YDL089W / NUR1

Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL089W / NUR1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.90|P-value:1.03E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.41|P-value:5.82E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.15|P-value:3.86E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:3.47|P-value:4.83E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.63|P-value:2.74E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.74|P-value:1.84E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.40|P-value:6.11E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.15|P-value:3.99E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:6.10|P-value:3.19E-9 ID:SGTC_747|Compound:3448-8087|FD-Score:3.88|P-value:1.12E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.56|P-value:6.14E-8 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.33|P-value:1.86E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.45|P-value:5.10E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.54|P-value:3.76E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.82|P-value:1.37E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.74|P-value:1.86E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.30|P-value:2.11E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.30|P-value:8.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.26|P-value:9.54E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.47|P-value:1.03E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.72|P-value:1.98E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.27|P-value:9.45E-4 ID:SGTC_1751|Compound:st044839|FD-Score:-3.51|P-value:4.20E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.53|P-value:3.91E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.35|P-value:7.07E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.82|P-value:1.40E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.39|P-value:6.25E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-6.63|P-value:1.38E-10 ID:SGTC_2132|Compound:5317594|FD-Score:3.58|P-value:3.28E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.36|P-value:7.00E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.29|P-value:2.24E-5 ID:SGTC_2353|Compound:9059630|FD-Score:-5.44|P-value:1.12E-7 ID:SGTC_2355|Compound:9061122|FD-Score:-4.14|P-value:4.11E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.94|P-value:1.27E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.34|P-value:7.51E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.42|P-value:1.22E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-7.97|P-value:1.66E-14 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.77|P-value:1.67E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.39|P-value:6.28E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-4.76|P-value:3.00E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:4.19|P-value:3.29E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.56|P-value:3.57E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.55|P-value:3.33E-13 ID:SGTC_2894|Compound:9048625|FD-Score:-3.41|P-value:5.83E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.72|P-value:3.49E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.88|P-value:1.12E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.38|P-value:6.59E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.44|P-value:5.28E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.90|P-value:1.03E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.41|P-value:5.82E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.15|P-value:3.86E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:3.47|P-value:4.83E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.63|P-value:2.74E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.74|P-value:1.84E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.40|P-value:6.11E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.15|P-value:3.99E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:6.10|P-value:3.19E-9 ID:SGTC_747|Compound:3448-8087|FD-Score:3.88|P-value:1.12E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.56|P-value:6.14E-8 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.33|P-value:1.86E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.45|P-value:5.10E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.54|P-value:3.76E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.82|P-value:1.37E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.74|P-value:1.86E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.30|P-value:2.11E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.30|P-value:8.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.26|P-value:9.54E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.47|P-value:1.03E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.72|P-value:1.98E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.27|P-value:9.45E-4 ID:SGTC_1751|Compound:st044839|FD-Score:-3.51|P-value:4.20E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.53|P-value:3.91E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.35|P-value:7.07E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.82|P-value:1.40E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.39|P-value:6.25E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-6.63|P-value:1.38E-10 ID:SGTC_2132|Compound:5317594|FD-Score:3.58|P-value:3.28E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.36|P-value:7.00E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.29|P-value:2.24E-5 ID:SGTC_2353|Compound:9059630|FD-Score:-5.44|P-value:1.12E-7 ID:SGTC_2355|Compound:9061122|FD-Score:-4.14|P-value:4.11E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.94|P-value:1.27E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.34|P-value:7.51E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.42|P-value:1.22E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-7.97|P-value:1.66E-14 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.77|P-value:1.67E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.39|P-value:6.28E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-4.76|P-value:3.00E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:4.19|P-value:3.29E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.56|P-value:3.57E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.55|P-value:3.33E-13 ID:SGTC_2894|Compound:9048625|FD-Score:-3.41|P-value:5.83E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.72|P-value:3.49E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.88|P-value:1.12E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.38|P-value:6.59E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.44|P-value:5.28E-4

Top fitness defect scores for YDL089W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2858 9025781 7.55 9.0 µM 3.33E-13 sphingolipid biosynthesis & PDR1 33 2.15E-14
2 SGTC_743 1275-0778 6.10 158.0 µM 3.19E-9 excess fatty acid 11 5.25E-10
3 SGTC_764 1951-2361 5.56 146.0 µM 6.14E-8 10 1.36E-8
4 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 5.42 100.0 µM 1.22E-7 7 2.91E-8
5 SGTC_2582 agaric acid 4.94 100.0 µM 1.27E-6 redox potentiating 226 3.83E-7
6 SGTC_2939 9044578 4.72 71.4 µM 3.49E-6 26 1.16E-6
7 SGTC_1629 st005085 4.47 44.9 µM 1.03E-5 RPP1 & pyrimidine depletion 20 3.83E-6
8 SGTC_1096 rimcazole 4.33 32.2 µM 1.86E-5 3 7.31E-6
9 SGTC_2238 6671620 4.29 73.2 µM 2.24E-5 21 8.98E-6
10 SGTC_2730 imipramine 4.19 71.3 µM 3.29E-5 17 1.37E-5
11 SGTC_188 3229-0966 4.15 278.5 µM 3.86E-5 24 1.64E-5
12 SGTC_666 0272-0154 4.15 136.0 µM 3.99E-5 cell wall 50 1.69E-5
13 SGTC_43 0570-0105 3.90 72.5 µM 1.03E-4 ERG2 96 4.80E-5
14 SGTC_3033 9090887 3.88 49.5 µM 1.12E-4 fatty acid desaturase (OLE1) 24 5.27E-5
15 SGTC_747 3448-8087 3.88 38.7 µM 1.12E-4 28 5.29E-5
16 SGTC_1845 st056753 3.87 3.0 µM 1.17E-4 TSC3-RPN4 38 5.51E-5
17 SGTC_2057 5236571 3.83 38.3 µM 1.35E-4 RPP1 & pyrimidine depletion 35 6.47E-5
18 SGTC_2020 4017018 3.82 200.0 µM 1.40E-4 23 6.74E-5
19 SGTC_1787 fluconazole 3.81 80.0 µM 1.47E-4 iron homeostasis 28 7.08E-5
20 SGTC_1224 0823-0416 3.74 294.0 µM 1.86E-4 12 9.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.00E-22 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.125 3.62E-13 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.116 1.88E-11 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.110 1.69E-10 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.101 4.30E-9 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.097 2.20E-8 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.096 2.55E-8 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.090 1.56E-7 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 2.00E-7 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.090 2.06E-7 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.088 3.49E-7 YNR007C ATG3 hom E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p
0.088 3.78E-7 YIL035C CKA1 hom Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
0.085 7.37E-7 YPR060C ARO7 hom Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
0.084 1.25E-6 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.083 1.56E-6 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay