YDL092W / SRP14

Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL092W / SRP14

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.47|P-value:4.70E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.79|P-value:1.88E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.42|P-value:6.76E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.67|P-value:2.29E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.86|P-value:1.86E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.79|P-value:1.51E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.27|P-value:8.85E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:4.49|P-value:9.58E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:3.64|P-value:2.58E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.32|P-value:7.56E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.34|P-value:1.81E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.52|P-value:8.47E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:4.48|P-value:9.91E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.98|P-value:7.53E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.62|P-value:2.79E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:9.23|P-value:9.87E-19 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.78|P-value:1.95E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.48|P-value:9.49E-8 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.89|P-value:1.33E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.36|P-value:8.41E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.65|P-value:3.13E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.27|P-value:8.95E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.38|P-value:1.50E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.74|P-value:1.83E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.78|P-value:2.01E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.07|P-value:5.28E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.41|P-value:7.10E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.97|P-value:9.89E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.56|P-value:3.42E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.08|P-value:4.98E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.68|P-value:2.24E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.91|P-value:9.65E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-4.15|P-value:4.97E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.40|P-value:5.83E-4 ID:SGTC_2985|Compound:9022375|FD-Score:5.04|P-value:8.12E-7 ID:SGTC_3056|Compound:9094900|FD-Score:5.57|P-value:5.96E-8 ID:SGTC_3271|Compound:9137798|FD-Score:4.11|P-value:4.53E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.16|P-value:3.70E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.54|P-value:3.65E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.45|P-value:4.90E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.47|P-value:4.70E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.79|P-value:1.88E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.42|P-value:6.76E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.67|P-value:2.29E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.86|P-value:1.86E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.79|P-value:1.51E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.27|P-value:8.85E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:4.49|P-value:9.58E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:3.64|P-value:2.58E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.32|P-value:7.56E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.34|P-value:1.81E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.52|P-value:8.47E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:4.48|P-value:9.91E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.98|P-value:7.53E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.62|P-value:2.79E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:9.23|P-value:9.87E-19 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.78|P-value:1.95E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.48|P-value:9.49E-8 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.89|P-value:1.33E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.36|P-value:8.41E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.65|P-value:3.13E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.27|P-value:8.95E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.38|P-value:1.50E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.74|P-value:1.83E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.78|P-value:2.01E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.07|P-value:5.28E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.41|P-value:7.10E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.97|P-value:9.89E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.56|P-value:3.42E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.08|P-value:4.98E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.68|P-value:2.24E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.91|P-value:9.65E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-4.15|P-value:4.97E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.40|P-value:5.83E-4 ID:SGTC_2985|Compound:9022375|FD-Score:5.04|P-value:8.12E-7 ID:SGTC_3056|Compound:9094900|FD-Score:5.57|P-value:5.96E-8 ID:SGTC_3271|Compound:9137798|FD-Score:4.11|P-value:4.53E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.16|P-value:3.70E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.54|P-value:3.65E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.45|P-value:4.90E-4

Top fitness defect scores for YDL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_996 3970-0799 9.23 1.8 µM 9.87E-19 2 1.35E-20 0.04
2 SGTC_3056 9094900 5.57 49.5 µM 5.96E-8 2 1.30E-8 0.62
3 SGTC_1050 3232-1156 5.48 69.3 µM 9.49E-8 RSC complex & mRNA processing 12 2.17E-8 0.36
4 SGTC_2985 9022375 5.04 71.4 µM 8.12E-7 RPP1 & pyrimidine depletion 3 2.34E-7 0.28
5 SGTC_93 0109-0045 4.86 59.2 µM 1.86E-6 DNA damage response 10 5.86E-7 0.30
6 SGTC_682 0kpi-0099 4.52 17.0 µM 8.47E-6 23 3.14E-6 0.06
7 SGTC_162 k030-0015 4.49 37.8 µM 9.58E-6 iron homeostasis 3 3.60E-6 0.02
8 SGTC_762 1165-0429 4.48 115.0 µM 9.91E-6 TSC3-RPN4 4 3.74E-6 0.90
9 SGTC_1983 st071813 4.38 46.9 µM 1.50E-5 RPP1 & pyrimidine depletion 3 5.91E-6 0.01
10 SGTC_572 0960-0087 4.34 17.7 µM 1.81E-5 9 7.28E-6 0.12
11 SGTC_3272 9137413 4.16 49.5 µM 3.70E-5 4 1.60E-5 0.25
12 SGTC_3271 9137798 4.11 49.5 µM 4.53E-5 3 2.00E-5 0.64
13 SGTC_2348 9022543 4.08 33.4 µM 4.98E-5 mitochondrial processes 30 2.22E-5 0.14
14 SGTC_2260 7964312 4.07 200.0 µM 5.28E-5 4 2.37E-5 0.17
15 SGTC_878 0828-0289 3.98 13.7 µM 7.53E-5 20 3.51E-5 0.02
16 SGTC_2594 a-mangostin 3.91 100.0 µM 9.65E-5 8 4.62E-5 0.21
17 SGTC_119 0121-0043 3.79 24.8 µM 1.51E-4 mitochondrial stress 27 7.56E-5 0.02
18 SGTC_2060 5238662 3.74 140.0 µM 1.83E-4 5 9.35E-5 0.18
19 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.68 100.0 µM 2.24E-4 9 1.17E-4 0.01
20 SGTC_81 0411-0046 3.67 10.0 µM 2.29E-4 43 1.20E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.288 3.61E-65 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.240 4.96E-45 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.221 2.87E-38 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.194 8.11E-30 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.180 8.28E-26 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.174 3.75E-24 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.169 5.44E-23 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.163 2.21E-21 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.157 7.07E-20 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.154 2.92E-19 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.153 4.49E-19 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.150 2.02E-18 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.149 3.65E-18 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.146 2.15E-17 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.142 1.62E-16 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene