YDL062W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL062W / YDL062W

Click on Significant Values for Screen Details ID:SGTC_153|Compound:4077-0274|FD-Score:-3.76|P-value:9.08E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.58|P-value:1.85E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.45|P-value:5.48E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.60|P-value:1.87E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.01|P-value:3.73E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.24|P-value:6.93E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.28|P-value:5.46E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.31|P-value:5.32E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.59|P-value:1.77E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.15|P-value:9.27E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-4.17|P-value:1.64E-5 ID:SGTC_2308|Compound:7584454|FD-Score:4.76|P-value:1.24E-6 ID:SGTC_2333|Compound:9017922|FD-Score:-3.98|P-value:3.70E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.20|P-value:7.22E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.20|P-value:7.11E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.63|P-value:2.39E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.32|P-value:8.61E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.80|P-value:8.76E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.66|P-value:2.03E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.08|P-value:2.78E-5 ID:SGTC_2819|Compound:7996655|FD-Score:3.26|P-value:6.34E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.29|P-value:1.12E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.17|P-value:8.80E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.55|P-value:2.06E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.46|P-value:3.16E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-4.02|P-value:3.09E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.31|P-value:5.38E-4 ID:SGTC_3151|Compound:9099821|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.66|P-value:1.74E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.26|P-value:6.48E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-4.77|P-value:1.04E-6 ID:SGTC_3291|Compound:9121177|FD-Score:-3.53|P-value:2.23E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-4.17|P-value:1.68E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.76|P-value:9.08E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.58|P-value:1.85E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.45|P-value:5.48E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.60|P-value:1.87E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.01|P-value:3.73E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.24|P-value:6.93E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.28|P-value:5.46E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.31|P-value:5.32E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.59|P-value:1.77E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.15|P-value:9.27E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-4.17|P-value:1.64E-5 ID:SGTC_2308|Compound:7584454|FD-Score:4.76|P-value:1.24E-6 ID:SGTC_2333|Compound:9017922|FD-Score:-3.98|P-value:3.70E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.20|P-value:7.22E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.20|P-value:7.11E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.63|P-value:2.39E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.32|P-value:8.61E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.80|P-value:8.76E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.66|P-value:2.03E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.08|P-value:2.78E-5 ID:SGTC_2819|Compound:7996655|FD-Score:3.26|P-value:6.34E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.29|P-value:1.12E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.17|P-value:8.80E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.55|P-value:2.06E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.46|P-value:3.16E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-4.02|P-value:3.09E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.31|P-value:5.38E-4 ID:SGTC_3151|Compound:9099821|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.66|P-value:1.74E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.26|P-value:6.48E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-4.77|P-value:1.04E-6 ID:SGTC_3291|Compound:9121177|FD-Score:-3.53|P-value:2.23E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-4.17|P-value:1.68E-5

Top fitness defect scores for YDL062W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2308 7584454 4.76 197.6 µM 1.24E-6 10 9.60E-7
2 SGTC_2688 kanamycin b 4.66 96.7 µM 2.03E-6 calcium & mitochondrial duress 277 1.59E-6
3 SGTC_2617 dihydrotanshinone i 4.63 20.8 µM 2.39E-6 copper-dependent oxidative stress 17 1.87E-6
4 SGTC_680 0417-1641 4.45 114.0 µM 5.48E-6 RPP1 & pyrimidine depletion 6 4.36E-6
5 SGTC_2917 7979103 4.29 53.8 µM 1.12E-5 22 9.07E-6
6 SGTC_3151 9099821 4.25 49.5 µM 1.33E-5 10 1.08E-5
7 SGTC_1391 3442-0225 4.24 151.0 µM 1.37E-5 9 1.11E-5
8 SGTC_2809 7964133 4.08 13.0 µM 2.78E-5 60S ribosome export 35 2.28E-5
9 SGTC_978 1416-0512 4.01 87.4 µM 3.73E-5 redox potentiating 28 3.08E-5
10 SGTC_2664 lyso-paf C-16 3.80 73.5 µM 8.76E-5 16 7.35E-5
11 SGTC_2556 citropten 3.67 84.6 µM 1.46E-4 32 1.23E-4
12 SGTC_475 α-linolenic acid 3.66 10.0 µM 1.52E-4 excess fatty acid 23 1.28E-4
13 SGTC_3282 9108498 3.62 15.5 µM 1.71E-4 37 1.45E-4
14 SGTC_2702 st077768 3.61 96.8 µM 1.83E-4 21 1.55E-4
15 SGTC_766 1391-0721 3.60 126.0 µM 1.87E-4 23 1.59E-4
16 SGTC_2934 9036370 3.46 36.9 µM 3.16E-4 49 2.71E-4
17 SGTC_529 4076-0302 3.41 30.3 µM 3.76E-4 mitochondrial processes 29 3.24E-4
18 SGTC_558 k064-0027 3.38 21.3 µM 4.27E-4 DNA damage response 49 3.69E-4
19 SGTC_1328 1441-0025 3.31 69.2 µM 5.32E-4 20 4.61E-4
20 SGTC_3144 9087057 3.31 49.5 µM 5.38E-4 33 4.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.72E-10 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.107 5.98E-10 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.107 6.08E-10 YDR415C_p YDR415C_p hom Putative aminopeptidase
0.102 3.25E-9 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.101 5.46E-9 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
0.097 2.07E-8 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.096 3.01E-8 YPR044C_d OPI11_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
0.089 2.44E-7 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.088 3.44E-7 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.087 4.62E-7 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.085 8.18E-7 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.085 8.21E-7 YLR180W SAM1 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication
0.085 8.91E-7 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.085 8.70E-7 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.084 1.23E-6 YMR194W RPL36A hom Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication