YDL076C / RXT3

Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL076C / RXT3

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:5.91|P-value:1.08E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:3.27|P-value:9.79E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.61|P-value:3.18E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.71|P-value:2.22E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.35|P-value:7.69E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.51|P-value:4.50E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.12|P-value:4.81E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:4.62|P-value:5.98E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.46|P-value:5.24E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.76|P-value:2.49E-8 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.48|P-value:1.11E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.33|P-value:2.03E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.80|P-value:1.61E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.43|P-value:5.86E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.03|P-value:6.73E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.80|P-value:1.59E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.80|P-value:1.63E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.55|P-value:3.84E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.34|P-value:1.99E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.46|P-value:1.22E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.49|P-value:1.06E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.34|P-value:7.86E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.78|P-value:3.02E-6 ID:SGTC_1805|Compound:st050013|FD-Score:-3.75|P-value:1.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.58|P-value:6.48E-8 ID:SGTC_1937|Compound:st074714|FD-Score:4.77|P-value:3.14E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.43|P-value:5.78E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.63|P-value:2.97E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.48|P-value:4.95E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.32|P-value:8.35E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.95|P-value:9.15E-5 ID:SGTC_2157|Compound:5649910|FD-Score:4.61|P-value:6.42E-6 ID:SGTC_2289|Compound:7946404|FD-Score:5.37|P-value:1.84E-7 ID:SGTC_2361|Compound:9034121|FD-Score:4.56|P-value:7.88E-6 ID:SGTC_2369|Compound:9071472|FD-Score:6.36|P-value:8.76E-10 ID:SGTC_2382|Compound:9035899|FD-Score:-3.93|P-value:1.01E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.59|P-value:3.38E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-5.17|P-value:4.90E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.42|P-value:6.06E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.74|P-value:1.96E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.10|P-value:5.29E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.03|P-value:9.77E-7 ID:SGTC_2810|Compound:7959871|FD-Score:4.58|P-value:7.30E-6 ID:SGTC_3109|Compound:9122853|FD-Score:4.67|P-value:4.91E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-3.42|P-value:6.03E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.81|P-value:1.56E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.89|P-value:1.16E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.54|P-value:8.59E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:5.91|P-value:1.08E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:3.27|P-value:9.79E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.61|P-value:3.18E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.71|P-value:2.22E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.35|P-value:7.69E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.51|P-value:4.50E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.12|P-value:4.81E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:4.62|P-value:5.98E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.46|P-value:5.24E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.76|P-value:2.49E-8 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.48|P-value:1.11E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.33|P-value:2.03E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.80|P-value:1.61E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.43|P-value:5.86E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.03|P-value:6.73E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.80|P-value:1.59E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.80|P-value:1.63E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.55|P-value:3.84E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.34|P-value:1.99E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.46|P-value:1.22E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.49|P-value:1.06E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.34|P-value:7.86E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.78|P-value:3.02E-6 ID:SGTC_1805|Compound:st050013|FD-Score:-3.75|P-value:1.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.58|P-value:6.48E-8 ID:SGTC_1937|Compound:st074714|FD-Score:4.77|P-value:3.14E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.43|P-value:5.78E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.63|P-value:2.97E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.48|P-value:4.95E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.32|P-value:8.35E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.95|P-value:9.15E-5 ID:SGTC_2157|Compound:5649910|FD-Score:4.61|P-value:6.42E-6 ID:SGTC_2289|Compound:7946404|FD-Score:5.37|P-value:1.84E-7 ID:SGTC_2361|Compound:9034121|FD-Score:4.56|P-value:7.88E-6 ID:SGTC_2369|Compound:9071472|FD-Score:6.36|P-value:8.76E-10 ID:SGTC_2382|Compound:9035899|FD-Score:-3.93|P-value:1.01E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.59|P-value:3.38E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-5.17|P-value:4.90E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.42|P-value:6.06E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.74|P-value:1.96E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.10|P-value:5.29E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.03|P-value:9.77E-7 ID:SGTC_2810|Compound:7959871|FD-Score:4.58|P-value:7.30E-6 ID:SGTC_3109|Compound:9122853|FD-Score:4.67|P-value:4.91E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-3.42|P-value:6.03E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.81|P-value:1.56E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.89|P-value:1.16E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.54|P-value:8.59E-6

Top fitness defect scores for YDL076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2369 9071472 6.36 200.0 µM 8.76E-10 2 1.02E-10
2 SGTC_22 0964-0034 5.91 14.5 µM 1.08E-8 unfolded protein response 19 1.67E-9
3 SGTC_1133 3473-0247 5.76 50.0 µM 2.49E-8 RSC complex & mRNA processing 10 4.23E-9
4 SGTC_1818 st052136 5.58 56.3 µM 6.48E-8 NEO1-PIK1 15 1.23E-8
5 SGTC_2289 7946404 5.37 165.1 µM 1.84E-7 47 3.93E-8
6 SGTC_2688 kanamycin b 5.03 96.7 µM 9.77E-7 calcium & mitochondrial duress 241 2.51E-7
7 SGTC_1937 st074714 4.77 47.2 µM 3.14E-6 25 9.17E-7
8 SGTC_3109 9122853 4.67 49.5 µM 4.91E-6 2 1.51E-6
9 SGTC_878 0828-0289 4.62 13.7 µM 5.98E-6 30 1.88E-6
10 SGTC_2157 5649910 4.61 96.4 µM 6.42E-6 12 2.03E-6
11 SGTC_2810 7959871 4.58 45.5 µM 7.30E-6 copper-dependent oxidative stress 27 2.34E-6
12 SGTC_2361 9034121 4.56 116.0 µM 7.88E-6 RSC complex & mRNA processing 11 2.55E-6
13 SGTC_3304 9125678 4.54 46.1 µM 8.59E-6 31 2.81E-6
14 SGTC_1597 7-benzyloxygramine 4.49 47.5 µM 1.06E-5 calcium & mitochondrial duress 89 3.53E-6
15 SGTC_1147 3809-1045 4.48 12.3 µM 1.11E-5 14 3.73E-6
16 SGTC_1367 1812-0510 4.46 76.9 µM 1.22E-5 10 4.17E-6
17 SGTC_1364 1653-0028 4.34 37.6 µM 1.99E-5 14 7.12E-6
18 SGTC_1148 3909-7663 4.33 27.7 µM 2.03E-5 7 7.29E-6
19 SGTC_709 3807-1509 4.12 243.0 µM 4.81E-5 RSC complex & mRNA processing 11 1.90E-5
20 SGTC_1230 0170-0365 4.03 3.8 µM 6.73E-5 endomembrane recycling 62 2.76E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.04E-18 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.122 1.10E-12 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.120 2.54E-12 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.119 5.21E-12 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.118 7.79E-12 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.117 1.30E-11 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.112 9.29E-11 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.111 1.37E-10 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107 4.49E-10 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.098 1.28E-8 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.097 1.67E-8 YBR208C DUR1,2 hom Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
0.097 1.93E-8 YDR395W SXM1 hom Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
0.096 2.23E-8 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.095 3.26E-8 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.094 5.11E-8 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency