YDL068W_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL068W / YDL068W

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.93|P-value:2.02E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.13|P-value:1.63E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:3.78|P-value:3.24E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:10.50|P-value:2.12E-21 ID:SGTC_149|Compound:3970-0822|FD-Score:4.47|P-value:2.85E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.51|P-value:7.88E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.46|P-value:8.88E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.28|P-value:5.69E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.37|P-value:4.08E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.76|P-value:3.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:23.00|P-value:1.58E-95 ID:SGTC_253|Compound:dyclonine|FD-Score:5.32|P-value:8.20E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.54|P-value:3.00E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:3.30E-11 ID:SGTC_386|Compound:1509-0011|FD-Score:8.24|P-value:5.50E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.46|P-value:8.71E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.75|P-value:3.60E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.43|P-value:9.56E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.10|P-value:1.05E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.66|P-value:4.66E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.78|P-value:3.30E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.96|P-value:1.79E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.79|P-value:3.07E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.62|P-value:5.31E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.75|P-value:3.63E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.55|P-value:6.82E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.02|P-value:1.47E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.41|P-value:3.54E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.21|P-value:7.36E-5 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.75|P-value:3.66E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.46|P-value:2.85E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.72|P-value:4.07E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.52|P-value:7.63E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-3.53|P-value:7.21E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.51|P-value:7.64E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.57|P-value:6.49E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.65|P-value:4.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.89|P-value:5.59E-8 ID:SGTC_2440|Compound:5628896|FD-Score:-3.43|P-value:9.64E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.74|P-value:9.65E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.95|P-value:1.84E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.59|P-value:6.03E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.79|P-value:3.08E-4 ID:SGTC_3056|Compound:9094900|FD-Score:5.04|P-value:2.80E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.47|P-value:8.75E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.76|P-value:3.47E-4 ID:SGTC_3148|Compound:9097893|FD-Score:14.20|P-value:1.27E-37 ID:SGTC_3151|Compound:9099821|FD-Score:-5.54|P-value:2.79E-7 ID:SGTC_3153|Compound:9100258|FD-Score:8.31|P-value:3.34E-14 ID:SGTC_3154|Compound:9100113|FD-Score:11.10|P-value:8.45E-24 ID:SGTC_3157|Compound:9099274|FD-Score:8.13|P-value:1.17E-13 ID:SGTC_3158|Compound:9100007|FD-Score:6.58|P-value:1.52E-9 ID:SGTC_3341|Compound:9147222|FD-Score:3.96|P-value:1.77E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.93|P-value:2.02E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.13|P-value:1.63E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:3.78|P-value:3.24E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:10.50|P-value:2.12E-21 ID:SGTC_149|Compound:3970-0822|FD-Score:4.47|P-value:2.85E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.51|P-value:7.88E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.46|P-value:8.88E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.28|P-value:5.69E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.37|P-value:4.08E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.76|P-value:3.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:23.00|P-value:1.58E-95 ID:SGTC_253|Compound:dyclonine|FD-Score:5.32|P-value:8.20E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.54|P-value:3.00E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:3.30E-11 ID:SGTC_386|Compound:1509-0011|FD-Score:8.24|P-value:5.50E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.46|P-value:8.71E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.75|P-value:3.60E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.43|P-value:9.56E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.10|P-value:1.05E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.66|P-value:4.66E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.78|P-value:3.30E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.96|P-value:1.79E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.79|P-value:3.07E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.62|P-value:5.31E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.75|P-value:3.63E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.55|P-value:6.82E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.02|P-value:1.47E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.41|P-value:3.54E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.21|P-value:7.36E-5 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.75|P-value:3.66E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.46|P-value:2.85E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.72|P-value:4.07E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.52|P-value:7.63E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-3.53|P-value:7.21E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.51|P-value:7.64E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.57|P-value:6.49E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.65|P-value:4.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.89|P-value:5.59E-8 ID:SGTC_2440|Compound:5628896|FD-Score:-3.43|P-value:9.64E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.74|P-value:9.65E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.95|P-value:1.84E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.59|P-value:6.03E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.79|P-value:3.08E-4 ID:SGTC_3056|Compound:9094900|FD-Score:5.04|P-value:2.80E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.47|P-value:8.75E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.76|P-value:3.47E-4 ID:SGTC_3148|Compound:9097893|FD-Score:14.20|P-value:1.27E-37 ID:SGTC_3151|Compound:9099821|FD-Score:-5.54|P-value:2.79E-7 ID:SGTC_3153|Compound:9100258|FD-Score:8.31|P-value:3.34E-14 ID:SGTC_3154|Compound:9100113|FD-Score:11.10|P-value:8.45E-24 ID:SGTC_3157|Compound:9099274|FD-Score:8.13|P-value:1.17E-13 ID:SGTC_3158|Compound:9100007|FD-Score:6.58|P-value:1.52E-9 ID:SGTC_3341|Compound:9147222|FD-Score:3.96|P-value:1.77E-4

Top fitness defect scores for YDL068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 23.00 5.3 µM 1.58E-95 40 7.31E-117
2 SGTC_3148 9097893 14.20 49.5 µM 1.27E-37 1 8.99E-46
3 SGTC_3154 9100113 11.10 49.5 µM 8.45E-24 1 8.20E-29
4 SGTC_134 0269-0018 10.50 6.9 µM 2.12E-21 38 7.17E-26
5 SGTC_3153 9100258 8.31 49.5 µM 3.34E-14 2 4.77E-17
6 SGTC_386 1509-0011 8.24 3.1 µM 5.50E-14 60 8.79E-17
7 SGTC_3157 9099274 8.13 49.5 µM 1.17E-13 1 2.21E-16
8 SGTC_310 1273-0058 7.24 1.1 µM 3.30E-11 mitochondrial stress 111 2.22E-13
9 SGTC_3158 9100007 6.58 49.5 µM 1.52E-9 2 2.40E-11
10 SGTC_70 0141-0289 6.13 43.3 µM 1.63E-8 mitochondrial stress 79 4.38E-10
11 SGTC_2307 7538926 5.89 6.3 µM 5.59E-8 10 1.98E-9
12 SGTC_275 trichlorophene 5.54 5.7 µM 3.00E-7 mitochondrial stress 136 1.54E-8
13 SGTC_253 dyclonine 5.32 31.2 µM 8.20E-7 amide catabolism 9 5.27E-8
14 SGTC_3056 9094900 5.04 49.5 µM 2.80E-6 6 2.36E-7
15 SGTC_2452 5863136 4.74 48.4 µM 9.65E-6 12 1.07E-6
16 SGTC_149 3970-0822 4.47 46.1 µM 2.85E-5 tubulin folding & SWR complex 67 3.99E-6
17 SGTC_1544 7-methoxy-4-methylcoumarin 4.41 105.0 µM 3.54E-5 8 5.19E-6
18 SGTC_173 1273-0061 4.37 2.7 µM 4.08E-5 mitochondrial stress 170 6.18E-6
19 SGTC_168 3970-0862 4.28 530.5 µM 5.69E-5 101 9.27E-6
20 SGTC_1635 st007035 4.21 42.4 µM 7.36E-5 201 1.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.547 8.86E-261 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.536 6.59E-249 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.522 8.68E-234 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.511 1.53E-222 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.509 3.39E-221 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.503 2.45E-214 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.502 3.07E-214 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.497 3.05E-208 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.496 4.32E-208 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.491 3.29E-203 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.488 1.01E-200 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.487 6.33E-200 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.473 8.44E-187 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.471 4.55E-185 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.469 1.93E-183 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes