YDL047W / SIT4

Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL047W / SIT4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:-3.23|P-value:5.75E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.91|P-value:4.22E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.11|P-value:9.51E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.95|P-value:3.94E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.92|P-value:4.49E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.11|P-value:2.03E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.11|P-value:9.65E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.16|P-value:8.05E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.13|P-value:8.80E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.47|P-value:2.67E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:5.52|P-value:1.64E-8 ID:SGTC_644|Compound:1498-1197|FD-Score:3.50|P-value:2.40E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.70|P-value:9.68E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.48|P-value:2.30E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.64|P-value:1.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:5.23|P-value:8.41E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.13|P-value:8.78E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.39|P-value:3.49E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.49|P-value:2.45E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.38|P-value:3.70E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.01|P-value:3.12E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.92|P-value:4.28E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.89|P-value:5.12E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.98|P-value:3.41E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:5.56|P-value:1.36E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.77|P-value:8.10E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.39|P-value:3.52E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.55|P-value:2.68E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.78|P-value:8.90E-7 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.90|P-value:4.94E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:4.36|P-value:6.60E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.75|P-value:9.11E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.17|P-value:7.86E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.99|P-value:3.35E-5 ID:SGTC_1703|Compound:st026983|FD-Score:4.54|P-value:2.80E-6 ID:SGTC_1754|Compound:st042065|FD-Score:4.41|P-value:5.20E-6 ID:SGTC_1758|Compound:st042942|FD-Score:-3.44|P-value:2.69E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.15|P-value:1.69E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.85|P-value:5.91E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.14|P-value:8.62E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.76|P-value:8.48E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.19|P-value:7.10E-4 ID:SGTC_1988|Compound:st071872|FD-Score:5.53|P-value:1.61E-8 ID:SGTC_2312|Compound:7706453|FD-Score:-4.18|P-value:1.31E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.88|P-value:4.84E-5 ID:SGTC_2393|Compound:9031399|FD-Score:-3.13|P-value:8.15E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.45|P-value:2.89E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.22|P-value:6.60E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.92|P-value:4.45E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.26|P-value:5.23E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.19|P-value:1.39E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:6.57|P-value:2.51E-11 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.59|P-value:1.50E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.27|P-value:5.36E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.82|P-value:6.64E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.33|P-value:4.38E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.59|P-value:1.69E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.39|P-value:5.68E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.13|P-value:8.97E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.18|P-value:6.94E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.57|P-value:1.83E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.33|P-value:4.46E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.19|P-value:7.28E-4 ID:SGTC_3265|Compound:9137266|FD-Score:5.28|P-value:6.31E-8 ID:SGTC_3280|Compound:9140961|FD-Score:3.54|P-value:2.00E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.23|P-value:5.75E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.91|P-value:4.22E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.11|P-value:9.51E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.95|P-value:3.94E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.92|P-value:4.49E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.11|P-value:2.03E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.11|P-value:9.65E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.16|P-value:8.05E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.13|P-value:8.80E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.47|P-value:2.67E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:5.52|P-value:1.64E-8 ID:SGTC_644|Compound:1498-1197|FD-Score:3.50|P-value:2.40E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.70|P-value:9.68E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.48|P-value:2.30E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.64|P-value:1.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:5.23|P-value:8.41E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.13|P-value:8.78E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.39|P-value:3.49E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.49|P-value:2.45E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.38|P-value:3.70E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.01|P-value:3.12E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.92|P-value:4.28E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.89|P-value:5.12E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.98|P-value:3.41E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:5.56|P-value:1.36E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.77|P-value:8.10E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.39|P-value:3.52E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.55|P-value:2.68E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.78|P-value:8.90E-7 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.90|P-value:4.94E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:4.36|P-value:6.60E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.75|P-value:9.11E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.17|P-value:7.86E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.99|P-value:3.35E-5 ID:SGTC_1703|Compound:st026983|FD-Score:4.54|P-value:2.80E-6 ID:SGTC_1754|Compound:st042065|FD-Score:4.41|P-value:5.20E-6 ID:SGTC_1758|Compound:st042942|FD-Score:-3.44|P-value:2.69E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.15|P-value:1.69E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.85|P-value:5.91E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.14|P-value:8.62E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.76|P-value:8.48E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.19|P-value:7.10E-4 ID:SGTC_1988|Compound:st071872|FD-Score:5.53|P-value:1.61E-8 ID:SGTC_2312|Compound:7706453|FD-Score:-4.18|P-value:1.31E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.88|P-value:4.84E-5 ID:SGTC_2393|Compound:9031399|FD-Score:-3.13|P-value:8.15E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.45|P-value:2.89E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.22|P-value:6.60E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.92|P-value:4.45E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.26|P-value:5.23E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.19|P-value:1.39E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:6.57|P-value:2.51E-11 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.59|P-value:1.50E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.27|P-value:5.36E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.82|P-value:6.64E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.33|P-value:4.38E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.59|P-value:1.69E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.39|P-value:5.68E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.13|P-value:8.97E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.18|P-value:6.94E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.57|P-value:1.83E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.33|P-value:4.46E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.19|P-value:7.28E-4 ID:SGTC_3265|Compound:9137266|FD-Score:5.28|P-value:6.31E-8 ID:SGTC_3280|Compound:9140961|FD-Score:3.54|P-value:2.00E-4

Top fitness defect scores for YDL047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2614 arthonioic acid 6.57 13.4 µM 2.51E-11 2 2.59E-11
2 SGTC_1358 1509-0022 5.56 2.5 µM 1.36E-8 3 1.37E-8
3 SGTC_1988 st071872 5.53 53.4 µM 1.61E-8 2 1.63E-8
4 SGTC_641 4092-0595 5.52 30.0 µM 1.64E-8 4 1.66E-8
5 SGTC_3265 9137266 5.28 49.5 µM 6.31E-8 2 6.35E-8
6 SGTC_974 1326-0144 5.23 138.0 µM 8.41E-8 ERG2 19 8.46E-8
7 SGTC_1176 0848-0131 4.92 83.3 µM 4.28E-7 Golgi 9 4.28E-7
8 SGTC_1452 4194-0072 4.78 190.0 µM 8.90E-7 4 8.90E-7
9 SGTC_1445 4239-0156 4.55 97.7 µM 2.68E-6 17 2.67E-6
10 SGTC_1703 st026983 4.54 48.3 µM 2.80E-6 4 2.79E-6
11 SGTC_1754 st042065 4.41 16.1 µM 5.20E-6 NEO1-PIK1 155 5.18E-6
12 SGTC_2952 9073731 4.39 13.8 µM 5.68E-6 tubulin folding & SWR complex 26 5.65E-6
13 SGTC_1462 k081-0014 4.36 26.5 µM 6.60E-6 6 6.56E-6
14 SGTC_2603 homopterocarpin 4.19 100.0 µM 1.39E-5 28 1.38E-5
15 SGTC_1759 st043059 4.15 70.0 µM 1.69E-5 amide catabolism 23 1.68E-5
16 SGTC_831 k061-1017 4.14 217.0 µM 1.78E-5 translation 55 1.76E-5
17 SGTC_221 trifluoperazine 4.11 10.3 µM 2.03E-5 NEO1-PIK1 200 2.02E-5
18 SGTC_1173 0443-0020 4.01 122.0 µM 3.12E-5 TSC3-RPN4 31 3.09E-5
19 SGTC_1696 st025591 3.99 34.8 µM 3.35E-5 SWF1 & branched chain AA biosynthesis 28 3.32E-5
20 SGTC_1350 1495-0454 3.98 146.0 µM 3.41E-5 26 3.38E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.19E-17 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.107 5.61E-10 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.102 3.19E-9 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.099 9.32E-9 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
0.097 1.68E-8 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.097 1.96E-8 YPL205C_d YPL205C_d hom Hypothetical protein; deletion of locus affects telomere length
0.094 5.06E-8 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.092 1.08E-7 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.089 2.06E-7 YAL020C ATS1 hom Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
0.088 3.82E-7 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.086 5.55E-7 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.086 6.20E-7 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.085 7.53E-7 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.085 8.14E-7 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.084 1.07E-6 YLR095C IOC2 hom Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif