YDL057W_p

Putative protein of unknown function; YDL057W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL057W / YDL057W

Click on Significant Values for Screen Details ID:SGTC_313|Compound:3474-0040|FD-Score:2.85|P-value:8.64E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.05|P-value:4.57E-6 ID:SGTC_489|Compound:paxilline|FD-Score:4.06|P-value:4.23E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:3.25|P-value:1.81E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.60|P-value:2.34E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.86|P-value:1.16E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.31|P-value:1.37E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.71|P-value:2.38E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.27|P-value:2.06E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.16|P-value:3.34E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.26|P-value:2.20E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.13|P-value:3.77E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.00|P-value:4.89E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.12|P-value:3.02E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.53|P-value:7.14E-5 ID:SGTC_1745|Compound:st081495|FD-Score:2.93|P-value:6.41E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.04|P-value:4.24E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-5.02|P-value:2.97E-8 ID:SGTC_2148|Compound:5546263|FD-Score:-3.57|P-value:5.88E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-3.04|P-value:5.32E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.90|P-value:7.04E-4 ID:SGTC_2321|Compound:7390090|FD-Score:2.98|P-value:5.30E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.03|P-value:4.32E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.07|P-value:4.14E-6 ID:SGTC_2359|Compound:9039622|FD-Score:3.14|P-value:2.83E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.37|P-value:1.44E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.37|P-value:8.36E-7 ID:SGTC_2425|Compound:5628681|FD-Score:3.56|P-value:4.61E-5 ID:SGTC_2429|Compound:5902844|FD-Score:2.90|P-value:7.10E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.50|P-value:6.02E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.44|P-value:1.06E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.02|P-value:7.13E-6 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.62|P-value:4.72E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.61|P-value:3.67E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.45|P-value:7.56E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.35|P-value:1.54E-4 ID:SGTC_3080|Compound:9117754|FD-Score:2.82|P-value:9.53E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.42|P-value:8.75E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.09|P-value:3.60E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.68|P-value:3.68E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.67|P-value:2.86E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-4.49|P-value:6.42E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:2.85|P-value:8.64E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.05|P-value:4.57E-6 ID:SGTC_489|Compound:paxilline|FD-Score:4.06|P-value:4.23E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:3.25|P-value:1.81E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.60|P-value:2.34E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.86|P-value:1.16E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.31|P-value:1.37E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.71|P-value:2.38E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.27|P-value:2.06E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.16|P-value:3.34E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.26|P-value:2.20E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.13|P-value:3.77E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.00|P-value:4.89E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.12|P-value:3.02E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.53|P-value:7.14E-5 ID:SGTC_1745|Compound:st081495|FD-Score:2.93|P-value:6.41E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.04|P-value:4.24E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-5.02|P-value:2.97E-8 ID:SGTC_2148|Compound:5546263|FD-Score:-3.57|P-value:5.88E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-3.04|P-value:5.32E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.90|P-value:7.04E-4 ID:SGTC_2321|Compound:7390090|FD-Score:2.98|P-value:5.30E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.03|P-value:4.32E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.07|P-value:4.14E-6 ID:SGTC_2359|Compound:9039622|FD-Score:3.14|P-value:2.83E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.37|P-value:1.44E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.37|P-value:8.36E-7 ID:SGTC_2425|Compound:5628681|FD-Score:3.56|P-value:4.61E-5 ID:SGTC_2429|Compound:5902844|FD-Score:2.90|P-value:7.10E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.50|P-value:6.02E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.44|P-value:1.06E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.02|P-value:7.13E-6 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.62|P-value:4.72E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.61|P-value:3.67E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.45|P-value:7.56E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.35|P-value:1.54E-4 ID:SGTC_3080|Compound:9117754|FD-Score:2.82|P-value:9.53E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.42|P-value:8.75E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.09|P-value:3.60E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.68|P-value:3.68E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.67|P-value:2.86E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-4.49|P-value:6.42E-7

Top fitness defect scores for YDL057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_701 4424-0219 4.60 185.0 µM 2.34E-7 calcium & mitochondrial duress 15 2.10E-6
2 SGTC_2419 paclitaxel 4.37 166.5 µM 8.36E-7 25 6.16E-6
3 SGTC_3200 9114385 4.09 49.5 µM 3.60E-6 28 2.12E-5
4 SGTC_2344 7990960 4.07 77.0 µM 4.14E-6 25 2.38E-5
5 SGTC_489 paxilline 4.06 115.0 µM 4.23E-6 PDR1 12 2.43E-5
6 SGTC_390 dec-rvkr-cmk 4.05 16.7 µM 4.57E-6 calcium & mitochondrial duress 21 2.59E-5
7 SGTC_1030 k029-0042 3.86 36.7 µM 1.16E-5 TSC3-RPN4 28 5.71E-5
8 SGTC_1080 nisoldipine 3.71 24.4 µM 2.38E-5 TSC3-RPN4 34 1.05E-4
9 SGTC_3225 9130819 3.67 49.5 µM 2.86E-5 amide catabolism 37 1.22E-4
10 SGTC_2736 butenafine 3.61 14.7 µM 3.67E-5 38 1.51E-4
11 SGTC_2425 5628681 3.56 7.8 µM 4.61E-5 39 1.83E-4
12 SGTC_2646 retinol 3.50 96.8 µM 6.02E-5 21 2.29E-4
13 SGTC_2811 7967822 3.45 32.5 µM 7.56E-5 30 2.78E-4
14 SGTC_3152 9099253 3.42 49.5 µM 8.75E-5 NEO1-PIK1 165 3.15E-4
15 SGTC_1067 clotrimazole 3.31 1.4 µM 1.37E-4 azole & statin 67 4.60E-4
16 SGTC_656 4090-1979 3.25 187.0 µM 1.81E-4 45 5.82E-4
17 SGTC_2359 9039622 3.14 200.0 µM 2.83E-4 endomembrane recycling 57 8.51E-4
18 SGTC_1586 deoxycorticosterone acetate 3.12 53.7 µM 3.02E-4 36 9.00E-4
19 SGTC_1990 st072050 3.04 59.8 µM 4.24E-4 44 0.00120
20 SGTC_2342 7990637 3.03 118.9 µM 4.32E-4 RNA processing & uracil transport 84 0.00122

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.45E-15 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
0.133 1.02E-14 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.132 1.90E-14 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.128 9.39E-14 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.127 1.73E-13 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.115 2.22E-11 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.115 2.41E-11 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.110 1.76E-10 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.110 1.76E-10 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.107 5.76E-10 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.106 6.46E-10 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.106 7.95E-10 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.105 1.21E-9 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.102 3.80E-9 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.102 3.78E-9 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies