YDL048C / STP4

Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL048C / STP4

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.90|P-value:1.45E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.83|P-value:1.62E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-6.64|P-value:3.14E-10 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.84|P-value:1.53E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.34|P-value:8.58E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.34|P-value:2.31E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.39|P-value:2.18E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.66|P-value:2.89E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.88|P-value:1.34E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:6.46|P-value:7.17E-10 ID:SGTC_877|Compound:0771-0151|FD-Score:4.11|P-value:5.57E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.55|P-value:9.72E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.04|P-value:7.48E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.51|P-value:4.84E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.90|P-value:1.23E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-5.29|P-value:4.18E-7 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.29|P-value:9.91E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.63|P-value:3.29E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.20|P-value:3.99E-5 ID:SGTC_1810|Compound:st050138|FD-Score:4.42|P-value:1.65E-5 ID:SGTC_2167|Compound:5876490|FD-Score:-4.55|P-value:1.14E-5 ID:SGTC_2304|Compound:7443016|FD-Score:3.48|P-value:5.28E-4 ID:SGTC_2314|Compound:7727897|FD-Score:5.01|P-value:1.32E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.22|P-value:4.37E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.29|P-value:2.78E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:6.64|P-value:2.37E-10 ID:SGTC_2430|Compound:5571206|FD-Score:-3.75|P-value:2.44E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.41|P-value:6.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.70|P-value:5.39E-20 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.74|P-value:4.36E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.94|P-value:1.07E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.70|P-value:2.88E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.08|P-value:6.31E-5 ID:SGTC_3308|Compound:9128332|FD-Score:5.07|P-value:9.97E-7 ID:SGTC_3339|Compound:9145883|FD-Score:-3.94|P-value:1.23E-4 ID:SGTC_3355|Compound:9151058|FD-Score:4.67|P-value:5.88E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.90|P-value:1.45E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.83|P-value:1.62E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-6.64|P-value:3.14E-10 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.84|P-value:1.53E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.34|P-value:8.58E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.34|P-value:2.31E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.39|P-value:2.18E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.66|P-value:2.89E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.88|P-value:1.34E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:6.46|P-value:7.17E-10 ID:SGTC_877|Compound:0771-0151|FD-Score:4.11|P-value:5.57E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.55|P-value:9.72E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.04|P-value:7.48E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.51|P-value:4.84E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.90|P-value:1.23E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-5.29|P-value:4.18E-7 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.29|P-value:9.91E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.63|P-value:3.29E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.20|P-value:3.99E-5 ID:SGTC_1810|Compound:st050138|FD-Score:4.42|P-value:1.65E-5 ID:SGTC_2167|Compound:5876490|FD-Score:-4.55|P-value:1.14E-5 ID:SGTC_2304|Compound:7443016|FD-Score:3.48|P-value:5.28E-4 ID:SGTC_2314|Compound:7727897|FD-Score:5.01|P-value:1.32E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.22|P-value:4.37E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.29|P-value:2.78E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:6.64|P-value:2.37E-10 ID:SGTC_2430|Compound:5571206|FD-Score:-3.75|P-value:2.44E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.41|P-value:6.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.70|P-value:5.39E-20 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.74|P-value:4.36E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.94|P-value:1.07E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.70|P-value:2.88E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.08|P-value:6.31E-5 ID:SGTC_3308|Compound:9128332|FD-Score:5.07|P-value:9.97E-7 ID:SGTC_3339|Compound:9145883|FD-Score:-3.94|P-value:1.23E-4 ID:SGTC_3355|Compound:9151058|FD-Score:4.67|P-value:5.88E-6

Top fitness defect scores for YDL048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 9.70 100.0 µM 5.39E-20 redox potentiating 70 1.55E-22
2 SGTC_2419 paclitaxel 6.64 166.5 µM 2.37E-10 3 1.53E-11
3 SGTC_709 3807-1509 6.46 243.0 µM 7.17E-10 RSC complex & mRNA processing 2 5.38E-11
4 SGTC_3308 9128332 5.07 17.6 µM 9.97E-7 plasma membrane duress 47 2.02E-7
5 SGTC_2314 7727897 5.01 200.0 µM 1.32E-6 3 2.77E-7
6 SGTC_2688 kanamycin b 4.74 96.7 µM 4.36E-6 calcium & mitochondrial duress 271 1.08E-6
7 SGTC_3355 9151058 4.67 44.0 µM 5.88E-6 RNA processing & uracil transport 5 1.51E-6
8 SGTC_880 0833-0487 4.55 87.2 µM 9.72E-6 mitochondrial processes 11 2.67E-6
9 SGTC_1810 st050138 4.42 53.0 µM 1.65E-5 PDR1 5 4.88E-6
10 SGTC_422 cantharidin 4.34 155.0 µM 2.31E-5 cell wall signaling 44 7.15E-6
11 SGTC_2417 cerulenin 4.29 830.0 nM 2.78E-5 23 8.80E-6
12 SGTC_1789 tunicamycin 4.20 25.0 nM 3.99E-5 unfolded protein response 38 1.33E-5
13 SGTC_877 0771-0151 4.11 33.1 µM 5.57E-5 13 1.94E-5
14 SGTC_3143 9086658 4.08 49.5 µM 6.31E-5 38 2.23E-5
15 SGTC_1056 3448-1962 4.04 115.0 µM 7.48E-5 amide catabolism 22 2.70E-5
16 SGTC_2779 methotrexate 3.94 400.0 µM 1.07E-4 29 4.04E-5
17 SGTC_1178 0988-0033 3.90 191.0 µM 1.23E-4 27 4.76E-5
18 SGTC_568 1193-0097 3.88 7.5 µM 1.34E-4 ERAD & cell cycle 155 5.24E-5
19 SGTC_255 tunicamycin 3.84 200.5 nM 1.53E-4 unfolded protein response 80 6.08E-5
20 SGTC_86 0417-1630 3.83 471.9 µM 1.62E-4 ubiquinone biosynthesis & proteasome 162 6.49E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 6.93E-31 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.196 1.51E-30 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.189 2.11E-28 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.189 2.75E-28 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.182 2.24E-26 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.170 3.07E-23 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.169 6.64E-23 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.169 7.38E-23 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.168 1.66E-22 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.167 2.03E-22 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.166 4.37E-22 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.159 1.59E-20 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.151 1.66E-18 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.148 6.75E-18 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.147 9.38E-18 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences