YDL073W_p

Putative protein of unknown function; YDL073W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL073W / YDL073W

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:3.59|P-value:6.17E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.85|P-value:1.96E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.44|P-value:4.41E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:4.70|P-value:1.11E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.08|P-value:8.77E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.87|P-value:2.38E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.51|P-value:3.06E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:4.20|P-value:7.61E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.50|P-value:8.03E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.56|P-value:1.92E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.52|P-value:7.64E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.06|P-value:1.24E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.67|P-value:1.22E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.96|P-value:1.76E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.56|P-value:6.79E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.90|P-value:2.15E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.67|P-value:4.71E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.70|P-value:4.28E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:8.98|P-value:1.91E-16 ID:SGTC_1526|Compound:st051518|FD-Score:3.45|P-value:9.37E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.67|P-value:4.77E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.60|P-value:5.92E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.44|P-value:9.76E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.37|P-value:3.93E-5 ID:SGTC_2168|Compound:5727979|FD-Score:4.19|P-value:7.72E-5 ID:SGTC_2211|Compound:7117706|FD-Score:3.48|P-value:8.51E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.28|P-value:5.68E-5 ID:SGTC_2386|Compound:9075165|FD-Score:4.03|P-value:1.39E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.67|P-value:4.65E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.92|P-value:1.54E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.44|P-value:9.69E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.69|P-value:4.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.68|P-value:4.54E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.98|P-value:2.43E-6 ID:SGTC_2848|Compound:9016370|FD-Score:3.52|P-value:7.65E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.76|P-value:9.15E-8 ID:SGTC_2896|Compound:9052656|FD-Score:4.48|P-value:2.64E-5 ID:SGTC_2904|Compound:7225135|FD-Score:3.60|P-value:5.87E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-3.72|P-value:3.11E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.59|P-value:6.17E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.85|P-value:1.96E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.44|P-value:4.41E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:4.70|P-value:1.11E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.08|P-value:8.77E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.87|P-value:2.38E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.51|P-value:3.06E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:4.20|P-value:7.61E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.50|P-value:8.03E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.56|P-value:1.92E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.52|P-value:7.64E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.06|P-value:1.24E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.67|P-value:1.22E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.96|P-value:1.76E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.56|P-value:6.79E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.90|P-value:2.15E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.67|P-value:4.71E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.70|P-value:4.28E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:8.98|P-value:1.91E-16 ID:SGTC_1526|Compound:st051518|FD-Score:3.45|P-value:9.37E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.67|P-value:4.77E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.60|P-value:5.92E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.44|P-value:9.76E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.37|P-value:3.93E-5 ID:SGTC_2168|Compound:5727979|FD-Score:4.19|P-value:7.72E-5 ID:SGTC_2211|Compound:7117706|FD-Score:3.48|P-value:8.51E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.28|P-value:5.68E-5 ID:SGTC_2386|Compound:9075165|FD-Score:4.03|P-value:1.39E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.67|P-value:4.65E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.92|P-value:1.54E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.44|P-value:9.69E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.69|P-value:4.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.68|P-value:4.54E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.98|P-value:2.43E-6 ID:SGTC_2848|Compound:9016370|FD-Score:3.52|P-value:7.65E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.76|P-value:9.15E-8 ID:SGTC_2896|Compound:9052656|FD-Score:4.48|P-value:2.64E-5 ID:SGTC_2904|Compound:7225135|FD-Score:3.60|P-value:5.87E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-3.72|P-value:3.11E-4

Top fitness defect scores for YDL073W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1376 2910-0861 8.98 41.3 µM 1.91E-16 1 1.38E-19
2 SGTC_2881 9058953 5.76 52.0 µM 9.15E-8 4 4.11E-9
3 SGTC_453 enantio-paf c16 5.51 10.0 µM 3.06E-7 68 1.76E-8
4 SGTC_58 0957-0393 5.44 9.0 µM 4.41E-7 cell wall 246 2.73E-8
5 SGTC_90 0870-0863 4.70 4.6 µM 1.11E-5 31 1.33E-6
6 SGTC_1071 trifluoperazine 4.67 6.3 µM 1.22E-5 15 1.49E-6
7 SGTC_711 k292-0785 4.56 179.0 µM 1.92E-5 DNA intercalators 10 2.59E-6
8 SGTC_2896 9052656 4.48 71.4 µM 2.64E-5 endomembrane recycling 82 3.79E-6
9 SGTC_2085 5307070 4.37 144.1 µM 3.93E-5 superoxide 20 6.12E-6
10 SGTC_2322 7413319 4.28 38.2 µM 5.68E-5 ERAD & cell cycle 136 9.55E-6
11 SGTC_528 3492-0019 4.20 172.0 µM 7.61E-5 calcium & mitochondrial duress 201 1.36E-5
12 SGTC_2168 5727979 4.19 200.0 µM 7.72E-5 15 1.38E-5
13 SGTC_1000 4048-0884 4.06 8.7 µM 1.24E-4 copper-dependent oxidative stress 29 2.45E-5
14 SGTC_2386 9075165 4.03 157.4 µM 1.39E-4 7 2.79E-5
15 SGTC_1104 tacrolimus 3.96 29.8 µM 1.76E-4 31 3.72E-5
16 SGTC_1196 1588-0294 3.90 184.0 µM 2.15E-4 13 4.73E-5
17 SGTC_351 caspofungin 3.87 25.0 nM 2.38E-4 cell wall 103 5.34E-5
18 SGTC_1287 0971-0001 3.70 34.6 µM 4.28E-4 sphingolipid biosynthesis & PDR1 53 1.08E-4
19 SGTC_2736 butenafine 3.69 14.7 µM 4.35E-4 35 1.10E-4
20 SGTC_2752 diclazuril 3.68 33.1 µM 4.54E-4 139 1.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.34E-24 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.164 1.14E-21 YOR034C-A_p YOR034C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.155 1.61E-19 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 7.49E-19 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.148 7.76E-18 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.142 1.61E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.139 6.75E-16 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.132 1.47E-14 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.130 3.84E-14 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.130 4.31E-14 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.129 7.79E-14 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.127 1.39E-13 YBR208C DUR1,2 hom Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
0.127 1.44E-13 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.125 3.67E-13 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.124 4.72E-13 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids