YDL065C / PEX19

Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL065C / PEX19

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.13|P-value:4.35E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.58|P-value:3.43E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.84|P-value:2.18E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:1.32E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.33|P-value:8.09E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.55|P-value:3.19E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.74|P-value:2.70E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.24|P-value:9.05E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.44|P-value:4.61E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.41|P-value:6.17E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.85|P-value:1.05E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.46|P-value:4.34E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.55|P-value:3.18E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.66|P-value:2.19E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:5.66|P-value:2.85E-8 ID:SGTC_894|Compound:0960-0238|FD-Score:3.92|P-value:8.37E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:1.38E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.86|P-value:1.02E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.47|P-value:4.96E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.58|P-value:4.29E-8 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.33|P-value:6.67E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.69|P-value:3.38E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.67|P-value:3.70E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.41|P-value:1.40E-5 ID:SGTC_1845|Compound:st056753|FD-Score:5.07|P-value:5.56E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:3.46|P-value:4.38E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.34|P-value:7.67E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.50|P-value:4.53E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.77|P-value:1.45E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.49|P-value:3.87E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.28|P-value:9.39E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.22|P-value:9.77E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.84|P-value:1.68E-6 ID:SGTC_2094|Compound:5332512|FD-Score:4.42|P-value:1.08E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.15|P-value:3.32E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.46|P-value:4.34E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.91|P-value:8.43E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.35|P-value:1.48E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.41|P-value:5.11E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.00|P-value:7.47E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.23|P-value:9.40E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.40|P-value:6.44E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.55|P-value:3.88E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.50|P-value:6.45E-8 ID:SGTC_2883|Compound:9059145|FD-Score:-3.51|P-value:4.40E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.68|P-value:3.52E-6 ID:SGTC_3293|Compound:9120939|FD-Score:3.42|P-value:4.97E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.27|P-value:9.69E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.90|P-value:1.06E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.13|P-value:4.35E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.58|P-value:3.43E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.84|P-value:2.18E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:1.32E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.33|P-value:8.09E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.55|P-value:3.19E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.74|P-value:2.70E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.24|P-value:9.05E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.44|P-value:4.61E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.41|P-value:6.17E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.85|P-value:1.05E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.46|P-value:4.34E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.55|P-value:3.18E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.66|P-value:2.19E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:5.66|P-value:2.85E-8 ID:SGTC_894|Compound:0960-0238|FD-Score:3.92|P-value:8.37E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:1.38E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.86|P-value:1.02E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.47|P-value:4.96E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.58|P-value:4.29E-8 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.33|P-value:6.67E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.69|P-value:3.38E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.67|P-value:3.70E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.41|P-value:1.40E-5 ID:SGTC_1845|Compound:st056753|FD-Score:5.07|P-value:5.56E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:3.46|P-value:4.38E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.34|P-value:7.67E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.50|P-value:4.53E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.77|P-value:1.45E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.49|P-value:3.87E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.28|P-value:9.39E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.22|P-value:9.77E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.84|P-value:1.68E-6 ID:SGTC_2094|Compound:5332512|FD-Score:4.42|P-value:1.08E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.15|P-value:3.32E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.46|P-value:4.34E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.91|P-value:8.43E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.35|P-value:1.48E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.41|P-value:5.11E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.00|P-value:7.47E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.23|P-value:9.40E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.40|P-value:6.44E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.55|P-value:3.88E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.50|P-value:6.45E-8 ID:SGTC_2883|Compound:9059145|FD-Score:-3.51|P-value:4.40E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.68|P-value:3.52E-6 ID:SGTC_3293|Compound:9120939|FD-Score:3.42|P-value:4.97E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.27|P-value:9.69E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.90|P-value:1.06E-4

Top fitness defect scores for YDL065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_807 1315-0151 5.66 48.0 µM 2.85E-8 7 7.66E-9
2 SGTC_1255 0566-0045 5.58 221.0 µM 4.29E-8 excess fatty acid 7 1.20E-8
3 SGTC_2858 9025781 5.50 9.0 µM 6.45E-8 sphingolipid biosynthesis & PDR1 55 1.86E-8
4 SGTC_8 0354-0001 5.13 70.0 µM 4.35E-7 39 1.49E-7
5 SGTC_1845 st056753 5.07 3.0 µM 5.56E-7 TSC3-RPN4 19 1.94E-7
6 SGTC_2087 5276107 4.84 200.0 µM 1.68E-6 6 6.49E-7
7 SGTC_236 1509-0011 4.74 5.3 µM 2.70E-6 340 1.08E-6
8 SGTC_1592 4',5'-dihydroxyflavone 4.69 8.8 µM 3.38E-6 60S ribosome export 4 1.38E-6
9 SGTC_3189 9110682 4.68 49.5 µM 3.52E-6 21 1.44E-6
10 SGTC_1635 st007035 4.67 42.4 µM 3.70E-6 177 1.53E-6
11 SGTC_2094 5332512 4.42 191.7 µM 1.08E-5 13 4.88E-6
12 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.35 63.6 µM 1.48E-5 29 6.90E-6
13 SGTC_2126 5251174 4.15 33.9 µM 3.32E-5 25 1.65E-5
14 SGTC_894 0960-0238 3.92 55.9 µM 8.37E-5 12 4.52E-5
15 SGTC_2434 5670830 3.91 169.9 µM 8.43E-5 27 4.55E-5
16 SGTC_1236 0330-0013 3.86 258.0 µM 1.02E-4 9 5.60E-5
17 SGTC_584 0986-0246 3.85 15.4 µM 1.05E-4 heme requiring 14 5.80E-5
18 SGTC_1164 k060-0068 3.78 93.7 µM 1.38E-4 31 7.76E-5
19 SGTC_1978 st071761 3.77 42.0 µM 1.45E-4 TSC3-RPN4 17 8.20E-5
20 SGTC_46 0329-0187a 3.67 2.2 µM 2.06E-4 85 1.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 3.47E-27 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.176 8.93E-25 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.174 4.54E-24 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.171 2.57E-23 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.170 3.39E-23 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.170 4.41E-23 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.168 1.60E-22 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.168 1.72E-22 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.166 5.02E-22 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.155 1.67E-19 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.152 6.65E-19 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.152 9.17E-19 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.150 3.07E-18 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.146 1.50E-17 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.146 1.63E-17 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs