YDL085C-A_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL085C-A / YDL085C-A

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-4.50|P-value:3.11E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.11|P-value:8.69E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:4.53|P-value:3.09E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:3.49|P-value:2.56E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.39|P-value:3.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.54|P-value:3.28E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:3.62|P-value:1.55E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.12|P-value:9.63E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.75|P-value:9.34E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.80|P-value:8.51E-7 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.05|P-value:2.68E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.37|P-value:6.73E-6 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.28|P-value:5.57E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.15|P-value:1.80E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.12|P-value:9.65E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.11|P-value:2.14E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-3.38|P-value:3.34E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.36|P-value:4.19E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.21|P-value:6.96E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.42|P-value:2.92E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.17|P-value:7.92E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.52|P-value:2.27E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.48|P-value:2.28E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.14|P-value:1.83E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.73|P-value:1.18E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.25|P-value:6.08E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-4.29|P-value:8.10E-6 ID:SGTC_2988|Compound:9073640|FD-Score:4.52|P-value:3.24E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-3.11|P-value:8.72E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.52|P-value:2.30E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.50|P-value:3.11E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.11|P-value:8.69E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:4.53|P-value:3.09E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:3.49|P-value:2.56E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.39|P-value:3.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.54|P-value:3.28E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:3.62|P-value:1.55E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.12|P-value:9.63E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.75|P-value:9.34E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.80|P-value:8.51E-7 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.05|P-value:2.68E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.37|P-value:6.73E-6 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.28|P-value:5.57E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.15|P-value:1.80E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.12|P-value:9.65E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.11|P-value:2.14E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-3.38|P-value:3.34E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.36|P-value:4.19E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.21|P-value:6.96E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.42|P-value:2.92E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.17|P-value:7.92E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.52|P-value:2.27E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.48|P-value:2.28E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.14|P-value:1.83E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.73|P-value:1.18E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.25|P-value:6.08E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-4.29|P-value:8.10E-6 ID:SGTC_2988|Compound:9073640|FD-Score:4.52|P-value:3.24E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-3.11|P-value:8.72E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.52|P-value:2.30E-4

Top fitness defect scores for YDL085C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 6.54 5.3 µM 3.28E-11 274 3.00E-11
2 SGTC_1331 1472-0049 4.80 76.2 µM 8.51E-7 4 7.91E-7
3 SGTC_2636 apigenin dimethyl ether 4.73 100.0 µM 1.18E-6 21 1.10E-6
4 SGTC_98 0074-0023 4.53 107.7 µM 3.09E-6 Golgi 25 2.88E-6
5 SGTC_2988 9073640 4.52 71.4 µM 3.24E-6 14 3.02E-6
6 SGTC_1442 4112-3290 4.37 3.0 µM 6.73E-6 5 6.29E-6
7 SGTC_1533 dihydroergotamine mesylate 4.15 29.4 µM 1.80E-5 DNA intercalators 12 1.69E-5
8 SGTC_2630 antimycin a 4.14 100.0 µM 1.83E-5 mitochondrial processes 34 1.71E-5
9 SGTC_1554 st069299 4.11 38.7 µM 2.14E-5 19 2.00E-5
10 SGTC_1334 1486-0610 4.05 236.0 µM 2.68E-5 60S ribosome export 14 2.51E-5
11 SGTC_990 3985-0011 3.75 41.3 µM 9.34E-5 amide catabolism 28 8.79E-5
12 SGTC_2798 7813637 3.69 45.5 µM 1.20E-4 42 1.13E-4
13 SGTC_310 1273-0058 3.62 1.1 µM 1.55E-4 mitochondrial stress 268 1.46E-4
14 SGTC_43 0570-0105 3.54 72.5 µM 2.12E-4 ERG2 126 2.00E-4
15 SGTC_2512 diallyl trisulfide 3.52 49.2 µM 2.27E-4 15 2.14E-4
16 SGTC_3263 9137018 3.52 49.5 µM 2.30E-4 30 2.17E-4
17 SGTC_192 3455-0609 3.49 60.9 µM 2.56E-4 23 2.42E-4
18 SGTC_963 1269-2853 3.40 151.0 µM 3.52E-4 45 3.33E-4
19 SGTC_193 1273-0060 3.39 1.6 µM 3.66E-4 ergosterol biosynthesis 18 3.46E-4
20 SGTC_607 4491-0986 3.37 66.8 µM 3.98E-4 heme requiring 40 3.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 3.05E-44 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.229 5.46E-41 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.224 2.86E-39 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.221 3.03E-38 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.217 6.32E-37 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.213 9.13E-36 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.211 3.78E-35 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.208 3.65E-34 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.208 3.68E-34 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.208 5.60E-34 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.205 4.20E-33 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.203 2.11E-32 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.202 2.92E-32 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.198 5.64E-31 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.197 8.38E-31 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases