YDL044C / MTF2

Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL044C / MTF2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.54|P-value:8.85E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:4.27|P-value:2.70E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.79|P-value:1.73E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.38|P-value:6.98E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.82|P-value:6.19E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:9.03|P-value:5.79E-18 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.35|P-value:7.88E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.11|P-value:8.00E-12 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.62|P-value:2.77E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.35|P-value:1.65E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:5.36|P-value:1.96E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.85|P-value:1.18E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.90|P-value:1.80E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:3.37|P-value:7.33E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.46|P-value:5.47E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.37|P-value:6.33E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.56|P-value:3.85E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.65|P-value:2.77E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.30|P-value:2.67E-7 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.07|P-value:5.99E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.38|P-value:7.07E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.36|P-value:1.90E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-4.79|P-value:2.49E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.34|P-value:2.21E-7 ID:SGTC_1236|Compound:0330-0013|FD-Score:-4.64|P-value:4.81E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.69|P-value:3.68E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.81|P-value:1.61E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.61|P-value:3.25E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.57|P-value:3.74E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.54|P-value:4.11E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.39|P-value:5.99E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.30|P-value:2.34E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-4.19|P-value:3.22E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.84|P-value:1.21E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.64|P-value:2.94E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.97|P-value:7.66E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.79|P-value:1.72E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.73|P-value:1.82E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.31|P-value:8.86E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.45|P-value:5.59E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.97|P-value:8.75E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.28|P-value:2.62E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.96|P-value:9.02E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.49|P-value:4.97E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.25|P-value:3.38E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.38|P-value:6.31E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.29|P-value:9.51E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.33|P-value:8.31E-10 ID:SGTC_2966|Compound:9084041|FD-Score:4.19|P-value:3.78E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.51|P-value:4.52E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.41|P-value:1.49E-5 ID:SGTC_3130|Compound:9127414|FD-Score:3.38|P-value:7.13E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.52|P-value:4.37E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.35|P-value:7.87E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.30|P-value:9.06E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.33|P-value:1.80E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.54|P-value:8.85E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:4.27|P-value:2.70E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.79|P-value:1.73E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.38|P-value:6.98E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.82|P-value:6.19E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:9.03|P-value:5.79E-18 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.35|P-value:7.88E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.11|P-value:8.00E-12 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.62|P-value:2.77E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.35|P-value:1.65E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:5.36|P-value:1.96E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.85|P-value:1.18E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.90|P-value:1.80E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:3.37|P-value:7.33E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.46|P-value:5.47E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.37|P-value:6.33E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.56|P-value:3.85E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.65|P-value:2.77E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.30|P-value:2.67E-7 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.07|P-value:5.99E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.38|P-value:7.07E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.36|P-value:1.90E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-4.79|P-value:2.49E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.34|P-value:2.21E-7 ID:SGTC_1236|Compound:0330-0013|FD-Score:-4.64|P-value:4.81E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.69|P-value:3.68E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.81|P-value:1.61E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.61|P-value:3.25E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.57|P-value:3.74E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.54|P-value:4.11E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.39|P-value:5.99E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.30|P-value:2.34E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-4.19|P-value:3.22E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.84|P-value:1.21E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.64|P-value:2.94E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.97|P-value:7.66E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.79|P-value:1.72E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.73|P-value:1.82E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.31|P-value:8.86E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.45|P-value:5.59E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.97|P-value:8.75E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.28|P-value:2.62E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.96|P-value:9.02E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.49|P-value:4.97E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.25|P-value:3.38E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.38|P-value:6.31E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.29|P-value:9.51E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.33|P-value:8.31E-10 ID:SGTC_2966|Compound:9084041|FD-Score:4.19|P-value:3.78E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.51|P-value:4.52E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.41|P-value:1.49E-5 ID:SGTC_3130|Compound:9127414|FD-Score:3.38|P-value:7.13E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.52|P-value:4.37E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.35|P-value:7.87E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.30|P-value:9.06E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.33|P-value:1.80E-5

Top fitness defect scores for YDL044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.03 5.3 µM 5.79E-18 219 8.79E-20
2 SGTC_173 1273-0061 7.82 2.7 µM 6.19E-14 mitochondrial stress 71 2.59E-15
3 SGTC_310 1273-0058 7.11 1.1 µM 8.00E-12 mitochondrial stress 115 5.68E-13
4 SGTC_1238 0333-0287 5.69 48.8 µM 3.68E-8 Golgi 8 6.53E-9
5 SGTC_520 3584-0023 5.36 682.0 µM 1.96E-7 6 4.18E-8
6 SGTC_1231 0242-0792 5.34 125.0 µM 2.21E-7 5 4.78E-8
7 SGTC_1178 0988-0033 5.30 191.0 µM 2.67E-7 11 5.87E-8
8 SGTC_2526 patulin 5.25 37.6 µM 3.38E-7 41 7.62E-8
9 SGTC_578 3460-0051 4.90 92.0 µM 1.80E-6 3 4.87E-7
10 SGTC_10 0279-0212 4.54 42.6 µM 8.85E-6 TRP & mitochondrial translation 91 2.84E-6
11 SGTC_2998 9066762 4.41 71.4 µM 1.49E-5 RPP1 & pyrimidine depletion 17 5.07E-6
12 SGTC_1224 0823-0416 4.36 294.0 µM 1.90E-5 2 6.65E-6
13 SGTC_1575 cyproterone acetate 4.30 48.0 µM 2.34E-5 13 8.37E-6
14 SGTC_2232 chlorophetanol 4.28 41.5 µM 2.62E-5 TRP & mitochondrial translation 109 9.45E-6
15 SGTC_19 0279-0214 4.27 38.4 µM 2.70E-5 TRP & mitochondrial translation 34 9.78E-6
16 SGTC_2966 9084041 4.19 48.0 µM 3.78E-5 27 1.42E-5
17 SGTC_1183 1254-0324 4.07 198.0 µM 5.99E-5 19 2.36E-5
18 SGTC_2203 7227154 3.97 166.4 µM 8.75E-5 11 3.60E-5
19 SGTC_2420 aureobasidin a 3.96 50.0 nM 9.02E-5 46 3.72E-5
20 SGTC_1912 st060209 3.93 90.8 µM 1.01E-4 36 4.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.388 1.65E-120 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.368 1.90E-108 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.366 1.11E-106 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.362 9.60E-105 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.360 1.59E-103 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.359 1.17E-102 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.354 6.47E-100 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.349 1.55E-96 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.348 5.64E-96 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.348 6.53E-96 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.344 6.39E-94 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.344 1.21E-93 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.342 1.65E-92 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.341 7.28E-92 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.337 1.08E-89 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress