YDL096C_d / OPI6

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL096C / OPI6

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.49|P-value:8.73E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.49|P-value:6.43E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:2.93|P-value:8.32E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.28|P-value:2.16E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.04|P-value:3.04E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:16.30|P-value:2.54E-69 ID:SGTC_353|Compound:1988-1175|FD-Score:4.61|P-value:3.53E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:2.89|P-value:9.55E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.50|P-value:8.35E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.86|P-value:7.83E-14 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.56|P-value:6.19E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:6.27|P-value:7.84E-12 ID:SGTC_663|Compound:1486-0733|FD-Score:4.83|P-value:1.04E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:7.17|P-value:6.53E-15 ID:SGTC_758|Compound:0868-0029|FD-Score:3.86|P-value:1.67E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.20|P-value:2.96E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.99|P-value:9.14E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:8.95|P-value:3.05E-22 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.92|P-value:5.79E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:2.88|P-value:9.79E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.07|P-value:4.88E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.85|P-value:1.80E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.37|P-value:1.41E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.89|P-value:9.58E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.01|P-value:6.23E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.58|P-value:6.09E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.48|P-value:9.24E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.58|P-value:6.00E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.39|P-value:1.38E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-2.98|P-value:6.46E-4 ID:SGTC_2207|Compound:7258803|FD-Score:2.97|P-value:7.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.02|P-value:5.62E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.41|P-value:1.25E-4 ID:SGTC_2289|Compound:7946404|FD-Score:8.34|P-value:1.56E-19 ID:SGTC_2399|Compound:5884133|FD-Score:4.21|P-value:3.05E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.43|P-value:1.09E-4 ID:SGTC_2413|Compound:inermin|FD-Score:12.50|P-value:7.99E-42 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.84|P-value:8.99E-8 ID:SGTC_2602|Compound:kawain|FD-Score:5.13|P-value:1.74E-8 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.98|P-value:9.32E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.88|P-value:7.04E-8 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.78|P-value:2.29E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:-5.24|P-value:8.31E-9 ID:SGTC_2731|Compound:amoxapine|FD-Score:-3.09|P-value:4.30E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:-3.92|P-value:1.18E-5 ID:SGTC_2734|Compound:clemastine|FD-Score:-3.26|P-value:2.14E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.04|P-value:5.59E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.36|P-value:1.54E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.25|P-value:2.28E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.31|P-value:1.75E-4 ID:SGTC_2997|Compound:9067075|FD-Score:2.90|P-value:9.30E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.49|P-value:8.73E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.49|P-value:6.43E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:2.93|P-value:8.32E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.28|P-value:2.16E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.04|P-value:3.04E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:16.30|P-value:2.54E-69 ID:SGTC_353|Compound:1988-1175|FD-Score:4.61|P-value:3.53E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:2.89|P-value:9.55E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.50|P-value:8.35E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.86|P-value:7.83E-14 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.56|P-value:6.19E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:6.27|P-value:7.84E-12 ID:SGTC_663|Compound:1486-0733|FD-Score:4.83|P-value:1.04E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:7.17|P-value:6.53E-15 ID:SGTC_758|Compound:0868-0029|FD-Score:3.86|P-value:1.67E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.20|P-value:2.96E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.99|P-value:9.14E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:8.95|P-value:3.05E-22 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.92|P-value:5.79E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:2.88|P-value:9.79E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.07|P-value:4.88E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.85|P-value:1.80E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.37|P-value:1.41E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.89|P-value:9.58E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.01|P-value:6.23E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.58|P-value:6.09E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.48|P-value:9.24E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.58|P-value:6.00E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.39|P-value:1.38E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-2.98|P-value:6.46E-4 ID:SGTC_2207|Compound:7258803|FD-Score:2.97|P-value:7.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.02|P-value:5.62E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.41|P-value:1.25E-4 ID:SGTC_2289|Compound:7946404|FD-Score:8.34|P-value:1.56E-19 ID:SGTC_2399|Compound:5884133|FD-Score:4.21|P-value:3.05E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.43|P-value:1.09E-4 ID:SGTC_2413|Compound:inermin|FD-Score:12.50|P-value:7.99E-42 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.84|P-value:8.99E-8 ID:SGTC_2602|Compound:kawain|FD-Score:5.13|P-value:1.74E-8 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.98|P-value:9.32E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.88|P-value:7.04E-8 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.78|P-value:2.29E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:-5.24|P-value:8.31E-9 ID:SGTC_2731|Compound:amoxapine|FD-Score:-3.09|P-value:4.30E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:-3.92|P-value:1.18E-5 ID:SGTC_2734|Compound:clemastine|FD-Score:-3.26|P-value:2.14E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.04|P-value:5.59E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.36|P-value:1.54E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.25|P-value:2.28E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.31|P-value:1.75E-4 ID:SGTC_2997|Compound:9067075|FD-Score:2.90|P-value:9.30E-4

Top fitness defect scores for YDL096C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_143 4032-1194 16.30 15.7 µM 2.54E-69 2 3.56E-60
2 SGTC_2413 inermin 12.50 26.1 µM 7.99E-42 3 2.05E-36
3 SGTC_800 3448-7362 8.95 155.0 µM 3.05E-22 translation 12 1.75E-19
4 SGTC_2289 7946404 8.34 165.1 µM 1.56E-19 14 3.85E-17
5 SGTC_708 3448-5400 7.17 146.0 µM 6.53E-15 6 3.87E-13
6 SGTC_453 enantio-paf c16 6.86 10.0 µM 7.83E-14 27 3.33E-12
7 SGTC_531 3788-1495 6.27 174.0 µM 7.84E-12 unfolded protein response 8 1.80E-10
8 SGTC_2602 kawain 5.13 100.0 µM 1.74E-8 8 1.44E-7
9 SGTC_117 lucigenin 5.04 22.1 µM 3.04E-8 redox potentiating 59 2.34E-7
10 SGTC_663 1486-0733 4.83 13.9 µM 1.04E-7 cell wall signaling 34 6.78E-7
11 SGTC_353 1988-1175 4.61 58.3 µM 3.53E-7 unfolded protein response 15 1.97E-6
12 SGTC_2399 5884133 4.21 200.0 µM 3.05E-6 cell wall signaling 62 1.28E-5
13 SGTC_786 4544-0069 3.99 423.0 µM 9.14E-6 24 3.33E-5
14 SGTC_2724 maprotiline 3.98 69.6 µM 9.32E-6 ERG2 15 3.39E-5
15 SGTC_758 0868-0029 3.86 16.0 µM 1.67E-5 6 5.63E-5
16 SGTC_1687 st020778 3.85 55.4 µM 1.80E-5 181 6.01E-5
17 SGTC_2119 5528445 3.58 120.6 µM 6.00E-5 34 1.71E-4
18 SGTC_2007 4011539 3.58 71.8 µM 6.09E-5 cell wall signaling 81 1.74E-4
19 SGTC_410 α-linolenic acid 3.50 100.0 µM 8.35E-5 excess fatty acid 50 2.29E-4
20 SGTC_22 0964-0034 3.49 14.5 µM 8.73E-5 unfolded protein response 62 2.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.395 4.03E-125 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.345 2.11E-94 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.297 5.93E-69 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.290 7.43E-66 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.284 1.92E-63 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.283 7.89E-63 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.273 3.43E-58 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.265 6.53E-55 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.251 3.85E-49 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.232 4.27E-42 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.207 6.68E-34 YJL139C YUR1 hom Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication
0.206 1.35E-33 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.206 2.27E-33 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.199 3.97E-31 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.190 1.71E-28 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response