YDL056W / MBP1

Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL056W / MBP1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.30|P-value:1.06E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.44|P-value:9.45E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-4.53|P-value:4.74E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.14|P-value:2.09E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.09|P-value:1.15E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.73|P-value:1.50E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:4.13|P-value:9.97E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-8.06|P-value:1.18E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:5.92|P-value:6.11E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:14.30|P-value:4.73E-37 ID:SGTC_251|Compound:melphalan|FD-Score:3.51|P-value:7.60E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.59|P-value:3.79E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:-5.42|P-value:1.42E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.14|P-value:1.86E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-4.08|P-value:2.24E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.20|P-value:1.11E-23 ID:SGTC_310|Compound:1273-0058|FD-Score:4.58|P-value:1.99E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.94|P-value:1.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.85|P-value:4.71E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.73|P-value:2.27E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.49|P-value:8.13E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.92|P-value:3.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.51|P-value:3.08E-9 ID:SGTC_949|Compound:1165-0505|FD-Score:9.35|P-value:4.71E-17 ID:SGTC_956|Compound:1185-0240|FD-Score:7.92|P-value:9.22E-13 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.68|P-value:7.96E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-5.69|P-value:4.18E-7 ID:SGTC_965|Compound:1291-5240|FD-Score:4.72|P-value:1.16E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.51|P-value:7.62E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.04|P-value:1.38E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.38|P-value:4.13E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.94|P-value:1.94E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.90|P-value:2.22E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.34|P-value:4.85E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.44|P-value:9.26E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.31|P-value:5.31E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.27|P-value:1.19E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.85|P-value:2.57E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.71|P-value:1.17E-5 ID:SGTC_1615|Compound:st002656|FD-Score:6.43|P-value:4.79E-9 ID:SGTC_1622|Compound:st003707|FD-Score:8.71|P-value:4.93E-15 ID:SGTC_1623|Compound:st003709|FD-Score:7.10|P-value:1.21E-10 ID:SGTC_1624|Compound:st003710|FD-Score:3.65|P-value:4.93E-4 ID:SGTC_1627|Compound:st003713|FD-Score:8.09|P-value:3.06E-13 ID:SGTC_1658|Compound:st012944|FD-Score:-4.02|P-value:2.76E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.43|P-value:1.36E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.86|P-value:6.57E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.94|P-value:1.95E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.80|P-value:3.09E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-4.05|P-value:2.51E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.63|P-value:9.24E-4 ID:SGTC_2112|Compound:5488546|FD-Score:6.20|P-value:1.56E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.65|P-value:4.92E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.16|P-value:9.26E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.64|P-value:5.07E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.67|P-value:8.27E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.78|P-value:1.91E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-5.53|P-value:8.87E-7 ID:SGTC_2448|Compound:5185112|FD-Score:4.18|P-value:8.44E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.13|P-value:1.95E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.81|P-value:5.32E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.90|P-value:5.60E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.67|P-value:8.28E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.56|P-value:6.53E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.69|P-value:7.77E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.43|P-value:9.62E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.10|P-value:1.13E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.18|P-value:8.58E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-5.35|P-value:1.85E-6 ID:SGTC_3292|Compound:9120825|FD-Score:4.29|P-value:5.66E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-6.26|P-value:2.94E-8 ID:SGTC_3296|Compound:9122258|FD-Score:-3.98|P-value:3.17E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.43|P-value:9.70E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.30|P-value:1.06E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.44|P-value:9.45E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-4.53|P-value:4.74E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.14|P-value:2.09E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.09|P-value:1.15E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.73|P-value:1.50E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:4.13|P-value:9.97E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-8.06|P-value:1.18E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:5.92|P-value:6.11E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:14.30|P-value:4.73E-37 ID:SGTC_251|Compound:melphalan|FD-Score:3.51|P-value:7.60E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.59|P-value:3.79E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:-5.42|P-value:1.42E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.14|P-value:1.86E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-4.08|P-value:2.24E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.20|P-value:1.11E-23 ID:SGTC_310|Compound:1273-0058|FD-Score:4.58|P-value:1.99E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.94|P-value:1.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.85|P-value:4.71E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.73|P-value:2.27E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.49|P-value:8.13E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.92|P-value:3.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.51|P-value:3.08E-9 ID:SGTC_949|Compound:1165-0505|FD-Score:9.35|P-value:4.71E-17 ID:SGTC_956|Compound:1185-0240|FD-Score:7.92|P-value:9.22E-13 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.68|P-value:7.96E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-5.69|P-value:4.18E-7 ID:SGTC_965|Compound:1291-5240|FD-Score:4.72|P-value:1.16E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.51|P-value:7.62E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.04|P-value:1.38E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.38|P-value:4.13E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.94|P-value:1.94E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.90|P-value:2.22E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.34|P-value:4.85E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.44|P-value:9.26E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.31|P-value:5.31E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.27|P-value:1.19E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.85|P-value:2.57E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.71|P-value:1.17E-5 ID:SGTC_1615|Compound:st002656|FD-Score:6.43|P-value:4.79E-9 ID:SGTC_1622|Compound:st003707|FD-Score:8.71|P-value:4.93E-15 ID:SGTC_1623|Compound:st003709|FD-Score:7.10|P-value:1.21E-10 ID:SGTC_1624|Compound:st003710|FD-Score:3.65|P-value:4.93E-4 ID:SGTC_1627|Compound:st003713|FD-Score:8.09|P-value:3.06E-13 ID:SGTC_1658|Compound:st012944|FD-Score:-4.02|P-value:2.76E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.43|P-value:1.36E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.86|P-value:6.57E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.94|P-value:1.95E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.80|P-value:3.09E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-4.05|P-value:2.51E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.63|P-value:9.24E-4 ID:SGTC_2112|Compound:5488546|FD-Score:6.20|P-value:1.56E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.65|P-value:4.92E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.16|P-value:9.26E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.64|P-value:5.07E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.67|P-value:8.27E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.78|P-value:1.91E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-5.53|P-value:8.87E-7 ID:SGTC_2448|Compound:5185112|FD-Score:4.18|P-value:8.44E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.13|P-value:1.95E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.81|P-value:5.32E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.90|P-value:5.60E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.67|P-value:8.28E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.56|P-value:6.53E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.69|P-value:7.77E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.43|P-value:9.62E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.10|P-value:1.13E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.18|P-value:8.58E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-5.35|P-value:1.85E-6 ID:SGTC_3292|Compound:9120825|FD-Score:4.29|P-value:5.66E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-6.26|P-value:2.94E-8 ID:SGTC_3296|Compound:9122258|FD-Score:-3.98|P-value:3.17E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.43|P-value:9.70E-4

Top fitness defect scores for YDL056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.30 5.3 µM 4.73E-37 112 1.08E-46
2 SGTC_275 trichlorophene 11.20 5.7 µM 1.11E-23 mitochondrial stress 32 1.44E-29
3 SGTC_949 1165-0505 9.35 146.0 µM 4.71E-17 3 4.20E-21
4 SGTC_1622 st003707 8.71 19.4 µM 4.93E-15 calcium & mitochondrial duress 6 1.58E-18
5 SGTC_1627 st003713 8.09 25.6 µM 3.06E-13 calcium & mitochondrial duress 15 3.03E-16
6 SGTC_956 1185-0240 7.92 191.0 µM 9.22E-13 2 1.23E-15
7 SGTC_1623 st003709 7.10 20.3 µM 1.21E-10 calcium & mitochondrial duress 8 6.04E-13
8 SGTC_908 3448-7491 6.51 47.7 µM 3.08E-9 mitochondrial stress 36 3.68E-11
9 SGTC_1615 st002656 6.43 86.5 µM 4.79E-9 redox potentiating 2 6.44E-11
10 SGTC_2112 5488546 6.20 200.0 µM 1.56E-8 TSC3-RPN4 3 2.87E-10
11 SGTC_173 1273-0061 5.92 2.7 µM 6.11E-8 mitochondrial stress 112 1.61E-9
12 SGTC_120 rhodamine 6G 5.73 52.3 µM 1.50E-7 mitochondrial processes 10 5.03E-9
13 SGTC_10 0279-0212 5.30 42.6 µM 1.06E-6 TRP & mitochondrial translation 48 5.94E-8
14 SGTC_118 0083-0097 5.14 135.3 µM 2.09E-6 translation 49 1.39E-7
15 SGTC_2556 citropten 4.90 84.6 µM 5.60E-6 11 4.81E-7
16 SGTC_1883 5-benzylidenerhodanine 4.86 20.0 µM 6.57E-6 TRP & mitochondrial translation 36 5.88E-7
17 SGTC_965 1291-5240 4.72 308.0 µM 1.16E-5 15 1.19E-6
18 SGTC_1500 4488-1866 4.71 171.0 µM 1.17E-5 RPP1 & pyrimidine depletion 5 1.21E-6
19 SGTC_310 1273-0058 4.58 1.1 µM 1.99E-5 mitochondrial stress 204 2.37E-6
20 SGTC_1108 betulinic acid 4.38 729.1 nM 4.13E-5 9 5.91E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.422 3.65E-145 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.407 1.05E-133 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.407 7.41E-134 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.406 4.05E-133 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.393 1.39E-124 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.393 1.39E-124 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.387 1.97E-120 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.386 9.75E-120 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.380 1.24E-115 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.377 1.01E-113 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.370 1.68E-109 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.370 2.32E-109 YBL038W MRPL16 hom Mitochondrial ribosomal protein of the large subunit
0.369 1.09E-108 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.366 4.54E-107 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.365 2.21E-106 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit