YDL050C_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL050C / YDL050C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-2.92|P-value:4.19E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.40|P-value:5.68E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.95|P-value:3.67E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.17|P-value:1.42E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.16|P-value:1.52E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.92|P-value:4.42E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:2.87|P-value:5.72E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.16|P-value:1.52E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.92|P-value:4.15E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.65|P-value:1.77E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:3.16|P-value:1.69E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.14|P-value:1.83E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.53|P-value:2.66E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-6.20|P-value:7.25E-13 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.45|P-value:3.99E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.40|P-value:5.68E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.89|P-value:5.38E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.85|P-value:5.45E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:2.77|P-value:8.60E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.97|P-value:3.26E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.25|P-value:6.92E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-2.79|P-value:7.13E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.14|P-value:1.87E-4 ID:SGTC_1603|Compound:st002045|FD-Score:2.88|P-value:5.50E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.03|P-value:2.63E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.27|P-value:1.06E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.96|P-value:3.95E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.56|P-value:2.32E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.73|P-value:9.97E-6 ID:SGTC_2194|Compound:5927483|FD-Score:3.65|P-value:1.73E-5 ID:SGTC_2200|Compound:6600604|FD-Score:3.28|P-value:9.82E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.26|P-value:1.09E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.34|P-value:7.66E-5 ID:SGTC_2478|Compound:5763493|FD-Score:2.89|P-value:5.18E-4 ID:SGTC_2480|Compound:5767542|FD-Score:2.97|P-value:3.87E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.91|P-value:4.68E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.16|P-value:1.74E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.05|P-value:2.74E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.74|P-value:8.67E-4 ID:SGTC_2780|Compound:5215298|FD-Score:2.78|P-value:8.10E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-2.73|P-value:8.70E-4 ID:SGTC_3156|Compound:9099931|FD-Score:2.73|P-value:9.90E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.42|P-value:4.63E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.92|P-value:4.19E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.40|P-value:5.68E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.95|P-value:3.67E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.17|P-value:1.42E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.16|P-value:1.52E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.92|P-value:4.42E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:2.87|P-value:5.72E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.16|P-value:1.52E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.92|P-value:4.15E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.65|P-value:1.77E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:3.16|P-value:1.69E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.14|P-value:1.83E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.53|P-value:2.66E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-6.20|P-value:7.25E-13 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.45|P-value:3.99E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.40|P-value:5.68E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.89|P-value:5.38E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.85|P-value:5.45E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:2.77|P-value:8.60E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.97|P-value:3.26E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.25|P-value:6.92E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-2.79|P-value:7.13E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.14|P-value:1.87E-4 ID:SGTC_1603|Compound:st002045|FD-Score:2.88|P-value:5.50E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.03|P-value:2.63E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.27|P-value:1.06E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.96|P-value:3.95E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.56|P-value:2.32E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.73|P-value:9.97E-6 ID:SGTC_2194|Compound:5927483|FD-Score:3.65|P-value:1.73E-5 ID:SGTC_2200|Compound:6600604|FD-Score:3.28|P-value:9.82E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.26|P-value:1.09E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.34|P-value:7.66E-5 ID:SGTC_2478|Compound:5763493|FD-Score:2.89|P-value:5.18E-4 ID:SGTC_2480|Compound:5767542|FD-Score:2.97|P-value:3.87E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.91|P-value:4.68E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.16|P-value:1.74E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.05|P-value:2.74E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.74|P-value:8.67E-4 ID:SGTC_2780|Compound:5215298|FD-Score:2.78|P-value:8.10E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-2.73|P-value:8.70E-4 ID:SGTC_3156|Compound:9099931|FD-Score:2.73|P-value:9.90E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.42|P-value:4.63E-5

Top fitness defect scores for YDL050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1212 0520-0165 4.25 585.0 µM 6.92E-7 20 1.06E-5
2 SGTC_1200 1643-0193 3.97 18.4 µM 3.26E-6 16 3.55E-5
3 SGTC_457 grayanotoxin iii 3.95 135.0 µM 3.67E-6 67 3.89E-5
4 SGTC_618 k072-0232 3.92 33.2 µM 4.42E-6 60S ribosome export 7 4.50E-5
5 SGTC_2572 astragaloside iv 3.91 100.0 µM 4.68E-6 27 4.71E-5
6 SGTC_2194 5927483 3.65 104.5 µM 1.73E-5 23 1.31E-4
7 SGTC_666 0272-0154 3.65 136.0 µM 1.77E-5 cell wall 69 1.33E-4
8 SGTC_213 1246-0773 3.40 967.0 nM 5.68E-5 41 3.33E-4
9 SGTC_930 2810-3379 3.40 265.0 µM 5.68E-5 24 3.34E-4
10 SGTC_2284 7945075 3.34 39.2 µM 7.66E-5 mitochondrial processes 49 4.22E-4
11 SGTC_2200 6600604 3.28 21.9 µM 9.82E-5 tubulin folding & SWR complex 76 5.12E-4
12 SGTC_1984 st072354 3.27 53.1 µM 1.06E-4 33 5.43E-4
13 SGTC_2281 7943571 3.26 200.0 µM 1.09E-4 24 5.57E-4
14 SGTC_668 1682-0499 3.16 62.6 µM 1.69E-4 60 7.84E-4
15 SGTC_2584 androsterone 3.16 48.7 µM 1.74E-4 cell wall 196 8.02E-4
16 SGTC_743 1275-0778 3.14 158.0 µM 1.83E-4 excess fatty acid 77 8.36E-4
17 SGTC_1224 0823-0416 3.14 294.0 µM 1.87E-4 40 8.51E-4
18 SGTC_2693 st077581 3.05 40.7 µM 2.74E-4 88 0.00115
19 SGTC_2480 5767542 2.97 37.2 µM 3.87E-4 48 0.00151
20 SGTC_2076 5212012 2.96 200.0 µM 3.95E-4 23 0.00153

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.09E-22 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.122 1.23E-12 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.119 5.17E-12 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.112 7.89E-11 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.101 4.68E-9 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.101 5.18E-9 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.099 1.10E-8 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.098 1.38E-8 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.098 1.49E-8 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.097 1.99E-8 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.096 2.15E-8 YPL026C SKS1 hom Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
0.096 2.87E-8 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.095 3.85E-8 YJL104W PAM16 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
0.093 6.08E-8 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.092 9.10E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress