YDL094C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL094C / YDL094C

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.75|P-value:4.88E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.31|P-value:2.96E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.57|P-value:7.28E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.30|P-value:2.21E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.98|P-value:1.20E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.13|P-value:5.78E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.80|P-value:2.71E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.69|P-value:6.18E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.09|P-value:5.08E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.19|P-value:3.44E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.28|P-value:2.42E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.10|P-value:6.48E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.94|P-value:8.38E-8 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.65|P-value:5.35E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.04|P-value:8.15E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.91|P-value:9.73E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.22|P-value:3.80E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.02|P-value:8.75E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.04|P-value:8.02E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.80|P-value:3.86E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.07|P-value:7.20E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.19|P-value:3.45E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.67|P-value:4.78E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:2.97|P-value:7.89E-4 ID:SGTC_1728|Compound:st035614|FD-Score:2.91|P-value:9.66E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-5.20|P-value:2.92E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.64|P-value:5.42E-5 ID:SGTC_1803|Compound:st050068|FD-Score:2.98|P-value:7.62E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.18|P-value:6.64E-6 ID:SGTC_1941|Compound:st076221|FD-Score:2.98|P-value:7.57E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.95|P-value:8.38E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.55|P-value:7.05E-7 ID:SGTC_2082|Compound:5219693|FD-Score:-3.45|P-value:1.68E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.25|P-value:3.74E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.92|P-value:2.22E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.36|P-value:1.88E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.25|P-value:3.67E-4 ID:SGTC_2709|Compound:st078560|FD-Score:2.94|P-value:8.81E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.57|P-value:1.04E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.92|P-value:2.26E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.10|P-value:6.37E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-4.15|P-value:7.74E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.18|P-value:6.64E-6 ID:SGTC_3020|Compound:9089140|FD-Score:-4.89|P-value:1.69E-7 ID:SGTC_3032|Compound:9089427|FD-Score:3.15|P-value:3.96E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.03|P-value:8.41E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.11|P-value:6.33E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.93|P-value:1.51E-5 ID:SGTC_3242|Compound:9133940|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_3286|Compound:9117135|FD-Score:2.96|P-value:7.98E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.75|P-value:4.88E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.31|P-value:2.96E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.57|P-value:7.28E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.30|P-value:2.21E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.98|P-value:1.20E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.13|P-value:5.78E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.80|P-value:2.71E-5 ID:SGTC_489|Compound:paxilline|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.69|P-value:6.18E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.09|P-value:5.08E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.19|P-value:3.44E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.28|P-value:2.42E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.10|P-value:6.48E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.94|P-value:8.38E-8 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.65|P-value:5.35E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.04|P-value:8.15E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.91|P-value:9.73E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.22|P-value:3.80E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.02|P-value:8.75E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.04|P-value:8.02E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.80|P-value:3.86E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.07|P-value:7.20E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.19|P-value:3.45E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.67|P-value:4.78E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:2.97|P-value:7.89E-4 ID:SGTC_1728|Compound:st035614|FD-Score:2.91|P-value:9.66E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-5.20|P-value:2.92E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.64|P-value:5.42E-5 ID:SGTC_1803|Compound:st050068|FD-Score:2.98|P-value:7.62E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.18|P-value:6.64E-6 ID:SGTC_1941|Compound:st076221|FD-Score:2.98|P-value:7.57E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.95|P-value:8.38E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.55|P-value:7.05E-7 ID:SGTC_2082|Compound:5219693|FD-Score:-3.45|P-value:1.68E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.25|P-value:3.74E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.92|P-value:2.22E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.36|P-value:1.88E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.25|P-value:3.67E-4 ID:SGTC_2709|Compound:st078560|FD-Score:2.94|P-value:8.81E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.57|P-value:1.04E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.92|P-value:2.26E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.10|P-value:6.37E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-4.15|P-value:7.74E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.18|P-value:6.64E-6 ID:SGTC_3020|Compound:9089140|FD-Score:-4.89|P-value:1.69E-7 ID:SGTC_3032|Compound:9089427|FD-Score:3.15|P-value:3.96E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.03|P-value:8.41E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.11|P-value:6.33E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.93|P-value:1.51E-5 ID:SGTC_3242|Compound:9133940|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_3286|Compound:9117135|FD-Score:2.96|P-value:7.98E-4

Top fitness defect scores for YDL094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 4.94 1.8 µM 8.38E-8 58 3.95E-7
2 SGTC_2059 5238311 4.55 157.0 µM 7.05E-7 11 2.69E-6
3 SGTC_2419 paclitaxel 4.36 166.5 µM 1.88E-6 27 6.51E-6
4 SGTC_1359 1582-0056 4.22 520.0 nM 3.80E-6 14 1.23E-5
5 SGTC_396 dithiazanine 3.98 1.2 µM 1.20E-5 7 3.46E-5
6 SGTC_3224 9130643 3.93 49.5 µM 1.51E-5 RPP1 & pyrimidine depletion 28 4.25E-5
7 SGTC_470 aa-861 3.80 153.0 µM 2.71E-5 sphingolipid biosynthesis & PDR1 62 7.21E-5
8 SGTC_3249 9135183 3.73 49.5 µM 3.77E-5 60S ribosome export 14 9.73E-5
9 SGTC_1476 4112-3294 3.67 3.3 µM 4.78E-5 60S ribosome export 27 1.20E-4
10 SGTC_1030 k029-0042 3.65 36.7 µM 5.35E-5 TSC3-RPN4 37 1.33E-4
11 SGTC_1800 st050079 3.64 29.1 µM 5.42E-5 NEO1-PIK1 143 1.35E-4
12 SGTC_309 k408-0051 3.57 1.5 µM 7.28E-5 74 1.76E-4
13 SGTC_1361 1608-0041 3.48 5.6 µM 1.07E-4 RPP1 & pyrimidine depletion 30 2.49E-4
14 SGTC_2844 9010103 3.41 26.0 µM 1.42E-4 50 3.21E-4
15 SGTC_358 0075-0058 3.30 9.4 µM 2.21E-4 102 4.79E-4
16 SGTC_1021 4476-0760 3.29 85.3 µM 2.35E-4 56 5.06E-4
17 SGTC_675 1309-0189 3.28 238.0 µM 2.42E-4 27 5.20E-4
18 SGTC_3242 9133940 3.23 49.5 µM 2.97E-4 31 6.25E-4
19 SGTC_674 0498-0004 3.19 451.0 µM 3.44E-4 heme requiring 45 7.13E-4
20 SGTC_1452 4194-0072 3.19 190.0 µM 3.45E-4 41 7.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 1.22E-26 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.153 4.72E-19 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.146 2.32E-17 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.138 8.42E-16 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.136 2.91E-15 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.130 3.94E-14 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.127 1.51E-13 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.126 2.54E-13 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.121 1.90E-12 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.119 4.44E-12 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.116 1.57E-11 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.114 3.02E-11 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.114 3.29E-11 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.112 8.20E-11 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.107 4.46E-10 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele