YDL040C / NAT1

Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL040C / NAT1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.41|P-value:1.12E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:4.23|P-value:2.36E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.91|P-value:2.60E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:3.37|P-value:5.60E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.98|P-value:6.37E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.38|P-value:2.49E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:7.76|P-value:6.87E-14 ID:SGTC_87|Compound:0100-0052|FD-Score:3.39|P-value:5.23E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.89|P-value:1.61E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.52|P-value:3.38E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.35|P-value:1.47E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.75|P-value:1.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.16|P-value:3.85E-7 ID:SGTC_213|Compound:1246-0773|FD-Score:4.12|P-value:3.72E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.51|P-value:7.20E-6 ID:SGTC_397|Compound:arbidol|FD-Score:-3.60|P-value:4.42E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.34|P-value:6.31E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.06|P-value:6.04E-7 ID:SGTC_424|Compound:splitomicin|FD-Score:3.40|P-value:5.02E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.30|P-value:3.40E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.56|P-value:5.12E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.78|P-value:2.26E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.20|P-value:9.85E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.77|P-value:1.39E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.57|P-value:2.81E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.91|P-value:8.34E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.38|P-value:5.43E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.46|P-value:4.16E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.82|P-value:1.17E-4 ID:SGTC_918|Compound:glabranin|FD-Score:9.71|P-value:1.23E-20 ID:SGTC_958|Compound:1222-0007|FD-Score:-4.16|P-value:5.76E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.69|P-value:3.31E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.09|P-value:7.77E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.52|P-value:6.93E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.49|P-value:7.85E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.60|P-value:2.55E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.24|P-value:8.55E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.52|P-value:7.16E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.42|P-value:1.08E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-4.70|P-value:6.52E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.86|P-value:2.77E-11 ID:SGTC_1694|Compound:st024011|FD-Score:5.20|P-value:3.16E-7 ID:SGTC_1710|Compound:st031758|FD-Score:3.39|P-value:5.29E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.50|P-value:1.58E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.78|P-value:2.35E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.60|P-value:2.56E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.74|P-value:1.53E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.61|P-value:1.38E-10 ID:SGTC_1974|Compound:st069448|FD-Score:4.21|P-value:2.59E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-6.21|P-value:3.62E-9 ID:SGTC_2092|Compound:5303694|FD-Score:3.46|P-value:4.10E-4 ID:SGTC_2139|Compound:5578692|FD-Score:5.29|P-value:2.04E-7 ID:SGTC_2146|Compound:5545642|FD-Score:4.35|P-value:1.43E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.89|P-value:1.63E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.41|P-value:4.94E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.44|P-value:4.45E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.59|P-value:4.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.82|P-value:1.85E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.09|P-value:5.36E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.07|P-value:3.22E-9 ID:SGTC_2701|Compound:st077767|FD-Score:4.42|P-value:1.10E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.50|P-value:3.66E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-5.08|P-value:1.16E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-3.77|P-value:2.48E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.87|P-value:9.45E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.88|P-value:1.69E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:5.41|P-value:1.12E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:4.23|P-value:2.36E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.91|P-value:2.60E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:3.37|P-value:5.60E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.98|P-value:6.37E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.38|P-value:2.49E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:7.76|P-value:6.87E-14 ID:SGTC_87|Compound:0100-0052|FD-Score:3.39|P-value:5.23E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.89|P-value:1.61E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.52|P-value:3.38E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.35|P-value:1.47E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.75|P-value:1.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.16|P-value:3.85E-7 ID:SGTC_213|Compound:1246-0773|FD-Score:4.12|P-value:3.72E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.51|P-value:7.20E-6 ID:SGTC_397|Compound:arbidol|FD-Score:-3.60|P-value:4.42E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.34|P-value:6.31E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.06|P-value:6.04E-7 ID:SGTC_424|Compound:splitomicin|FD-Score:3.40|P-value:5.02E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.30|P-value:3.40E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.56|P-value:5.12E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.78|P-value:2.26E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.20|P-value:9.85E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.77|P-value:1.39E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.57|P-value:2.81E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.91|P-value:8.34E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.38|P-value:5.43E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.46|P-value:4.16E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.82|P-value:1.17E-4 ID:SGTC_918|Compound:glabranin|FD-Score:9.71|P-value:1.23E-20 ID:SGTC_958|Compound:1222-0007|FD-Score:-4.16|P-value:5.76E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.69|P-value:3.31E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.09|P-value:7.77E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.52|P-value:6.93E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.49|P-value:7.85E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.60|P-value:2.55E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.24|P-value:8.55E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.52|P-value:7.16E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.42|P-value:1.08E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-4.70|P-value:6.52E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.86|P-value:2.77E-11 ID:SGTC_1694|Compound:st024011|FD-Score:5.20|P-value:3.16E-7 ID:SGTC_1710|Compound:st031758|FD-Score:3.39|P-value:5.29E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.50|P-value:1.58E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.78|P-value:2.35E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.60|P-value:2.56E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.74|P-value:1.53E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.61|P-value:1.38E-10 ID:SGTC_1974|Compound:st069448|FD-Score:4.21|P-value:2.59E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-6.21|P-value:3.62E-9 ID:SGTC_2092|Compound:5303694|FD-Score:3.46|P-value:4.10E-4 ID:SGTC_2139|Compound:5578692|FD-Score:5.29|P-value:2.04E-7 ID:SGTC_2146|Compound:5545642|FD-Score:4.35|P-value:1.43E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.89|P-value:1.63E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.41|P-value:4.94E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.44|P-value:4.45E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.59|P-value:4.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.82|P-value:1.85E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.09|P-value:5.36E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.07|P-value:3.22E-9 ID:SGTC_2701|Compound:st077767|FD-Score:4.42|P-value:1.10E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.50|P-value:3.66E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-5.08|P-value:1.16E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-3.77|P-value:2.48E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.87|P-value:9.45E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.88|P-value:1.69E-4

Top fitness defect scores for YDL040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_918 glabranin 9.71 770.7 nM 1.23E-20 1 1.40E-22
2 SGTC_46 0329-0187a 7.76 2.2 µM 6.87E-14 17 4.35E-15
3 SGTC_1635 st007035 6.86 42.4 µM 2.77E-11 121 3.35E-12
4 SGTC_1877 wortmannin 6.61 25.0 µM 1.38E-10 39 1.98E-11
5 SGTC_2679 rapamycin 6.07 1.0 nM 3.22E-9 75 6.46E-10
6 SGTC_7 0192-1582 5.41 4.2 µM 1.12E-7 30 3.23E-8
7 SGTC_2139 5578692 5.29 56.5 µM 2.04E-7 superoxide 6 6.28E-8
8 SGTC_1694 st024011 5.20 44.9 µM 3.16E-7 ERG2 15 1.02E-7
9 SGTC_178 4092-0806 5.16 87.5 µM 3.85E-7 ergosterol depletion effects on membrane 53 1.26E-7
10 SGTC_2651 1327-0036 5.09 5.0 µM 5.36E-7 105 1.82E-7
11 SGTC_422 cantharidin 5.06 155.0 µM 6.04E-7 cell wall signaling 33 2.08E-7
12 SGTC_2619 obliquin 4.82 87.9 µM 1.85E-6 cell wall 102 7.10E-7
13 SGTC_454 lyso-paf C-16 4.78 6.7 µM 2.26E-6 7 8.88E-7
14 SGTC_1019 4262-0212 4.69 3.4 µM 3.31E-6 ergosterol depletion effects on membrane 36 1.35E-6
15 SGTC_1099 5-nonyloxytryptamine 4.52 2.9 µM 6.93E-6 10 3.04E-6
16 SGTC_1425 4048-4433 4.52 7.3 µM 7.16E-6 copper-dependent oxidative stress 26 3.15E-6
17 SGTC_241 5hr heat shock (37°C) + cantharidin 4.51 155.4 µM 7.20E-6 cell wall signaling 56 3.17E-6
18 SGTC_1180 1193-0155 4.49 285.0 µM 7.85E-6 6 3.49E-6
19 SGTC_1511 0906-3109 4.42 28.5 µM 1.08E-5 excess fatty acid 30 4.95E-6
20 SGTC_2701 st077767 4.42 14.7 µM 1.10E-5 28 5.05E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 3.56E-44 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.225 1.06E-39 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.216 9.07E-37 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.211 3.30E-35 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.210 1.15E-34 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.188 3.69E-28 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.186 1.24E-27 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.177 5.52E-25 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.175 1.82E-24 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.167 2.26E-22 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.156 9.67E-20 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.155 1.40E-19 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.152 8.45E-19 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.152 9.58E-19 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.152 1.00E-18 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M