YDL041W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL041W / YDL041W

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.99|P-value:2.38E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:4.17|P-value:1.47E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.69|P-value:6.79E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.05|P-value:2.19E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.08|P-value:1.97E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:12.60|P-value:2.86E-28 ID:SGTC_149|Compound:3970-0822|FD-Score:4.42|P-value:6.18E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:4.38|P-value:6.96E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.86|P-value:3.61E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.59|P-value:9.04E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.77|P-value:4.66E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.03|P-value:6.61E-8 ID:SGTC_351|Compound:caspofungin|FD-Score:3.63|P-value:8.18E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.89|P-value:3.23E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.30|P-value:8.34E-11 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.83|P-value:1.96E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.31|P-value:2.01E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:3.78|P-value:5.19E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.07|P-value:2.05E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:7.78|P-value:6.39E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:5.71|P-value:3.42E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:6.16|P-value:4.20E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:5.11|P-value:4.46E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:4.97|P-value:7.76E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:5.00|P-value:6.76E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.64|P-value:7.95E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.72|P-value:2.07E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.91|P-value:8.89E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.29|P-value:9.51E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.69|P-value:2.32E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.96|P-value:2.91E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:6.34|P-value:1.76E-8 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.79|P-value:1.58E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.29|P-value:9.52E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.67|P-value:7.26E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.62|P-value:7.50E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.92|P-value:3.36E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.61|P-value:3.08E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.74|P-value:5.87E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-4.61|P-value:2.64E-5 ID:SGTC_1547|Compound:harmine|FD-Score:10.10|P-value:5.21E-19 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.97|P-value:2.86E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.56|P-value:3.73E-5 ID:SGTC_1628|Compound:st004252|FD-Score:4.05|P-value:2.20E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.95|P-value:2.99E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.52|P-value:4.31E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.77|P-value:4.75E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.05|P-value:2.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.75|P-value:2.07E-9 ID:SGTC_1752|Compound:st044819|FD-Score:3.80|P-value:4.85E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.75|P-value:5.66E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.72|P-value:6.27E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.40|P-value:6.63E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.40|P-value:9.03E-20 ID:SGTC_1873|Compound:rapamycin|FD-Score:8.18|P-value:5.38E-13 ID:SGTC_2077|Compound:5212015|FD-Score:3.91|P-value:3.40E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.85|P-value:4.11E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.79|P-value:1.59E-5 ID:SGTC_2307|Compound:7538926|FD-Score:9.67|P-value:1.89E-17 ID:SGTC_2444|Compound:5485484|FD-Score:4.48|P-value:4.89E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.95|P-value:2.70E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.64|P-value:4.72E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.59|P-value:5.77E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.83|P-value:1.40E-9 ID:SGTC_2710|Compound:st078562|FD-Score:4.40|P-value:6.56E-5 ID:SGTC_2716|Compound:st080858|FD-Score:-3.62|P-value:7.39E-4 ID:SGTC_2744|Compound:captopril|FD-Score:-3.86|P-value:3.61E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.81|P-value:2.16E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-3.82|P-value:3.99E-4 ID:SGTC_2824|Compound:7998404|FD-Score:6.96|P-value:6.87E-10 ID:SGTC_2883|Compound:9059145|FD-Score:4.51|P-value:4.50E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.88|P-value:3.80E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.54|P-value:3.91E-5 ID:SGTC_3221|Compound:9128209|FD-Score:4.05|P-value:2.19E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.99|P-value:2.38E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:4.17|P-value:1.47E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.69|P-value:6.79E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.05|P-value:2.19E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.08|P-value:1.97E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:12.60|P-value:2.86E-28 ID:SGTC_149|Compound:3970-0822|FD-Score:4.42|P-value:6.18E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:4.38|P-value:6.96E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.86|P-value:3.61E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.59|P-value:9.04E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.77|P-value:4.66E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.03|P-value:6.61E-8 ID:SGTC_351|Compound:caspofungin|FD-Score:3.63|P-value:8.18E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.89|P-value:3.23E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.30|P-value:8.34E-11 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.83|P-value:1.96E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.31|P-value:2.01E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:3.78|P-value:5.19E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.07|P-value:2.05E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:7.78|P-value:6.39E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:5.71|P-value:3.42E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:6.16|P-value:4.20E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:5.11|P-value:4.46E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:4.97|P-value:7.76E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:5.00|P-value:6.76E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.64|P-value:7.95E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.72|P-value:2.07E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.91|P-value:8.89E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.29|P-value:9.51E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.69|P-value:2.32E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.96|P-value:2.91E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:6.34|P-value:1.76E-8 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.79|P-value:1.58E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.29|P-value:9.52E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.67|P-value:7.26E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.62|P-value:7.50E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.92|P-value:3.36E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.61|P-value:3.08E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.74|P-value:5.87E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-4.61|P-value:2.64E-5 ID:SGTC_1547|Compound:harmine|FD-Score:10.10|P-value:5.21E-19 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.97|P-value:2.86E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.56|P-value:3.73E-5 ID:SGTC_1628|Compound:st004252|FD-Score:4.05|P-value:2.20E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.95|P-value:2.99E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.52|P-value:4.31E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.77|P-value:4.75E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.05|P-value:2.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.75|P-value:2.07E-9 ID:SGTC_1752|Compound:st044819|FD-Score:3.80|P-value:4.85E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.75|P-value:5.66E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.72|P-value:6.27E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.40|P-value:6.63E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.40|P-value:9.03E-20 ID:SGTC_1873|Compound:rapamycin|FD-Score:8.18|P-value:5.38E-13 ID:SGTC_2077|Compound:5212015|FD-Score:3.91|P-value:3.40E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.85|P-value:4.11E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.79|P-value:1.59E-5 ID:SGTC_2307|Compound:7538926|FD-Score:9.67|P-value:1.89E-17 ID:SGTC_2444|Compound:5485484|FD-Score:4.48|P-value:4.89E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.95|P-value:2.70E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.64|P-value:4.72E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.59|P-value:5.77E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.83|P-value:1.40E-9 ID:SGTC_2710|Compound:st078562|FD-Score:4.40|P-value:6.56E-5 ID:SGTC_2716|Compound:st080858|FD-Score:-3.62|P-value:7.39E-4 ID:SGTC_2744|Compound:captopril|FD-Score:-3.86|P-value:3.61E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.81|P-value:2.16E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-3.82|P-value:3.99E-4 ID:SGTC_2824|Compound:7998404|FD-Score:6.96|P-value:6.87E-10 ID:SGTC_2883|Compound:9059145|FD-Score:4.51|P-value:4.50E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.88|P-value:3.80E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.54|P-value:3.91E-5 ID:SGTC_3221|Compound:9128209|FD-Score:4.05|P-value:2.19E-4

Top fitness defect scores for YDL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_146 3448-8650 12.60 53.1 µM 2.86E-28 NEO1-PIK1 11 1.34E-36
2 SGTC_1844 rapamycin 10.40 4.0 nM 9.03E-20 36 1.90E-25
3 SGTC_1547 harmine 10.10 94.2 µM 5.21E-19 ergosterol biosynthesis 5 1.89E-24
4 SGTC_2307 7538926 9.67 6.3 µM 1.89E-17 2 2.10E-22
5 SGTC_1873 rapamycin 8.18 2.0 nM 5.38E-13 12 1.45E-16
6 SGTC_524 r073-0010 7.78 27.8 µM 6.39E-12 10 3.71E-15
7 SGTC_2824 7998404 6.96 52.0 µM 6.87E-10 2 1.69E-12
8 SGTC_1083 didemethylchlorpromazine sulfoxide 6.91 707.4 nM 8.89E-10 redox potentiating 17 2.37E-12
9 SGTC_2679 rapamycin 6.83 1.0 nM 1.40E-9 63 4.32E-12
10 SGTC_1750 st081859 6.75 2.4 µM 2.07E-9 endomembrane recycling 93 7.19E-12
11 SGTC_1286 0929-0070 6.34 131.0 µM 1.76E-8 3 1.18E-10
12 SGTC_488 nitrendipine 6.31 139.0 µM 2.01E-8 14 1.40E-10
13 SGTC_660 4031-1742 6.16 102.0 µM 4.20E-8 redox potentiating 10 3.68E-10
14 SGTC_481 bay k-8644 5.83 50.0 µM 1.96E-7 8 2.76E-9
15 SGTC_2779 methotrexate 5.81 400.0 µM 2.16E-7 13 3.13E-9
16 SGTC_528 3492-0019 5.71 172.0 µM 3.42E-7 calcium & mitochondrial duress 130 5.71E-9
17 SGTC_2615 purpurogallin-4-carboxylic acid 5.64 100.0 µM 4.72E-7 redox potentiating 28 8.68E-9
18 SGTC_2666 tannic acid 5.59 100.0 µM 5.77E-7 iron homeostasis 12 1.13E-8
19 SGTC_733 4069-0007 5.11 56.1 µM 4.46E-6 ERAD & cell cycle 53 1.63E-7
20 SGTC_805 3852-0218 5.00 479.0 µM 6.76E-6 ERAD & cell cycle 36 2.80E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 1.12E-76 YAL021C CCR4 hom Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
0.235 1.79E-43 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.233 1.53E-42 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.233 2.15E-42 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.229 4.77E-41 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.215 2.91E-36 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.212 1.99E-35 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.210 1.39E-34 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.207 5.67E-34 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.207 5.73E-34 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.206 2.22E-33 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.206 2.37E-33 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.204 1.00E-32 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.202 2.78E-32 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.193 1.62E-29 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome