HIPHOP chemogenomics database

YDL056W / MBP1

Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL056W / MBP1

Click on Significant Values for Screen Details

Top fitness defect scores for YDL056W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	14.30	5.3 µM	4.73E-37		112	1.08E-46
2	SGTC_275	trichlorophene	11.20	5.7 µM	1.11E-23	mitochondrial stress	32	1.44E-29
3	SGTC_949	1165-0505	9.35	146.0 µM	4.71E-17		3	4.20E-21
4	SGTC_1622	st003707	8.71	19.4 µM	4.93E-15	calcium & mitochondrial duress	6	1.58E-18
5	SGTC_1627	st003713	8.09	25.6 µM	3.06E-13	calcium & mitochondrial duress	15	3.03E-16
6	SGTC_956	1185-0240	7.92	191.0 µM	9.22E-13		2	1.23E-15
7	SGTC_1623	st003709	7.10	20.3 µM	1.21E-10	calcium & mitochondrial duress	8	6.04E-13
8	SGTC_908	3448-7491	6.51	47.7 µM	3.08E-9	mitochondrial stress	36	3.68E-11
9	SGTC_1615	st002656	6.43	86.5 µM	4.79E-9	redox potentiating	2	6.44E-11
10	SGTC_2112	5488546	6.20	200.0 µM	1.56E-8	TSC3-RPN4	3	2.87E-10
11	SGTC_173	1273-0061	5.92	2.7 µM	6.11E-8	mitochondrial stress	112	1.61E-9
12	SGTC_120	rhodamine 6G	5.73	52.3 µM	1.50E-7	mitochondrial processes	10	5.03E-9
13	SGTC_10	0279-0212	5.30	42.6 µM	1.06E-6	TRP & mitochondrial translation	48	5.94E-8
14	SGTC_118	0083-0097	5.14	135.3 µM	2.09E-6	translation	49	1.39E-7
15	SGTC_2556	citropten	4.90	84.6 µM	5.60E-6		11	4.81E-7
16	SGTC_1883	5-benzylidenerhodanine	4.86	20.0 µM	6.57E-6	TRP & mitochondrial translation	36	5.88E-7
17	SGTC_965	1291-5240	4.72	308.0 µM	1.16E-5		15	1.19E-6
18	SGTC_1500	4488-1866	4.71	171.0 µM	1.17E-5	RPP1 & pyrimidine depletion	5	1.21E-6
19	SGTC_310	1273-0058	4.58	1.1 µM	1.99E-5	mitochondrial stress	204	2.37E-6
20	SGTC_1108	betulinic acid	4.38	729.1 nM	4.13E-5		9	5.91E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.422	3.65E-145	YDR296W	MHR1	hom	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.407	1.05E-133	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.407	7.41E-134	YOL095C	HMI1	hom	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.406	4.05E-133	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.393	1.39E-124	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.393	1.39E-124	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.387	1.97E-120	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.386	9.75E-120	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.380	1.24E-115	YPL029W	SUV3	hom	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.377	1.01E-113	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.370	1.68E-109	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.370	2.32E-109	YBL038W	MRPL16	hom	Mitochondrial ribosomal protein of the large subunit
0.369	1.09E-108	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.366	4.54E-107	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.365	2.21E-106	YIL093C	RSM25	hom	Mitochondrial ribosomal protein of the small subunit