YDL064W / UBC9

SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL064W / UBC9

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:2.91|P-value:6.92E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.51|P-value:5.66E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.35|P-value:1.95E-9 ID:SGTC_332|Compound:4112-0506|FD-Score:-2.85|P-value:8.66E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.22|P-value:1.74E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:4.02|P-value:4.93E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:2.90|P-value:7.19E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.75|P-value:1.81E-5 ID:SGTC_401|Compound:neomycin|FD-Score:-3.32|P-value:1.30E-4 ID:SGTC_490|Compound:phenamil|FD-Score:3.09|P-value:3.39E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.25|P-value:1.44E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:2.92|P-value:6.66E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.43|P-value:5.43E-7 ID:SGTC_693|Compound:4161-2696|FD-Score:3.90|P-value:8.97E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:4.30|P-value:1.13E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:2.91|P-value:6.84E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.58|P-value:4.04E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.62|P-value:3.12E-10 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.90|P-value:7.02E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.04|P-value:4.19E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.40|P-value:9.19E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.48|P-value:4.10E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.96|P-value:6.72E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.00|P-value:4.80E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.81|P-value:1.40E-5 ID:SGTC_1558|Compound:st069300|FD-Score:2.92|P-value:6.73E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.98|P-value:5.15E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.56|P-value:4.61E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.15|P-value:2.66E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.84|P-value:1.21E-5 ID:SGTC_1705|Compound:st027868|FD-Score:2.86|P-value:8.21E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.95|P-value:5.77E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-2.95|P-value:5.95E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.23|P-value:1.61E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.61|P-value:3.63E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.83|P-value:5.53E-8 ID:SGTC_1895|Compound:st058434|FD-Score:2.88|P-value:7.60E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.23|P-value:1.89E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.32|P-value:1.27E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.14|P-value:2.68E-6 ID:SGTC_2072|Compound:5231554|FD-Score:-4.06|P-value:3.93E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:2.92|P-value:6.54E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.41|P-value:8.74E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.40|P-value:9.29E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.75|P-value:8.75E-8 ID:SGTC_2315|Compound:7733312|FD-Score:6.87|P-value:2.03E-14 ID:SGTC_2339|Compound:9000433|FD-Score:-3.08|P-value:3.56E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.08|P-value:3.57E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.81|P-value:9.94E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.10|P-value:3.25E-6 ID:SGTC_2921|Compound:7974240|FD-Score:2.86|P-value:8.42E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.96|P-value:5.59E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.15|P-value:2.50E-6 ID:SGTC_2989|Compound:9073649|FD-Score:-3.05|P-value:3.93E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.68|P-value:2.55E-5 ID:SGTC_3136|Compound:9095672|FD-Score:2.99|P-value:5.11E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.63|P-value:3.31E-5 ID:SGTC_3179|Compound:9107801|FD-Score:-3.04|P-value:4.18E-4 ID:SGTC_3244|Compound:9134489|FD-Score:2.87|P-value:7.99E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.40|P-value:9.17E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:2.91|P-value:6.92E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.51|P-value:5.66E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.35|P-value:1.95E-9 ID:SGTC_332|Compound:4112-0506|FD-Score:-2.85|P-value:8.66E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.22|P-value:1.74E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:4.02|P-value:4.93E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:2.90|P-value:7.19E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.75|P-value:1.81E-5 ID:SGTC_401|Compound:neomycin|FD-Score:-3.32|P-value:1.30E-4 ID:SGTC_490|Compound:phenamil|FD-Score:3.09|P-value:3.39E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.25|P-value:1.44E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:2.92|P-value:6.66E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.43|P-value:5.43E-7 ID:SGTC_693|Compound:4161-2696|FD-Score:3.90|P-value:8.97E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:4.30|P-value:1.13E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:2.91|P-value:6.84E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.58|P-value:4.04E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.62|P-value:3.12E-10 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.90|P-value:7.02E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.04|P-value:4.19E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.40|P-value:9.19E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.48|P-value:4.10E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.96|P-value:6.72E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.00|P-value:4.80E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.81|P-value:1.40E-5 ID:SGTC_1558|Compound:st069300|FD-Score:2.92|P-value:6.73E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.98|P-value:5.15E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.56|P-value:4.61E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.15|P-value:2.66E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.84|P-value:1.21E-5 ID:SGTC_1705|Compound:st027868|FD-Score:2.86|P-value:8.21E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.95|P-value:5.77E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-2.95|P-value:5.95E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.23|P-value:1.61E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.61|P-value:3.63E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.83|P-value:5.53E-8 ID:SGTC_1895|Compound:st058434|FD-Score:2.88|P-value:7.60E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.23|P-value:1.89E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.32|P-value:1.27E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.14|P-value:2.68E-6 ID:SGTC_2072|Compound:5231554|FD-Score:-4.06|P-value:3.93E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:2.92|P-value:6.54E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.41|P-value:8.74E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.40|P-value:9.29E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.75|P-value:8.75E-8 ID:SGTC_2315|Compound:7733312|FD-Score:6.87|P-value:2.03E-14 ID:SGTC_2339|Compound:9000433|FD-Score:-3.08|P-value:3.56E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.08|P-value:3.57E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.81|P-value:9.94E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.10|P-value:3.25E-6 ID:SGTC_2921|Compound:7974240|FD-Score:2.86|P-value:8.42E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.96|P-value:5.59E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.15|P-value:2.50E-6 ID:SGTC_2989|Compound:9073649|FD-Score:-3.05|P-value:3.93E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.68|P-value:2.55E-5 ID:SGTC_3136|Compound:9095672|FD-Score:2.99|P-value:5.11E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.63|P-value:3.31E-5 ID:SGTC_3179|Compound:9107801|FD-Score:-3.04|P-value:4.18E-4 ID:SGTC_3244|Compound:9134489|FD-Score:2.87|P-value:7.99E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.40|P-value:9.17E-5

Top fitness defect scores for YDL064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2315 7733312 6.87 200.0 µM 2.03E-14 2 3.17E-12 1.22
2 SGTC_996 3970-0799 5.62 1.8 µM 3.12E-10 10 9.41E-9 0.32
3 SGTC_273 hydroxyurea 5.35 18.1 mM 1.95E-9 heme biosynthesis & mitochondrial translocase 8 4.31E-8 0.08
4 SGTC_1887 st057648 4.83 70.8 µM 5.53E-8 2 6.96E-7 0.39
5 SGTC_2314 7727897 4.75 200.0 µM 8.75E-8 2 1.02E-6 0.93
6 SGTC_1333 1482-0047 4.48 286.0 µM 4.10E-7 4 3.68E-6 0.35
7 SGTC_669 0108-0021 4.43 26.2 µM 5.43E-7 fatty acid desaturase (OLE1) 9 4.65E-6 0.05
8 SGTC_711 k292-0785 4.30 179.0 µM 1.13E-6 DNA intercalators 5 8.57E-6 0.50
9 SGTC_491 tetrandrine 4.25 80.3 µM 1.44E-6 3 1.05E-5 0.25
10 SGTC_1756 st041558 4.23 35.5 µM 1.61E-6 1 1.15E-5 0.41
11 SGTC_2988 9073640 4.15 71.4 µM 2.50E-6 11 1.66E-5 0.11
12 SGTC_2056 5235370 4.14 200.0 µM 2.68E-6 6 1.76E-5 0.37
13 SGTC_2765 myclobutanil 4.10 7.7 µM 3.25E-6 azole & statin 7 2.07E-5 0.15
14 SGTC_2344 7990960 4.08 77.0 µM 3.57E-6 38 2.23E-5 0.04
15 SGTC_373 0844-0104 4.02 25.9 µM 4.93E-6 ERAD & cell cycle 11 2.92E-5 0.19
16 SGTC_693 4161-2696 3.90 114.0 µM 8.97E-6 4 4.82E-5 0.11
17 SGTC_1699 st031318 3.84 29.1 µM 1.21E-5 1 6.19E-5 0.38
18 SGTC_1378 2093-0007 3.81 380.0 nM 1.40E-5 7 7.00E-5 0.10
19 SGTC_3073 9114972 3.68 49.5 µM 2.55E-5 60S ribosome export 7 1.15E-4 0.21
20 SGTC_3142 9086498 3.63 49.5 µM 3.31E-5 iron homeostasis 50 1.43E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 6.30E-36 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.191 5.72E-29 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.181 4.12E-26 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.159 2.50E-20 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.155 2.07E-19 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.144 5.94E-17 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.144 5.96E-17 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.134 7.75E-15 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.133 1.33E-14 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.132 1.98E-14 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.129 5.46E-14 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.127 1.38E-13 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.119 3.80E-12 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.119 5.16E-12 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.117 1.04E-11 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C