YDL055C / PSA1

GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL055C / PSA1

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:-3.06|P-value:7.16E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.15|P-value:5.08E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.15|P-value:5.85E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:4.24|P-value:5.87E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.53|P-value:1.37E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.01|P-value:9.59E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.13|P-value:6.11E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.00|P-value:9.88E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.04|P-value:7.69E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.02|P-value:8.21E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.47|P-value:1.51E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.41|P-value:2.14E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.15|P-value:5.15E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.02|P-value:9.10E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.50|P-value:1.52E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-4.69|P-value:5.35E-7 ID:SGTC_1615|Compound:st002656|FD-Score:-2.98|P-value:9.66E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.27|P-value:3.33E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.66|P-value:7.76E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-3.18|P-value:4.65E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.03|P-value:9.04E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.26|P-value:5.40E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.95|P-value:1.95E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.81|P-value:4.12E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.00|P-value:9.71E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.20|P-value:4.23E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.82|P-value:4.09E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.16|P-value:5.53E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.00|P-value:8.79E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.59|P-value:9.11E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.09|P-value:7.13E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-2.98|P-value:9.57E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.35|P-value:2.45E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.56|P-value:1.07E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:3.78|P-value:4.83E-5 ID:SGTC_2734|Compound:clemastine|FD-Score:3.98|P-value:1.94E-5 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.38|P-value:2.48E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.09|P-value:7.26E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.42|P-value:2.46E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.11|P-value:5.96E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.02|P-value:9.19E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.34|P-value:2.86E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:1.64E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.01|P-value:8.51E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.49|P-value:1.39E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.06|P-value:7.93E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.15|P-value:9.06E-6 ID:SGTC_3337|Compound:9144342|FD-Score:3.33|P-value:3.00E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.06|P-value:7.16E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.15|P-value:5.08E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.15|P-value:5.85E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:4.24|P-value:5.87E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.53|P-value:1.37E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.01|P-value:9.59E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.13|P-value:6.11E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.00|P-value:9.88E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.04|P-value:7.69E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.02|P-value:8.21E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.47|P-value:1.51E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.41|P-value:2.14E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.15|P-value:5.15E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.02|P-value:9.10E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.50|P-value:1.52E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-4.69|P-value:5.35E-7 ID:SGTC_1615|Compound:st002656|FD-Score:-2.98|P-value:9.66E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.27|P-value:3.33E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.66|P-value:7.76E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-3.18|P-value:4.65E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.03|P-value:9.04E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.26|P-value:5.40E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.95|P-value:1.95E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.81|P-value:4.12E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.00|P-value:9.71E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.20|P-value:4.23E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.82|P-value:4.09E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.16|P-value:5.53E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.00|P-value:8.79E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.59|P-value:9.11E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.09|P-value:7.13E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-2.98|P-value:9.57E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.35|P-value:2.45E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.56|P-value:1.07E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:3.78|P-value:4.83E-5 ID:SGTC_2734|Compound:clemastine|FD-Score:3.98|P-value:1.94E-5 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.38|P-value:2.48E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.09|P-value:7.26E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.42|P-value:2.46E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.11|P-value:5.96E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.02|P-value:9.19E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.34|P-value:2.86E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:1.64E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.01|P-value:8.51E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.49|P-value:1.39E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.06|P-value:7.93E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.15|P-value:9.06E-6 ID:SGTC_3337|Compound:9144342|FD-Score:3.33|P-value:3.00E-4

Top fitness defect scores for YDL055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2815 7968870 4.42 71.4 µM 2.46E-6 4 4.90E-6 0.33
2 SGTC_2305 7443522 4.26 69.2 µM 5.40E-6 6 1.02E-5 0.42
3 SGTC_415 dibenzyl ketone 4.24 100.0 µM 5.87E-6 2 1.10E-5 0.39
4 SGTC_3327 9140648 4.15 26.9 µM 9.06E-6 10 1.66E-5 0.04
5 SGTC_2734 clemastine 3.98 41.6 µM 1.94E-5 ERG2 2 3.38E-5 0.39
6 SGTC_2414 st077232 3.82 92.9 µM 4.09E-5 6 6.80E-5 0.02
7 SGTC_2316 5844804 3.81 197.4 µM 4.12E-5 11 6.85E-5 0.09
8 SGTC_2731 amoxapine 3.78 43.4 µM 4.83E-5 3 7.95E-5 0.39
9 SGTC_2126 5251174 3.66 33.9 µM 7.76E-5 9 1.24E-4 4.63E-4
10 SGTC_2839 9003951 3.53 26.0 µM 1.36E-4 5 2.10E-4 0.03
11 SGTC_818 4072-2707 3.53 53.5 µM 1.37E-4 12 2.11E-4 0.01
12 SGTC_1608 st001473 3.50 40.5 µM 1.52E-4 9 2.33E-4 0.05
13 SGTC_1473 k844-0725 3.49 134.0 µM 1.58E-4 9 2.42E-4 0.03
14 SGTC_2949 9072542 3.48 2.2 µM 1.64E-4 TSC3-RPN4 18 2.50E-4 0.00
15 SGTC_2689 tacrolimus 3.45 100.0 µM 1.87E-4 19 2.83E-4 0.04
16 SGTC_1287 0971-0001 3.41 34.6 µM 2.14E-4 sphingolipid biosynthesis & PDR1 6 3.22E-4 0.03
17 SGTC_2735 sertaconazole 3.38 140.0 nM 2.48E-4 plasma membrane duress 6 3.69E-4 0.02
18 SGTC_2885 9057732 3.34 52.0 µM 2.86E-4 7 4.22E-4 0.14
19 SGTC_3337 9144342 3.33 33.5 µM 3.00E-4 17 4.40E-4 0.14
20 SGTC_752 1896-0090 3.25 130.0 µM 4.00E-4 TSC3-RPN4 11 5.78E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.22E-13 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.103 1.84E-9 YNL304W YPT11 hom Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
0.101 5.10E-9 YDL084W SUB2 het Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.100 6.30E-9 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.082 1.78E-6 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.082 1.86E-6 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.081 2.33E-6 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.080 3.27E-6 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.077 8.57E-6 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.075 1.33E-5 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.075 1.44E-5 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.075 1.55E-5 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.073 2.62E-5 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.070 4.40E-5 YMR301C ATM1 het Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
0.070 5.03E-5 YKL214C YRA2 hom Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus