Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDL056W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.422 | 3.65E-145 | YDR296W | MHR1 | hom | Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress |
0.407 | 1.05E-133 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.407 | 7.41E-134 | YOL095C | HMI1 | hom | Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD |
0.406 | 4.05E-133 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.393 | 1.39E-124 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
0.393 | 1.39E-124 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
0.387 | 1.97E-120 | YPR166C | MRP2 | hom | Mitochondrial ribosomal protein of the small subunit |
0.386 | 9.75E-120 | YDR518W | EUG1 | hom | Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER |
0.380 | 1.24E-115 | YPL029W | SUV3 | hom | ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron |
0.377 | 1.01E-113 | YNL252C | MRPL17 | hom | Mitochondrial ribosomal protein of the large subunit |
0.370 | 1.68E-109 | YNL184C_p | YNL184C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
0.370 | 2.32E-109 | YBL038W | MRPL16 | hom | Mitochondrial ribosomal protein of the large subunit |
0.369 | 1.09E-108 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.366 | 4.54E-107 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |
0.365 | 2.21E-106 | YIL093C | RSM25 | hom | Mitochondrial ribosomal protein of the small subunit |