YDL060W / TSR1

Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL060W / TSR1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-3.32|P-value:1.67E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-10.20|P-value:1.40E-28 ID:SGTC_330|Compound:1488-0319|FD-Score:3.36|P-value:1.51E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.72|P-value:1.74E-7 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.37|P-value:1.40E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.87|P-value:7.34E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:2.88|P-value:9.70E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.45|P-value:1.03E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.70|P-value:3.22E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.91|P-value:8.48E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.83|P-value:9.73E-8 ID:SGTC_756|Compound:0508-1999|FD-Score:2.96|P-value:7.35E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.71|P-value:3.32E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.35|P-value:1.48E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.43|P-value:9.07E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.17|P-value:3.47E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-6.27|P-value:6.89E-12 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.99|P-value:3.71E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.88|P-value:9.28E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.17|P-value:3.50E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.30|P-value:1.85E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.14|P-value:3.52E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.33|P-value:4.44E-12 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.08|P-value:4.55E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.15|P-value:3.51E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.91|P-value:8.86E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.18|P-value:3.07E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.21|P-value:2.73E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.17|P-value:3.62E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.07|P-value:4.71E-4 ID:SGTC_1563|Compound:conessine|FD-Score:5.03|P-value:3.11E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.22|P-value:2.61E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.14|P-value:3.73E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.20|P-value:2.84E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.37|P-value:1.41E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.46|P-value:9.38E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-4.70|P-value:1.97E-7 ID:SGTC_1634|Compound:st006576|FD-Score:3.47|P-value:9.52E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-4.47|P-value:7.31E-7 ID:SGTC_1914|Compound:st062367|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.18|P-value:3.34E-6 ID:SGTC_2105|Compound:5350118|FD-Score:-3.40|P-value:1.24E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.08|P-value:4.53E-4 ID:SGTC_2192|Compound:5915882|FD-Score:-3.13|P-value:3.67E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.12|P-value:3.81E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.21|P-value:2.76E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.27|P-value:2.07E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-5.35|P-value:4.01E-9 ID:SGTC_2401|Compound:5128683|FD-Score:3.79|P-value:2.27E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.06|P-value:4.91E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.13|P-value:3.87E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.05|P-value:5.11E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.51|P-value:8.09E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.78|P-value:2.25E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-8.21|P-value:4.36E-19 ID:SGTC_2976|Compound:9009005|FD-Score:3.54|P-value:6.94E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-4.21|P-value:2.86E-6 ID:SGTC_2996|Compound:9066192|FD-Score:-3.02|P-value:5.68E-4 ID:SGTC_3023|Compound:9089636|FD-Score:2.92|P-value:8.53E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.91|P-value:1.22E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.73|P-value:2.94E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.32|P-value:1.73E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:2.88|P-value:9.82E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-4.81|P-value:1.10E-7 ID:SGTC_3066|Compound:9117245|FD-Score:-3.71|P-value:3.12E-5 ID:SGTC_3070|Compound:9117005|FD-Score:4.29|P-value:1.98E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-3.25|P-value:2.30E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.34|P-value:1.51E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.51|P-value:7.60E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.21|P-value:2.68E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-2.94|P-value:7.55E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-2.89|P-value:9.18E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.87|P-value:7.99E-8 ID:SGTC_3275|Compound:9138069|FD-Score:-3.18|P-value:2.99E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.50|P-value:8.26E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.32|P-value:1.67E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-10.20|P-value:1.40E-28 ID:SGTC_330|Compound:1488-0319|FD-Score:3.36|P-value:1.51E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.72|P-value:1.74E-7 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.37|P-value:1.40E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.87|P-value:7.34E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:2.88|P-value:9.70E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.45|P-value:1.03E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.70|P-value:3.22E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.91|P-value:8.48E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.83|P-value:9.73E-8 ID:SGTC_756|Compound:0508-1999|FD-Score:2.96|P-value:7.35E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.71|P-value:3.32E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.35|P-value:1.48E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.43|P-value:9.07E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.17|P-value:3.47E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-6.27|P-value:6.89E-12 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.99|P-value:3.71E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.88|P-value:9.28E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.17|P-value:3.50E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.30|P-value:1.85E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.14|P-value:3.52E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.33|P-value:4.44E-12 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.08|P-value:4.55E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.15|P-value:3.51E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.91|P-value:8.86E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.18|P-value:3.07E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.21|P-value:2.73E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.17|P-value:3.62E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.07|P-value:4.71E-4 ID:SGTC_1563|Compound:conessine|FD-Score:5.03|P-value:3.11E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.22|P-value:2.61E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.14|P-value:3.73E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.20|P-value:2.84E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.37|P-value:1.41E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.46|P-value:9.38E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-4.70|P-value:1.97E-7 ID:SGTC_1634|Compound:st006576|FD-Score:3.47|P-value:9.52E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-4.47|P-value:7.31E-7 ID:SGTC_1914|Compound:st062367|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.18|P-value:3.34E-6 ID:SGTC_2105|Compound:5350118|FD-Score:-3.40|P-value:1.24E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.08|P-value:4.53E-4 ID:SGTC_2192|Compound:5915882|FD-Score:-3.13|P-value:3.67E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.12|P-value:3.81E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.21|P-value:2.76E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.27|P-value:2.07E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-5.35|P-value:4.01E-9 ID:SGTC_2401|Compound:5128683|FD-Score:3.79|P-value:2.27E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.06|P-value:4.91E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.13|P-value:3.87E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.05|P-value:5.11E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.51|P-value:8.09E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.78|P-value:2.25E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-8.21|P-value:4.36E-19 ID:SGTC_2976|Compound:9009005|FD-Score:3.54|P-value:6.94E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-4.21|P-value:2.86E-6 ID:SGTC_2996|Compound:9066192|FD-Score:-3.02|P-value:5.68E-4 ID:SGTC_3023|Compound:9089636|FD-Score:2.92|P-value:8.53E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.91|P-value:1.22E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.73|P-value:2.94E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.32|P-value:1.73E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:2.88|P-value:9.82E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-4.81|P-value:1.10E-7 ID:SGTC_3066|Compound:9117245|FD-Score:-3.71|P-value:3.12E-5 ID:SGTC_3070|Compound:9117005|FD-Score:4.29|P-value:1.98E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-3.25|P-value:2.30E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.34|P-value:1.51E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.51|P-value:7.60E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.21|P-value:2.68E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-2.94|P-value:7.55E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-2.89|P-value:9.18E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.87|P-value:7.99E-8 ID:SGTC_3275|Compound:9138069|FD-Score:-3.18|P-value:2.99E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.50|P-value:8.26E-5

Top fitness defect scores for YDL060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1563 conessine 5.03 56.1 µM 3.11E-8 1 2.46E-7 1.12
2 SGTC_3274 9138298 4.87 49.5 µM 7.99E-8 3 5.57E-7 0.81
3 SGTC_3077 9117319 4.34 49.5 µM 1.51E-6 6 7.14E-6 0.38
4 SGTC_1055 3448-0672 4.30 86.0 µM 1.85E-6 9 8.52E-6 0.23
5 SGTC_3070 9117005 4.29 49.5 µM 1.98E-6 2 9.04E-6 0.18
6 SGTC_1330 1469-0054 4.17 61.8 µM 3.62E-6 iron homeostasis 5 1.52E-5 0.32
7 SGTC_2401 5128683 3.79 200.0 µM 2.27E-5 10 7.50E-5 0.13
8 SGTC_3048 9093155 3.73 49.5 µM 2.94E-5 1 9.40E-5 0.29
9 SGTC_757 1066-0008 3.71 322.0 µM 3.32E-5 Golgi 3 1.05E-4 0.04
10 SGTC_2976 9009005 3.54 19.5 µM 6.94E-5 10 1.98E-4 0.22
11 SGTC_2815 7968870 3.51 71.4 µM 8.09E-5 9 2.27E-4 0.15
12 SGTC_3298 9116858 3.50 71.4 µM 8.26E-5 7 2.31E-4 0.07
13 SGTC_1634 st006576 3.47 41.0 µM 9.52E-5 TSC3-RPN4 13 2.61E-4 0.28
14 SGTC_430 0958-0115 3.45 16.4 µM 1.03E-4 14 2.80E-4 0.03
15 SGTC_3042 9091578 3.42 49.5 µM 1.15E-4 ERG2 1 3.09E-4 0.20
16 SGTC_330 1488-0319 3.36 80.1 µM 1.51E-4 RPP1 & pyrimidine depletion 11 3.91E-4 0.07
17 SGTC_3125 9127534 3.29 49.5 µM 2.01E-4 9 5.01E-4 0.30
18 SGTC_1327 1436-0082 3.21 2.2 µM 2.73E-4 18 6.54E-4 0.05
19 SGTC_2353 9059630 3.21 146.7 µM 2.76E-4 3 6.59E-4 0.03
20 SGTC_1572 epiandrosterone 3.20 68.9 µM 2.84E-4 6 6.77E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.272 4.75E-58 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.247 8.83E-48 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.238 2.03E-44 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.237 5.13E-44 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.200 1.98E-31 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.192 4.05E-29 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.180 9.35E-26 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.176 1.08E-24 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.174 3.23E-24 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.173 4.81E-24 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.172 1.03E-23 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.170 3.49E-23 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.167 2.14E-22 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.161 7.97E-21 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.160 1.07E-20 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome