HIPHOP chemogenomics database

YDL068W_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL068W / YDL068W

Click on Significant Values for Screen Details

Top fitness defect scores for YDL068W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	23.00	5.3 µM	1.58E-95		40	7.31E-117
2	SGTC_3148	9097893	14.20	49.5 µM	1.27E-37		1	8.99E-46
3	SGTC_3154	9100113	11.10	49.5 µM	8.45E-24		1	8.20E-29
4	SGTC_134	0269-0018	10.50	6.9 µM	2.12E-21		38	7.17E-26
5	SGTC_3153	9100258	8.31	49.5 µM	3.34E-14		2	4.77E-17
6	SGTC_386	1509-0011	8.24	3.1 µM	5.50E-14		60	8.79E-17
7	SGTC_3157	9099274	8.13	49.5 µM	1.17E-13		1	2.21E-16
8	SGTC_310	1273-0058	7.24	1.1 µM	3.30E-11	mitochondrial stress	111	2.22E-13
9	SGTC_3158	9100007	6.58	49.5 µM	1.52E-9		2	2.40E-11
10	SGTC_70	0141-0289	6.13	43.3 µM	1.63E-8	mitochondrial stress	79	4.38E-10
11	SGTC_2307	7538926	5.89	6.3 µM	5.59E-8		10	1.98E-9
12	SGTC_275	trichlorophene	5.54	5.7 µM	3.00E-7	mitochondrial stress	136	1.54E-8
13	SGTC_253	dyclonine	5.32	31.2 µM	8.20E-7	amide catabolism	9	5.27E-8
14	SGTC_3056	9094900	5.04	49.5 µM	2.80E-6		6	2.36E-7
15	SGTC_2452	5863136	4.74	48.4 µM	9.65E-6		12	1.07E-6
16	SGTC_149	3970-0822	4.47	46.1 µM	2.85E-5	tubulin folding & SWR complex	67	3.99E-6
17	SGTC_1544	7-methoxy-4-methylcoumarin	4.41	105.0 µM	3.54E-5		8	5.19E-6
18	SGTC_173	1273-0061	4.37	2.7 µM	4.08E-5	mitochondrial stress	170	6.18E-6
19	SGTC_168	3970-0862	4.28	530.5 µM	5.69E-5		101	9.27E-6
20	SGTC_1635	st007035	4.21	42.4 µM	7.36E-5		201	1.27E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.547	8.86E-261	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.536	6.59E-249	YDR231C	COX20	hom	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.522	8.68E-234	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.511	1.53E-222	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.509	3.39E-221	YML129C	COX14	hom	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.503	2.45E-214	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.502	3.07E-214	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.497	3.05E-208	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.496	4.32E-208	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.491	3.29E-203	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.488	1.01E-200	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.487	6.33E-200	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.473	8.44E-187	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.471	4.55E-185	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.469	1.93E-183	YGL107C	RMD9	hom	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes