YDL052C / SLC1

1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL052C / SLC1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.10|P-value:1.07E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.70|P-value:3.06E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.38|P-value:8.68E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:7.27|P-value:6.17E-12 ID:SGTC_152|Compound:4469-0003|FD-Score:10.80|P-value:5.38E-24 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.64|P-value:2.83E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.85|P-value:1.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.88|P-value:2.19E-8 ID:SGTC_345|Compound:1362-0200|FD-Score:3.35|P-value:9.71E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.85|P-value:1.36E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.82|P-value:1.52E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:7.95|P-value:6.14E-14 ID:SGTC_555|Compound:4296-0685|FD-Score:3.44|P-value:7.30E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.61|P-value:4.11E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.42|P-value:2.03E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.50|P-value:4.60E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.92|P-value:1.02E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.26|P-value:3.90E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.43|P-value:7.38E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.91|P-value:1.42E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.95|P-value:2.16E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:5.13|P-value:9.26E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.89|P-value:1.15E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.33|P-value:1.94E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.36|P-value:2.62E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.73|P-value:5.55E-6 ID:SGTC_1610|Compound:st001799|FD-Score:-3.32|P-value:8.18E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.50|P-value:4.51E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.56|P-value:3.69E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.86|P-value:1.75E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.80|P-value:2.12E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-5.75|P-value:2.86E-8 ID:SGTC_1917|Compound:st066507|FD-Score:-7.18|P-value:6.60E-12 ID:SGTC_1919|Compound:st067113|FD-Score:-9.90|P-value:6.09E-21 ID:SGTC_1941|Compound:st076221|FD-Score:-3.91|P-value:1.09E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.80|P-value:2.12E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-4.08|P-value:5.68E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.49|P-value:6.20E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.40|P-value:8.24E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.41|P-value:2.11E-5 ID:SGTC_2061|Compound:5245884|FD-Score:-4.20|P-value:3.54E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.58|P-value:1.06E-5 ID:SGTC_2069|Compound:5228469|FD-Score:-6.54|P-value:3.54E-10 ID:SGTC_2281|Compound:7943571|FD-Score:3.97|P-value:1.16E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.46|P-value:6.72E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.79|P-value:2.21E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.38|P-value:8.91E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.48|P-value:1.63E-5 ID:SGTC_2505|Compound:galangin|FD-Score:-3.49|P-value:4.72E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.49|P-value:4.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.23|P-value:2.12E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.28|P-value:2.60E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.10|P-value:6.15E-30 ID:SGTC_2834|Compound:9001755|FD-Score:-4.11|P-value:5.02E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.52|P-value:4.30E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.82|P-value:1.49E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.45|P-value:6.99E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.86|P-value:1.70E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.10|P-value:1.07E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.70|P-value:3.06E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.38|P-value:8.68E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:7.27|P-value:6.17E-12 ID:SGTC_152|Compound:4469-0003|FD-Score:10.80|P-value:5.38E-24 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.64|P-value:2.83E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.85|P-value:1.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.88|P-value:2.19E-8 ID:SGTC_345|Compound:1362-0200|FD-Score:3.35|P-value:9.71E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.85|P-value:1.36E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.82|P-value:1.52E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:7.95|P-value:6.14E-14 ID:SGTC_555|Compound:4296-0685|FD-Score:3.44|P-value:7.30E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.61|P-value:4.11E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.42|P-value:2.03E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.50|P-value:4.60E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.92|P-value:1.02E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.26|P-value:3.90E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.43|P-value:7.38E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.91|P-value:1.42E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.95|P-value:2.16E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:5.13|P-value:9.26E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.89|P-value:1.15E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.33|P-value:1.94E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.36|P-value:2.62E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.73|P-value:5.55E-6 ID:SGTC_1610|Compound:st001799|FD-Score:-3.32|P-value:8.18E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.50|P-value:4.51E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.56|P-value:3.69E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.86|P-value:1.75E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.80|P-value:2.12E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-5.75|P-value:2.86E-8 ID:SGTC_1917|Compound:st066507|FD-Score:-7.18|P-value:6.60E-12 ID:SGTC_1919|Compound:st067113|FD-Score:-9.90|P-value:6.09E-21 ID:SGTC_1941|Compound:st076221|FD-Score:-3.91|P-value:1.09E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.80|P-value:2.12E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-4.08|P-value:5.68E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.49|P-value:6.20E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.40|P-value:8.24E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.41|P-value:2.11E-5 ID:SGTC_2061|Compound:5245884|FD-Score:-4.20|P-value:3.54E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.58|P-value:1.06E-5 ID:SGTC_2069|Compound:5228469|FD-Score:-6.54|P-value:3.54E-10 ID:SGTC_2281|Compound:7943571|FD-Score:3.97|P-value:1.16E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.46|P-value:6.72E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.79|P-value:2.21E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.38|P-value:8.91E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.48|P-value:1.63E-5 ID:SGTC_2505|Compound:galangin|FD-Score:-3.49|P-value:4.72E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.49|P-value:4.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.23|P-value:2.12E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.28|P-value:2.60E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.10|P-value:6.15E-30 ID:SGTC_2834|Compound:9001755|FD-Score:-4.11|P-value:5.02E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.52|P-value:4.30E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.82|P-value:1.49E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.45|P-value:6.99E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.86|P-value:1.70E-4

Top fitness defect scores for YDL052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 12.10 96.7 µM 6.15E-30 calcium & mitochondrial duress 11 4.77E-34
2 SGTC_152 4469-0003 10.80 551.2 µM 5.38E-24 2 2.92E-27
3 SGTC_363 0455-0021 7.95 3.1 µM 6.14E-14 azole & statin 13 9.05E-16
4 SGTC_146 3448-8650 7.27 53.1 µM 6.17E-12 NEO1-PIK1 34 1.75E-13
5 SGTC_1239 0337-0584 6.33 35.4 µM 1.94E-9 unfolded protein response 13 1.25E-10
6 SGTC_310 1273-0058 5.88 1.1 µM 2.19E-8 mitochondrial stress 148 2.00E-9
7 SGTC_1212 0520-0165 5.13 585.0 µM 9.26E-7 6 1.45E-7
8 SGTC_8 0354-0001 5.10 70.0 µM 1.07E-6 40 1.70E-7
9 SGTC_1205 4161-2785 4.95 76.0 µM 2.16E-6 13 3.81E-7
10 SGTC_1439 4092-1168 4.73 46.0 µM 5.55E-6 2 1.12E-6
11 SGTC_2064 5220758 4.58 200.0 µM 1.06E-5 19 2.33E-6
12 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.48 3.7 µM 1.63E-5 53 3.81E-6
13 SGTC_805 3852-0218 4.42 479.0 µM 2.03E-5 ERAD & cell cycle 51 4.91E-6
14 SGTC_1984 st072354 4.41 53.1 µM 2.11E-5 7 5.13E-6
15 SGTC_1250 0485-0349 4.36 40.2 µM 2.62E-5 22 6.57E-6
16 SGTC_1056 3448-1962 4.26 115.0 µM 3.90E-5 amide catabolism 17 1.04E-5
17 SGTC_2281 7943571 3.97 200.0 µM 1.16E-4 10 3.60E-5
18 SGTC_1195 1502-0147 3.91 41.1 µM 1.42E-4 30 4.54E-5
19 SGTC_3290 9121031 3.86 71.4 µM 1.70E-4 15 5.56E-5
20 SGTC_1853 st056710 3.86 91.2 µM 1.75E-4 amide catabolism 28 5.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 1.89E-30 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.186 1.29E-27 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.179 1.21E-25 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.159 2.03E-20 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.155 2.03E-19 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.154 3.08E-19 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 1.23E-18 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.151 1.40E-18 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.148 8.47E-18 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.147 8.75E-18 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.145 3.65E-17 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.141 1.87E-16 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.134 6.22E-15 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.132 2.06E-14 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.127 1.90E-13 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds