YDL072C / YET3

Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL072C / YET3

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.42|P-value:2.39E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:16.90|P-value:1.05E-66 ID:SGTC_115|Compound:0527-0192|FD-Score:8.12|P-value:5.75E-17 ID:SGTC_188|Compound:3229-0966|FD-Score:5.66|P-value:3.79E-9 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.08|P-value:8.25E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.42|P-value:2.45E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.47|P-value:2.05E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.72|P-value:7.44E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:3.11|P-value:7.60E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.56|P-value:1.38E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.18|P-value:5.75E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.45|P-value:2.16E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.10|P-value:7.57E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.12|P-value:1.31E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.22|P-value:5.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.05|P-value:3.13E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.68|P-value:8.56E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.64|P-value:1.01E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.90|P-value:2.85E-7 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.05|P-value:9.44E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.30|P-value:3.31E-8 ID:SGTC_2024|Compound:5144227|FD-Score:-3.59|P-value:1.22E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.18|P-value:5.98E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.17|P-value:6.25E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.64|P-value:9.88E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.52|P-value:1.65E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.09|P-value:7.83E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.35|P-value:3.19E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.58|P-value:1.29E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-3.35|P-value:3.06E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.83|P-value:4.65E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.25|P-value:4.68E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.61|P-value:5.23E-9 ID:SGTC_2705|Compound:st078069|FD-Score:-3.10|P-value:7.73E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.28|P-value:4.01E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.11|P-value:7.31E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.14|P-value:7.97E-8 ID:SGTC_2903|Compound:5923464|FD-Score:-4.27|P-value:6.50E-6 ID:SGTC_2917|Compound:7979103|FD-Score:4.34|P-value:4.72E-6 ID:SGTC_2969|Compound:9091408|FD-Score:-3.37|P-value:2.82E-4 ID:SGTC_2971|Compound:9092186|FD-Score:7.68|P-value:2.39E-15 ID:SGTC_2975|Compound:9084847|FD-Score:9.94|P-value:1.73E-24 ID:SGTC_3153|Compound:9100258|FD-Score:-3.42|P-value:2.35E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.42|P-value:2.39E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:16.90|P-value:1.05E-66 ID:SGTC_115|Compound:0527-0192|FD-Score:8.12|P-value:5.75E-17 ID:SGTC_188|Compound:3229-0966|FD-Score:5.66|P-value:3.79E-9 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.08|P-value:8.25E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.42|P-value:2.45E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.47|P-value:2.05E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.72|P-value:7.44E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:3.11|P-value:7.60E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.56|P-value:1.38E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.18|P-value:5.75E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.45|P-value:2.16E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.10|P-value:7.57E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.12|P-value:1.31E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.22|P-value:5.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.05|P-value:3.13E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.68|P-value:8.56E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.64|P-value:1.01E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.90|P-value:2.85E-7 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.05|P-value:9.44E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.30|P-value:3.31E-8 ID:SGTC_2024|Compound:5144227|FD-Score:-3.59|P-value:1.22E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.18|P-value:5.98E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.17|P-value:6.25E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.64|P-value:9.88E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.52|P-value:1.65E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.09|P-value:7.83E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.35|P-value:3.19E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.58|P-value:1.29E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-3.35|P-value:3.06E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.83|P-value:4.65E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.25|P-value:4.68E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.61|P-value:5.23E-9 ID:SGTC_2705|Compound:st078069|FD-Score:-3.10|P-value:7.73E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.28|P-value:4.01E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.11|P-value:7.31E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.14|P-value:7.97E-8 ID:SGTC_2903|Compound:5923464|FD-Score:-4.27|P-value:6.50E-6 ID:SGTC_2917|Compound:7979103|FD-Score:4.34|P-value:4.72E-6 ID:SGTC_2969|Compound:9091408|FD-Score:-3.37|P-value:2.82E-4 ID:SGTC_2971|Compound:9092186|FD-Score:7.68|P-value:2.39E-15 ID:SGTC_2975|Compound:9084847|FD-Score:9.94|P-value:1.73E-24 ID:SGTC_3153|Compound:9100258|FD-Score:-3.42|P-value:2.35E-4

Top fitness defect scores for YDL072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_114 0364-0001 16.90 490.3 µM 1.05E-66 1 3.76E-64
2 SGTC_2975 9084847 9.94 53.7 µM 1.73E-24 1 1.33E-23
3 SGTC_115 0527-0192 8.12 112.0 µM 5.75E-17 8 2.25E-16
4 SGTC_2971 9092186 7.68 9.9 µM 2.39E-15 ergosterol biosynthesis 3 8.06E-15
5 SGTC_188 3229-0966 5.66 278.5 µM 3.79E-9 10 7.36E-9
6 SGTC_2651 1327-0036 5.61 5.0 µM 5.23E-9 83 1.00E-8
7 SGTC_1941 st076221 5.30 61.8 µM 3.31E-8 sphingolipid biosynthesis & PDR1 38 5.92E-8
8 SGTC_2858 9025781 5.14 9.0 µM 7.97E-8 sphingolipid biosynthesis & PDR1 63 1.38E-7
9 SGTC_1563 conessine 4.90 56.1 µM 2.85E-7 4 4.70E-7
10 SGTC_743 1275-0778 4.72 158.0 µM 7.44E-7 excess fatty acid 21 1.18E-6
11 SGTC_2917 7979103 4.34 53.8 µM 4.72E-6 21 6.99E-6
12 SGTC_1452 4194-0072 4.12 190.0 µM 1.31E-5 9 1.87E-5
13 SGTC_2571 chrysanthemic acid 3.83 100.0 µM 4.65E-5 22 6.33E-5
14 SGTC_2516 gossypol 3.58 71.5 µM 1.29E-4 23 1.69E-4
15 SGTC_2429 5902844 3.52 64.4 µM 1.65E-4 45 2.14E-4
16 SGTC_1569 carminic acid 3.51 40.6 µM 1.70E-4 32 2.21E-4
17 SGTC_388 3',4'-dichloroisocoumarin 3.47 16.7 µM 2.05E-4 27 2.64E-4
18 SGTC_1311 1190-0148 3.45 100.0 µM 2.16E-4 azole & statin 42 2.78E-4
19 SGTC_1100 amiodarone 3.43 5.1 µM 2.36E-4 31 3.02E-4
20 SGTC_379 3970-0972 3.42 5.9 µM 2.45E-4 tubulin folding & SWR complex 54 3.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.50E-48 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.223 5.30E-39 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.206 1.40E-33 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.199 3.02E-31 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.195 3.80E-30 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.180 6.84E-26 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.179 1.71E-25 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.175 1.63E-24 YDR306C_p YDR306C_p hom F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
0.172 1.48E-23 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.167 3.58E-22 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.165 6.46E-22 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.164 8.95E-22 YGR024C THG1 het tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
0.161 6.01E-21 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.159 1.93E-20 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.158 3.35E-20 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p