YDL093W / PMT5

Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL093W / PMT5

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-3.71|P-value:1.22E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:4.69|P-value:1.97E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.91|P-value:6.03E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:5.22|P-value:1.33E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.49|P-value:2.99E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.80|P-value:9.40E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.50|P-value:2.85E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.24|P-value:7.18E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.23|P-value:3.75E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.44|P-value:3.75E-8 ID:SGTC_1722|Compound:st034304|FD-Score:3.40|P-value:4.16E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_1972|Compound:st070201|FD-Score:-3.54|P-value:2.30E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-4.85|P-value:7.95E-7 ID:SGTC_2004|Compound:4023728|FD-Score:-3.13|P-value:9.81E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.46|P-value:3.33E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.14|P-value:9.46E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.59|P-value:2.03E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.34|P-value:5.11E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.27|P-value:6.08E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.20|P-value:8.23E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.31|P-value:5.16E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.55|P-value:2.23E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.14|P-value:9.30E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.58|P-value:2.14E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.56|P-value:2.28E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-4.88|P-value:6.83E-7 ID:SGTC_3344|Compound:9148862|FD-Score:3.74|P-value:1.15E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.21|P-value:1.53E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.71|P-value:1.22E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:4.69|P-value:1.97E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.91|P-value:6.03E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:5.22|P-value:1.33E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.49|P-value:2.99E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.80|P-value:9.40E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.50|P-value:2.85E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.24|P-value:7.18E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.23|P-value:3.75E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.44|P-value:3.75E-8 ID:SGTC_1722|Compound:st034304|FD-Score:3.40|P-value:4.16E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_1972|Compound:st070201|FD-Score:-3.54|P-value:2.30E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-4.85|P-value:7.95E-7 ID:SGTC_2004|Compound:4023728|FD-Score:-3.13|P-value:9.81E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.46|P-value:3.33E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.14|P-value:9.46E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.59|P-value:2.03E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.34|P-value:5.11E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.27|P-value:6.08E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.20|P-value:8.23E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.31|P-value:5.16E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.55|P-value:2.23E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.14|P-value:9.30E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.58|P-value:2.14E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.56|P-value:2.28E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-4.88|P-value:6.83E-7 ID:SGTC_3344|Compound:9148862|FD-Score:3.74|P-value:1.15E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.21|P-value:1.53E-5

Top fitness defect scores for YDL093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_530 4358-1714 5.22 28.0 µM 1.33E-7 13 8.71E-8
2 SGTC_374 0880-0231 4.69 82.3 µM 1.97E-6 iron homeostasis 13 1.39E-6
3 SGTC_480 am 92016 3.91 50.0 µM 6.03E-5 14 4.67E-5
4 SGTC_696 1560-0013 3.80 611.0 µM 9.40E-5 26 7.37E-5
5 SGTC_2942 9052777 3.77 62.2 µM 1.06E-4 38 8.30E-5
6 SGTC_3344 9148862 3.74 3.9 µM 1.15E-4 16 9.08E-5
7 SGTC_3156 9099931 3.72 49.5 µM 1.25E-4 13 9.87E-5
8 SGTC_3302 9125395 3.65 16.4 µM 1.67E-4 21 1.33E-4
9 SGTC_2284 7945075 3.59 39.2 µM 2.03E-4 mitochondrial processes 36 1.62E-4
10 SGTC_3286 9117135 3.58 37.2 µM 2.14E-4 23 1.71E-4
11 SGTC_3290 9121031 3.56 71.4 µM 2.28E-4 22 1.83E-4
12 SGTC_771 0250-0039 3.53 27.3 µM 2.55E-4 23 2.05E-4
13 SGTC_741 4582-0002 3.50 126.0 µM 2.85E-4 19 2.31E-4
14 SGTC_538 2922-0838 3.49 53.3 µM 2.99E-4 Golgi 46 2.42E-4
15 SGTC_2051 5263410 3.46 176.0 µM 3.33E-4 30 2.71E-4
16 SGTC_1722 st034304 3.40 3.6 µM 4.16E-4 mitochondrial processes 48 3.40E-4
17 SGTC_1842 st055362 3.36 61.2 µM 4.81E-4 29 3.95E-4
18 SGTC_2287 7945887 3.34 168.8 µM 5.11E-4 14 4.20E-4
19 SGTC_752 1896-0090 3.24 130.0 µM 7.18E-4 TSC3-RPN4 33 5.96E-4
20 SGTC_2359 9039622 3.20 200.0 µM 8.23E-4 endomembrane recycling 54 6.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 7.83E-48 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.244 1.29E-46 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.234 1.10E-42 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.223 7.00E-39 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.212 1.82E-35 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.211 3.54E-35 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.208 5.13E-34 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.206 1.33E-33 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.205 4.85E-33 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.205 4.79E-33 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.196 2.02E-30 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.196 2.05E-30 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.195 3.67E-30 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.194 7.29E-30 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.189 2.44E-28 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication