YDL067C / COX9

Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL067C / COX9

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-4.04|P-value:2.31E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.66|P-value:1.11E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.38|P-value:3.27E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.66|P-value:1.30E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-4.74|P-value:8.92E-7 ID:SGTC_34|Compound:0469-0683|FD-Score:6.29|P-value:1.51E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.01|P-value:3.09E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:4.59|P-value:2.20E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.29|P-value:5.16E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.16|P-value:8.14E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:7.36|P-value:8.85E-14 ID:SGTC_100|Compound:0086-0128|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:20.90|P-value:3.10E-98 ID:SGTC_149|Compound:3970-0822|FD-Score:4.20|P-value:1.37E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.14|P-value:8.73E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.00|P-value:2.74E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.62|P-value:1.91E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.12|P-value:9.17E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.60|P-value:3.56E-86 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.05|P-value:2.64E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.41|P-value:5.35E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.27|P-value:5.55E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:8.26|P-value:6.59E-17 ID:SGTC_386|Compound:1509-0011|FD-Score:21.30|P-value:2.45E-101 ID:SGTC_408|Compound:cantharidin|FD-Score:3.12|P-value:9.39E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.44|P-value:2.98E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.33|P-value:3.91E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.11|P-value:9.46E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:-4.52|P-value:2.58E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.15|P-value:1.68E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:6.55|P-value:2.81E-11 ID:SGTC_762|Compound:1165-0429|FD-Score:4.15|P-value:1.71E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-5.43|P-value:2.27E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:4.01|P-value:3.08E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.17|P-value:7.74E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.53|P-value:1.81E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.46|P-value:2.76E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.84|P-value:6.23E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.87|P-value:5.54E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:5.39|P-value:3.41E-8 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.33|P-value:4.42E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.21|P-value:6.84E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:5.03|P-value:2.43E-7 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.57|P-value:1.57E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.21|P-value:5.87E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.66|P-value:1.29E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.16|P-value:7.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:25.70|P-value:2.17E-146 ID:SGTC_1651|Compound:st011928|FD-Score:3.30|P-value:4.91E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.67|P-value:1.49E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.94|P-value:4.22E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.08|P-value:9.17E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.39|P-value:5.74E-6 ID:SGTC_2021|Compound:4019055|FD-Score:-3.30|P-value:4.29E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.76|P-value:7.98E-7 ID:SGTC_2106|Compound:5357045|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.50|P-value:3.42E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:6.93|P-value:2.04E-12 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.33|P-value:7.57E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.17|P-value:7.93E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.15|P-value:7.42E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.48|P-value:2.21E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.15|P-value:8.47E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.88|P-value:5.25E-5 ID:SGTC_2789|Compound:5281112|FD-Score:5.14|P-value:1.39E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-3.47|P-value:2.32E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.28|P-value:5.37E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.15|P-value:8.49E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.69|P-value:1.14E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.22|P-value:5.63E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.84|P-value:5.27E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.95|P-value:3.91E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.07|P-value:9.76E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.13|P-value:1.81E-5 ID:SGTC_3344|Compound:9148862|FD-Score:-3.32|P-value:3.98E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.27|P-value:5.53E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.22|P-value:6.67E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-4.04|P-value:2.31E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.66|P-value:1.11E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.38|P-value:3.27E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.66|P-value:1.30E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-4.74|P-value:8.92E-7 ID:SGTC_34|Compound:0469-0683|FD-Score:6.29|P-value:1.51E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.01|P-value:3.09E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:4.59|P-value:2.20E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.29|P-value:5.16E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.16|P-value:8.14E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:7.36|P-value:8.85E-14 ID:SGTC_100|Compound:0086-0128|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:20.90|P-value:3.10E-98 ID:SGTC_149|Compound:3970-0822|FD-Score:4.20|P-value:1.37E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.14|P-value:8.73E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.00|P-value:2.74E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.62|P-value:1.91E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.12|P-value:9.17E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.60|P-value:3.56E-86 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.05|P-value:2.64E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.41|P-value:5.35E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.27|P-value:5.55E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:8.26|P-value:6.59E-17 ID:SGTC_386|Compound:1509-0011|FD-Score:21.30|P-value:2.45E-101 ID:SGTC_408|Compound:cantharidin|FD-Score:3.12|P-value:9.39E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.44|P-value:2.98E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.33|P-value:3.91E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.11|P-value:9.46E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:-4.52|P-value:2.58E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.15|P-value:1.68E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:6.55|P-value:2.81E-11 ID:SGTC_762|Compound:1165-0429|FD-Score:4.15|P-value:1.71E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-5.43|P-value:2.27E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:4.01|P-value:3.08E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.17|P-value:7.74E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.53|P-value:1.81E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.46|P-value:2.76E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.84|P-value:6.23E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.87|P-value:5.54E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:5.39|P-value:3.41E-8 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.33|P-value:4.42E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.21|P-value:6.84E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:5.03|P-value:2.43E-7 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.57|P-value:1.57E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.21|P-value:5.87E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.66|P-value:1.29E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.16|P-value:7.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:25.70|P-value:2.17E-146 ID:SGTC_1651|Compound:st011928|FD-Score:3.30|P-value:4.91E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.67|P-value:1.49E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.94|P-value:4.22E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.08|P-value:9.17E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.39|P-value:5.74E-6 ID:SGTC_2021|Compound:4019055|FD-Score:-3.30|P-value:4.29E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.76|P-value:7.98E-7 ID:SGTC_2106|Compound:5357045|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.50|P-value:3.42E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:6.93|P-value:2.04E-12 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.33|P-value:7.57E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.17|P-value:7.93E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.15|P-value:7.42E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.48|P-value:2.21E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.15|P-value:8.47E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.88|P-value:5.25E-5 ID:SGTC_2789|Compound:5281112|FD-Score:5.14|P-value:1.39E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-3.47|P-value:2.32E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.28|P-value:5.37E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.15|P-value:8.49E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.69|P-value:1.14E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.22|P-value:5.63E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.84|P-value:5.27E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.95|P-value:3.91E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.07|P-value:9.76E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.13|P-value:1.81E-5 ID:SGTC_3344|Compound:9148862|FD-Score:-3.32|P-value:3.98E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.27|P-value:5.53E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.22|P-value:6.67E-4

Top fitness defect scores for YDL067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 25.70 42.4 µM 2.17E-146 13 1.70E-145
2 SGTC_386 1509-0011 21.30 3.1 µM 2.45E-101 4 9.41E-101
3 SGTC_134 0269-0018 20.90 6.9 µM 3.10E-98 6 1.14E-97
4 SGTC_236 1509-0011 19.60 5.3 µM 3.56E-86 57 1.08E-85
5 SGTC_335 4077-0256 8.26 27.6 µM 6.59E-17 1 7.32E-17
6 SGTC_87 0100-0052 7.36 35.5 µM 8.85E-14 15 9.46E-14
7 SGTC_2576 guaiol 6.93 23.1 µM 2.04E-12 4 2.14E-12
8 SGTC_761 k216-0224 6.55 480.0 µM 2.81E-11 3 2.93E-11
9 SGTC_34 0469-0683 6.29 81.8 µM 1.51E-10 SWF1 & branched chain AA biosynthesis 10 1.56E-10
10 SGTC_1437 4092-1038 5.39 11.6 µM 3.41E-8 5 3.44E-8
11 SGTC_2789 5281112 5.14 71.4 µM 1.39E-7 12 1.39E-7
12 SGTC_1472 k841-0093 5.03 193.0 µM 2.43E-7 5 2.43E-7
13 SGTC_1657 st012939 4.67 43.4 µM 1.49E-6 5 1.48E-6
14 SGTC_168 3970-0862 4.62 530.5 µM 1.91E-6 85 1.89E-6
15 SGTC_59 0330-0160 4.59 1.3 µM 2.20E-6 80 2.18E-6
16 SGTC_2500 5-alpha-androstan-3,17-dione 4.50 61.4 µM 3.42E-6 28 3.39E-6
17 SGTC_310 1273-0058 4.41 1.1 µM 5.35E-6 mitochondrial stress 216 5.29E-6
18 SGTC_1941 st076221 4.39 61.8 µM 5.74E-6 sphingolipid biosynthesis & PDR1 60 5.68E-6
19 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.33 15.3 µM 7.57E-6 23 7.47E-6
20 SGTC_149 3970-0822 4.20 46.1 µM 1.37E-5 tubulin folding & SWR complex 83 1.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.699 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.682 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.675 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.675 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.675 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.669 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.646 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.645 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.640 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.634 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.629 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.623 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.617 0 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.603 0 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.603 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes