YDL043C / PRP11

Subunit of the SF3a splicing factor complex, required for spliceosome assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL043C / PRP11

Click on Significant Values for Screen Details ID:SGTC_880|Compound:0833-0487|FD-Score:3.57|P-value:2.12E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.46|P-value:3.25E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.31|P-value:5.18E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.66|P-value:2.09E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.38|P-value:3.95E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.15|P-value:8.75E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.83|P-value:7.39E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.17|P-value:8.83E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.32|P-value:5.30E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.17|P-value:8.78E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.83|P-value:7.21E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-4.34|P-value:8.59E-6 ID:SGTC_1846|Compound:st056244|FD-Score:-3.25|P-value:6.21E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.34|P-value:4.94E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.91|P-value:5.85E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.73|P-value:1.15E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.30|P-value:5.37E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.38|P-value:4.31E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_3096|Compound:9117468|FD-Score:-3.16|P-value:8.46E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.57|P-value:2.12E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.46|P-value:3.25E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.31|P-value:5.18E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.66|P-value:2.09E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.38|P-value:3.95E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.15|P-value:8.75E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.83|P-value:7.39E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.17|P-value:8.83E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.32|P-value:5.30E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.17|P-value:8.78E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.83|P-value:7.21E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-4.34|P-value:8.59E-6 ID:SGTC_1846|Compound:st056244|FD-Score:-3.25|P-value:6.21E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.34|P-value:4.94E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.91|P-value:5.85E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.73|P-value:1.15E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.30|P-value:5.37E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.38|P-value:4.31E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_3096|Compound:9117468|FD-Score:-3.16|P-value:8.46E-4

Top fitness defect scores for YDL043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1065 prochlorperazine maleate 4.66 2.5 µM 2.09E-6 4 1.56E-6 0.39
2 SGTC_3077 9117319 3.96 49.5 µM 4.72E-5 7 3.78E-5 0.02
3 SGTC_2450 5739737 3.91 12.9 µM 5.85E-5 4 4.71E-5 0.11
4 SGTC_2607 solasodine 3.73 47.4 µM 1.15E-4 15 9.39E-5 0.00
5 SGTC_1127 asiatic acid 3.63 681.4 nM 1.72E-4 8 1.42E-4 0.10
6 SGTC_880 0833-0487 3.57 87.2 µM 2.12E-4 mitochondrial processes 2 1.76E-4 0.14
7 SGTC_1046 2001-0062 3.46 216.0 µM 3.25E-4 4 2.73E-4 0.06
8 SGTC_2813 7971799 3.38 71.4 µM 4.31E-4 16 3.64E-4 0.07
9 SGTC_2062 5245942 3.34 200.0 µM 4.94E-4 4 4.19E-4 0.11
10 SGTC_1297 1068-0111 3.32 14.1 µM 5.30E-4 9 4.50E-4 0.07
11 SGTC_1684 st024538 3.17 14.6 µM 8.78E-4 6 7.53E-4 0.12
12 SGTC_1225 1216-0074 3.17 20.6 µM 8.83E-4 5 7.58E-4 0.05
13 SGTC_1819 st053448 3.08 58.6 µM 0.00121 amide catabolism 9 0.00105 0.05
14 SGTC_1857 st056007 3.04 79.3 µM 0.00134 7 0.00116 0.25
15 SGTC_2800 7887935 3.04 81.8 µM 0.00135 RPP1 & pyrimidine depletion 20 0.00117 0.01
16 SGTC_2795 7780010 3.02 54.5 µM 0.00147 17 0.00128 0.22
17 SGTC_2694 st077685 2.97 81.9 µM 0.00170 endomembrane recycling 13 0.00148 0.04
18 SGTC_3092 9117248 2.96 49.5 µM 0.00178 cell wall signaling 5 0.00155 0.23
19 SGTC_3005 9076496 2.95 71.4 µM 0.00183 7 0.00159 0.05
20 SGTC_2793 7325131 2.93 81.8 µM 0.00196 18 0.00171 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.85E-13 YDR465C RMT2 hom Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress
0.115 2.14E-11 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.110 1.61E-10 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.109 2.81E-10 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.65E-9 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.099 9.21E-9 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.097 1.90E-8 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.096 2.81E-8 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.090 1.94E-7 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.084 1.02E-6 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.084 1.05E-6 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.084 1.10E-6 YPR027C_p YPR027C_p hom Putative protein of unknown function
0.083 1.64E-6 YHL046C PAU13 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock
0.081 2.80E-6 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.079 4.39E-6 YBR060C ORC2 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p