YDL066W / IDP1

Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL066W / IDP1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:6.33|P-value:5.95E-8 ID:SGTC_55|Compound:0767-0285|FD-Score:4.02|P-value:4.85E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:16.10|P-value:3.38E-43 ID:SGTC_115|Compound:0527-0192|FD-Score:5.07|P-value:1.31E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:10.20|P-value:2.56E-18 ID:SGTC_138|Compound:0850-0259|FD-Score:11.20|P-value:1.49E-21 ID:SGTC_305|Compound:1682-2595|FD-Score:3.87|P-value:7.71E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.01|P-value:2.70E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:6.94|P-value:2.95E-9 ID:SGTC_360|Compound:0957-0399|FD-Score:6.01|P-value:2.64E-7 ID:SGTC_397|Compound:arbidol|FD-Score:3.80|P-value:9.35E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.97|P-value:1.91E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:9.42|P-value:9.26E-16 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.78|P-value:3.09E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.88|P-value:2.69E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.73|P-value:9.16E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:3.90|P-value:7.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.37|P-value:5.15E-8 ID:SGTC_709|Compound:3807-1509|FD-Score:4.53|P-value:9.18E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:4.80|P-value:3.60E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.93|P-value:6.31E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.80|P-value:9.48E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:10.20|P-value:2.49E-18 ID:SGTC_928|Compound:2764-0428|FD-Score:4.97|P-value:1.88E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:18.70|P-value:1.74E-57 ID:SGTC_995|Compound:3931-2021|FD-Score:4.36|P-value:1.62E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.62|P-value:6.75E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.70|P-value:9.88E-9 ID:SGTC_1627|Compound:st003713|FD-Score:4.64|P-value:6.26E-5 ID:SGTC_1666|Compound:st014829|FD-Score:4.08|P-value:3.99E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.31|P-value:1.93E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.87|P-value:7.63E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.62|P-value:1.42E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.73|P-value:4.55E-5 ID:SGTC_1762|Compound:st045503|FD-Score:4.02|P-value:4.92E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.29|P-value:5.45E-6 ID:SGTC_1826|Compound:st055655|FD-Score:5.57|P-value:1.81E-6 ID:SGTC_1843|Compound:st055809|FD-Score:4.91|P-value:2.42E-5 ID:SGTC_1857|Compound:st056007|FD-Score:4.18|P-value:2.94E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.98|P-value:5.52E-4 ID:SGTC_2172|Compound:5754775|FD-Score:4.75|P-value:4.23E-5 ID:SGTC_2339|Compound:9000433|FD-Score:4.30|P-value:1.99E-4 ID:SGTC_2367|Compound:9070478|FD-Score:5.48|P-value:2.58E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.91|P-value:6.70E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:8.22|P-value:2.24E-12 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.60|P-value:1.19E-19 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.79|P-value:6.92E-7 ID:SGTC_2671|Compound:danthron|FD-Score:4.93|P-value:2.19E-5 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.39|P-value:1.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.87|P-value:7.72E-4 ID:SGTC_2800|Compound:7887935|FD-Score:10.00|P-value:1.21E-17 ID:SGTC_2818|Compound:7996756|FD-Score:4.40|P-value:1.43E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.91|P-value:6.75E-4 ID:SGTC_2835|Compound:9006588|FD-Score:6.49|P-value:2.79E-8 ID:SGTC_2912|Compound:7964298|FD-Score:4.62|P-value:6.69E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.37|P-value:1.58E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-4.27|P-value:5.95E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.51|P-value:7.04E-4 ID:SGTC_3046|Compound:9092212|FD-Score:5.57|P-value:1.76E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.63|P-value:2.03E-16 ID:SGTC_3074|Compound:9116018|FD-Score:4.24|P-value:2.45E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.91|P-value:2.39E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.17|P-value:3.02E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.92|P-value:6.63E-4 ID:SGTC_3266|Compound:9136860|FD-Score:9.51|P-value:4.73E-16 ID:SGTC_3285|Compound:9112818|FD-Score:8.71|P-value:1.05E-13 ID:SGTC_3311|Compound:9131146|FD-Score:17.30|P-value:1.92E-49 ID:SGTC_3321|Compound:9137793|FD-Score:13.90|P-value:1.88E-32 ID:SGTC_3322|Compound:9139058|FD-Score:4.07|P-value:4.16E-4 ID:SGTC_3331|Compound:9141060|FD-Score:8.40|P-value:7.27E-13 ID:SGTC_3350|Compound:9150499|FD-Score:5.22|P-value:7.35E-6 ID:SGTC_3351|Compound:9150312|FD-Score:4.04|P-value:4.57E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.86|P-value:7.75E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:6.33|P-value:5.95E-8 ID:SGTC_55|Compound:0767-0285|FD-Score:4.02|P-value:4.85E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:16.10|P-value:3.38E-43 ID:SGTC_115|Compound:0527-0192|FD-Score:5.07|P-value:1.31E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:10.20|P-value:2.56E-18 ID:SGTC_138|Compound:0850-0259|FD-Score:11.20|P-value:1.49E-21 ID:SGTC_305|Compound:1682-2595|FD-Score:3.87|P-value:7.71E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.01|P-value:2.70E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:6.94|P-value:2.95E-9 ID:SGTC_360|Compound:0957-0399|FD-Score:6.01|P-value:2.64E-7 ID:SGTC_397|Compound:arbidol|FD-Score:3.80|P-value:9.35E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.97|P-value:1.91E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:9.42|P-value:9.26E-16 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.78|P-value:3.09E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.88|P-value:2.69E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.73|P-value:9.16E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:3.90|P-value:7.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.37|P-value:5.15E-8 ID:SGTC_709|Compound:3807-1509|FD-Score:4.53|P-value:9.18E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:4.80|P-value:3.60E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.93|P-value:6.31E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.80|P-value:9.48E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:10.20|P-value:2.49E-18 ID:SGTC_928|Compound:2764-0428|FD-Score:4.97|P-value:1.88E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:18.70|P-value:1.74E-57 ID:SGTC_995|Compound:3931-2021|FD-Score:4.36|P-value:1.62E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.62|P-value:6.75E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.70|P-value:9.88E-9 ID:SGTC_1627|Compound:st003713|FD-Score:4.64|P-value:6.26E-5 ID:SGTC_1666|Compound:st014829|FD-Score:4.08|P-value:3.99E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.31|P-value:1.93E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.87|P-value:7.63E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.62|P-value:1.42E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.73|P-value:4.55E-5 ID:SGTC_1762|Compound:st045503|FD-Score:4.02|P-value:4.92E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.29|P-value:5.45E-6 ID:SGTC_1826|Compound:st055655|FD-Score:5.57|P-value:1.81E-6 ID:SGTC_1843|Compound:st055809|FD-Score:4.91|P-value:2.42E-5 ID:SGTC_1857|Compound:st056007|FD-Score:4.18|P-value:2.94E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.98|P-value:5.52E-4 ID:SGTC_2172|Compound:5754775|FD-Score:4.75|P-value:4.23E-5 ID:SGTC_2339|Compound:9000433|FD-Score:4.30|P-value:1.99E-4 ID:SGTC_2367|Compound:9070478|FD-Score:5.48|P-value:2.58E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.91|P-value:6.70E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:8.22|P-value:2.24E-12 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.60|P-value:1.19E-19 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.79|P-value:6.92E-7 ID:SGTC_2671|Compound:danthron|FD-Score:4.93|P-value:2.19E-5 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.39|P-value:1.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.87|P-value:7.72E-4 ID:SGTC_2800|Compound:7887935|FD-Score:10.00|P-value:1.21E-17 ID:SGTC_2818|Compound:7996756|FD-Score:4.40|P-value:1.43E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.91|P-value:6.75E-4 ID:SGTC_2835|Compound:9006588|FD-Score:6.49|P-value:2.79E-8 ID:SGTC_2912|Compound:7964298|FD-Score:4.62|P-value:6.69E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.37|P-value:1.58E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-4.27|P-value:5.95E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.51|P-value:7.04E-4 ID:SGTC_3046|Compound:9092212|FD-Score:5.57|P-value:1.76E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.63|P-value:2.03E-16 ID:SGTC_3074|Compound:9116018|FD-Score:4.24|P-value:2.45E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.91|P-value:2.39E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.17|P-value:3.02E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.92|P-value:6.63E-4 ID:SGTC_3266|Compound:9136860|FD-Score:9.51|P-value:4.73E-16 ID:SGTC_3285|Compound:9112818|FD-Score:8.71|P-value:1.05E-13 ID:SGTC_3311|Compound:9131146|FD-Score:17.30|P-value:1.92E-49 ID:SGTC_3321|Compound:9137793|FD-Score:13.90|P-value:1.88E-32 ID:SGTC_3322|Compound:9139058|FD-Score:4.07|P-value:4.16E-4 ID:SGTC_3331|Compound:9141060|FD-Score:8.40|P-value:7.27E-13 ID:SGTC_3350|Compound:9150499|FD-Score:5.22|P-value:7.35E-6 ID:SGTC_3351|Compound:9150312|FD-Score:4.04|P-value:4.57E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.86|P-value:7.75E-4

Top fitness defect scores for YDL066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_951 1171-0579 18.70 82.7 µM 1.74E-57 cell wall 3 3.69E-78
2 SGTC_3311 9131146 17.30 2.9 µM 1.92E-49 cell wall 2 3.11E-67
3 SGTC_58 0957-0393 16.10 9.0 µM 3.38E-43 cell wall 24 9.59E-59
4 SGTC_3321 9137793 13.90 26.8 µM 1.88E-32 cell wall 5 4.01E-44
5 SGTC_138 0850-0259 11.20 40.9 µM 1.49E-21 cell wall 33 2.86E-29
6 SGTC_2651 1327-0036 10.60 5.0 µM 1.19E-19 20 1.14E-26
7 SGTC_863 0466-0191 10.20 129.0 µM 2.49E-18 cell wall 10 7.25E-25
8 SGTC_121 0557-0495 10.20 61.3 µM 2.56E-18 calcium & mitochondrial duress 5 7.53E-25
9 SGTC_2800 7887935 10.00 81.8 µM 1.21E-17 RPP1 & pyrimidine depletion 1 6.30E-24
10 SGTC_3063 1327-0034 9.63 4.0 µM 2.03E-16 8 2.96E-22
11 SGTC_3266 9136860 9.51 49.5 µM 4.73E-16 cell wall 8 9.42E-22
12 SGTC_514 4466-0038 9.42 2.6 nM 9.26E-16 cell wall 25 2.36E-21
13 SGTC_3285 9112818 8.71 20.9 µM 1.05E-13 cell wall 4 1.53E-18
14 SGTC_3331 9141060 8.40 2.0 µM 7.27E-13 cell wall 3 2.16E-17
15 SGTC_2584 androsterone 8.22 48.7 µM 2.24E-12 cell wall 26 1.01E-16
16 SGTC_354 2783-3500 6.94 4.9 µM 2.95E-9 cell wall 12 1.92E-12
17 SGTC_1597 7-benzyloxygramine 6.70 47.5 µM 9.88E-9 calcium & mitochondrial duress 41 1.01E-11
18 SGTC_2835 9006588 6.49 71.4 µM 2.79E-8 5 4.20E-11
19 SGTC_666 0272-0154 6.37 136.0 µM 5.15E-8 cell wall 18 9.75E-11
20 SGTC_54 0159-0055 6.33 9.0 µM 5.95E-8 ERG2 19 1.19E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.535 3.10E-248 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.490 1.59E-202 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.462 2.47E-177 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.452 8.73E-169 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.434 2.92E-154 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.429 1.50E-150 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.422 2.54E-145 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.422 3.91E-145 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.414 1.94E-139 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.413 1.80E-138 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.413 3.47E-138 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.411 4.67E-137 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.395 5.55E-126 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.385 3.56E-119 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.385 8.59E-119 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene