 nM 1.83E-6 13 7.48E-7
10 SGTC_1448 4255-0083 4.77 152.0 µM 2.19E-6 ERG2 7 9.11E-7
11 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.73 3.7 µM 2.71E-6 39 1.15E-6
12 SGTC_1241 0364-0022 4.60 50.8 µM 4.85E-6 ERG2 20 2.16E-6
13 SGTC_43 0570-0105 4.53 72.5 µM 6.49E-6 ERG2 68 2.96E-6
14 SGTC_2419 paclitaxel 4.48 166.5 µM 7.88E-6 24 3.65E-6
15 SGTC_543 3844-1095 4.30 191.0 µM 1.72E-5 ERG2 44 8.51E-6
16 SGTC_457 grayanotoxin iii 4.22 135.0 µM 2.36E-5 53 1.20E-5
17 SGTC_1198 1612-1005 4.22 86.7 µM 2.39E-5 7 1.21E-5
18 SGTC_1250 0485-0349 4.10 40.2 µM 3.87E-5 31 2.05E-5
19 SGTC_849 0386-0493 3.89 241.0 µM 8.72E-5 21 4.93E-5
20 SGTC_560 2332-1943 3.88 155.0 µM 9.15E-5 11 5.19E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 6.45E-51 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.224 1.58E-39 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.203 1.27E-32 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.197 8.37E-31 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.196 2.85E-30 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.186 1.29E-27 YDL052C SLC1 hom 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.176 8.02E-25 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.173 5.77E-24 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.173 6.10E-24 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.170 2.99E-23 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.166 2.98E-22 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.159 1.67E-20 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.154 2.75E-19 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.150 2.54E-18 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.148 8.51E-18 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1