YDL079C / MRK1

Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL079C / MRK1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.08|P-value:5.06E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.90|P-value:1.77E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.46|P-value:1.20E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.38|P-value:1.65E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.17|P-value:3.92E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.10|P-value:5.14E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.26|P-value:2.70E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.58|P-value:5.70E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.79|P-value:2.57E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:-2.89|P-value:9.96E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.18|P-value:3.75E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.22|P-value:3.18E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.92|P-value:7.51E-8 ID:SGTC_822|Compound:1487-0950|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.45|P-value:1.16E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.00|P-value:1.11E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.27|P-value:2.62E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.61|P-value:6.37E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.85|P-value:2.16E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-4.26|P-value:2.72E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.62|P-value:1.19E-9 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.99|P-value:1.17E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.17|P-value:2.06E-8 ID:SGTC_1954|Compound:st077032|FD-Score:-3.17|P-value:3.50E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.04|P-value:6.32E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.35|P-value:1.95E-6 ID:SGTC_2318|Compound:6029776|FD-Score:3.51|P-value:9.68E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.91|P-value:9.25E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.32|P-value:2.13E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.37|P-value:1.72E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-6.64|P-value:7.06E-13 ID:SGTC_2591|Compound:skatole|FD-Score:-5.64|P-value:9.12E-10 ID:SGTC_2610|Compound:ononetin|FD-Score:-2.92|P-value:9.10E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.22|P-value:3.13E-4 ID:SGTC_2786|Compound:7743617|FD-Score:5.39|P-value:5.32E-9 ID:SGTC_2793|Compound:7325131|FD-Score:3.17|P-value:3.81E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.87|P-value:2.05E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-2.91|P-value:9.30E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.99|P-value:1.02E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-4.84|P-value:1.22E-7 ID:SGTC_2854|Compound:9024559|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.97|P-value:7.44E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.70|P-value:4.26E-5 ID:SGTC_2975|Compound:9084847|FD-Score:4.80|P-value:1.71E-7 ID:SGTC_2976|Compound:9009005|FD-Score:5.10|P-value:3.12E-8 ID:SGTC_2978|Compound:9011784|FD-Score:4.06|P-value:8.20E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-4.93|P-value:7.07E-8 ID:SGTC_2985|Compound:9022375|FD-Score:7.88|P-value:2.88E-17 ID:SGTC_3210|Compound:9128157|FD-Score:11.20|P-value:4.13E-33 ID:SGTC_3216|Compound:9129716|FD-Score:-3.14|P-value:3.92E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.55|P-value:7.38E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.08|P-value:5.06E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.90|P-value:1.77E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.46|P-value:1.20E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.38|P-value:1.65E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.17|P-value:3.92E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.10|P-value:5.14E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.26|P-value:2.70E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.58|P-value:5.70E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.79|P-value:2.57E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:-2.89|P-value:9.96E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.18|P-value:3.75E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.22|P-value:3.18E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.92|P-value:7.51E-8 ID:SGTC_822|Compound:1487-0950|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.45|P-value:1.16E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.00|P-value:1.11E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.27|P-value:2.62E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.61|P-value:6.37E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.85|P-value:2.16E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-4.26|P-value:2.72E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.62|P-value:1.19E-9 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.99|P-value:1.17E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.17|P-value:2.06E-8 ID:SGTC_1954|Compound:st077032|FD-Score:-3.17|P-value:3.50E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.04|P-value:6.32E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.35|P-value:1.95E-6 ID:SGTC_2318|Compound:6029776|FD-Score:3.51|P-value:9.68E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.91|P-value:9.25E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.32|P-value:2.13E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.37|P-value:1.72E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-6.64|P-value:7.06E-13 ID:SGTC_2591|Compound:skatole|FD-Score:-5.64|P-value:9.12E-10 ID:SGTC_2610|Compound:ononetin|FD-Score:-2.92|P-value:9.10E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.22|P-value:3.13E-4 ID:SGTC_2786|Compound:7743617|FD-Score:5.39|P-value:5.32E-9 ID:SGTC_2793|Compound:7325131|FD-Score:3.17|P-value:3.81E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.87|P-value:2.05E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-2.91|P-value:9.30E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.99|P-value:1.02E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-4.84|P-value:1.22E-7 ID:SGTC_2854|Compound:9024559|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.97|P-value:7.44E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.70|P-value:4.26E-5 ID:SGTC_2975|Compound:9084847|FD-Score:4.80|P-value:1.71E-7 ID:SGTC_2976|Compound:9009005|FD-Score:5.10|P-value:3.12E-8 ID:SGTC_2978|Compound:9011784|FD-Score:4.06|P-value:8.20E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-4.93|P-value:7.07E-8 ID:SGTC_2985|Compound:9022375|FD-Score:7.88|P-value:2.88E-17 ID:SGTC_3210|Compound:9128157|FD-Score:11.20|P-value:4.13E-33 ID:SGTC_3216|Compound:9129716|FD-Score:-3.14|P-value:3.92E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.55|P-value:7.38E-5

Top fitness defect scores for YDL079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3210 9128157 11.20 49.5 µM 4.13E-33 1 1.62E-29
2 SGTC_2985 9022375 7.88 71.4 µM 2.88E-17 RPP1 & pyrimidine depletion 3 1.70E-15
3 SGTC_1874 staurosporine 5.62 7.6 µM 1.19E-9 cell wall signaling 13 9.54E-9
4 SGTC_2786 7743617 5.39 45.5 µM 5.32E-9 5 3.61E-8
5 SGTC_1883 5-benzylidenerhodanine 5.17 20.0 µM 2.06E-8 TRP & mitochondrial translation 26 1.20E-7
6 SGTC_2976 9009005 5.10 19.5 µM 3.12E-8 18 1.73E-7
7 SGTC_2975 9084847 4.80 53.7 µM 1.71E-7 7 7.88E-7
8 SGTC_604 1000-0114 4.58 314.0 µM 5.70E-7 9 2.29E-6
9 SGTC_430 0958-0115 4.38 16.4 µM 1.65E-6 19 5.91E-6
10 SGTC_2316 5844804 4.35 197.4 µM 1.95E-6 21 6.86E-6
11 SGTC_2978 9011784 4.06 43.0 µM 8.20E-6 25 2.46E-5
12 SGTC_1262 0737-0114 4.00 49.6 µM 1.11E-5 18 3.21E-5
13 SGTC_1881 5652484 3.99 16.0 µM 1.17E-5 TRP & mitochondrial translation 29 3.37E-5
14 SGTC_822 1487-0950 3.95 154.0 µM 1.38E-5 11 3.89E-5
15 SGTC_1018 4259-0013 3.95 28.1 µM 1.38E-5 19 3.90E-5
16 SGTC_405 ebelactone b 3.90 50.0 µM 1.77E-5 19 4.88E-5
17 SGTC_2807 7945238 3.87 52.0 µM 2.05E-5 25 5.55E-5
18 SGTC_1728 st035614 3.85 33.8 µM 2.16E-5 57 5.82E-5
19 SGTC_2957 9076800 3.70 11.5 µM 4.26E-5 26 1.07E-4
20 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.61 85.4 µM 6.37E-5 32 1.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.96E-15 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.122 1.08E-12 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.118 6.46E-12 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.118 8.24E-12 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.111 1.26E-10 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function
0.108 3.72E-10 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.103 1.88E-9 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.103 1.97E-9 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.102 3.87E-9 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
0.100 7.09E-9 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.098 1.14E-8 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.097 1.55E-8 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.094 4.39E-8 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.094 4.81E-8 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.092 1.08E-7 YFR022W ROG3 hom Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication