YDL098C / SNU23

Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL098C / SNU23

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.14|P-value:1.13E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.12|P-value:6.12E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.03|P-value:9.91E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.29|P-value:3.25E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.42|P-value:1.97E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.35|P-value:3.09E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.27|P-value:3.46E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.90|P-value:3.27E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.75|P-value:6.29E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.16|P-value:1.02E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.06|P-value:7.64E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.24|P-value:7.12E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.16|P-value:6.18E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.70|P-value:7.82E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.56|P-value:1.34E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.25|P-value:4.49E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-4.68|P-value:6.58E-7 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.12|P-value:7.29E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.70|P-value:7.67E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.25|P-value:4.40E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:4.29|P-value:5.58E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-5.39|P-value:1.25E-8 ID:SGTC_1744|Compound:st037937|FD-Score:-3.00|P-value:9.43E-4 ID:SGTC_2074|Compound:5212007|FD-Score:4.66|P-value:8.87E-7 ID:SGTC_2161|Compound:5662504|FD-Score:-3.11|P-value:6.25E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.11|P-value:6.31E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.99|P-value:1.59E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.53|P-value:1.54E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.11|P-value:6.23E-4 ID:SGTC_3008|Compound:9078912|FD-Score:4.13|P-value:1.19E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.85|P-value:4.09E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-3.18|P-value:4.98E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.22|P-value:6.31E-6 ID:SGTC_3115|Compound:9123671|FD-Score:3.20|P-value:5.47E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-4.29|P-value:4.58E-6 ID:SGTC_3186|Compound:9110464|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.57|P-value:1.09E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.37|P-value:2.90E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.14|P-value:1.13E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.12|P-value:6.12E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.03|P-value:9.91E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.29|P-value:3.25E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.42|P-value:1.97E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.35|P-value:3.09E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.27|P-value:3.46E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.90|P-value:3.27E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.75|P-value:6.29E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.16|P-value:1.02E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.06|P-value:7.64E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.24|P-value:7.12E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.16|P-value:6.18E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.70|P-value:7.82E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.56|P-value:1.34E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.25|P-value:4.49E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-4.68|P-value:6.58E-7 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.12|P-value:7.29E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.70|P-value:7.67E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.25|P-value:4.40E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:4.29|P-value:5.58E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-5.39|P-value:1.25E-8 ID:SGTC_1744|Compound:st037937|FD-Score:-3.00|P-value:9.43E-4 ID:SGTC_2074|Compound:5212007|FD-Score:4.66|P-value:8.87E-7 ID:SGTC_2161|Compound:5662504|FD-Score:-3.11|P-value:6.25E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.11|P-value:6.31E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.99|P-value:1.59E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.53|P-value:1.54E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.11|P-value:6.23E-4 ID:SGTC_3008|Compound:9078912|FD-Score:4.13|P-value:1.19E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.85|P-value:4.09E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-3.18|P-value:4.98E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.22|P-value:6.31E-6 ID:SGTC_3115|Compound:9123671|FD-Score:3.20|P-value:5.47E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-4.29|P-value:4.58E-6 ID:SGTC_3186|Compound:9110464|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.57|P-value:1.09E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.37|P-value:2.90E-4

Top fitness defect scores for YDL098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2520 obtusaquinone 4.99 4.7 µM 1.59E-7 1 3.02E-7 0.79
2 SGTC_2074 5212007 4.66 75.4 µM 8.87E-7 1 1.55E-6 0.85
3 SGTC_1486 3970-0793 4.29 4.5 µM 5.58E-6 1 8.89E-6 0.43
4 SGTC_1030 k029-0042 4.24 36.7 µM 7.12E-6 TSC3-RPN4 2 1.12E-5 0.25
5 SGTC_871 0574-0004 4.16 149.0 µM 1.02E-5 26 1.58E-5 0.30
6 SGTC_14 0354-0009 4.14 295.0 µM 1.13E-5 1 1.73E-5 0.30
7 SGTC_3008 9078912 4.13 71.4 µM 1.19E-5 2 1.82E-5 0.37
8 SGTC_2514 salinomycin 4.05 42.7 µM 1.71E-5 1 2.57E-5 0.28
9 SGTC_2607 solasodine 4.00 47.4 µM 2.11E-5 11 3.14E-5 0.12
10 SGTC_642 0335-0876 3.90 158.0 µM 3.27E-5 ubiquinone biosynthesis & proteasome 10 4.77E-5 0.13
11 SGTC_3014 9081533 3.85 49.5 µM 4.09E-5 4 5.91E-5 0.24
12 SGTC_796 1234-0020 3.75 70.7 µM 6.29E-5 SWF1 & branched chain AA biosynthesis 7 8.90E-5 0.03
13 SGTC_1477 0139-0234 3.70 16.0 µM 7.67E-5 4 1.08E-4 0.39
14 SGTC_1187 1391-0724 3.70 117.0 µM 7.82E-5 amide catabolism 5 1.10E-4 0.19
15 SGTC_1311 1190-0148 3.63 100.0 µM 1.01E-4 azole & statin 10 1.40E-4 0.04
16 SGTC_1245 0418-0076 3.60 17.2 µM 1.14E-4 ERG2 11 1.56E-4 0.06
17 SGTC_1325 1431-0015 3.56 227.0 µM 1.34E-4 Golgi 5 1.82E-4 0.07
18 SGTC_2560 caryophyllene 3.53 100.0 µM 1.54E-4 10 2.09E-4 0.04
19 SGTC_3103 9120822 3.44 49.5 µM 2.19E-4 12 2.92E-4 1.26E-4
20 SGTC_3325 9138760 3.37 55.2 µM 2.90E-4 Golgi 8 3.82E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 2.04E-14 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.119 4.05E-12 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
0.101 4.91E-9 YCR095W-A_p YCR095W-A_p hom Putative protein of unknown function
0.092 9.05E-8 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.085 7.78E-7 YLR164W SHH4 hom Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
0.085 8.81E-7 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.084 1.04E-6 YDL034W_d YDL034W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene
0.081 2.34E-6 YMR174C PAI3 hom Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
0.079 4.08E-6 YLR377C FBP1 hom Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p
0.076 1.12E-5 YOL153C YOL153C hom Hypothetical protein
0.073 2.15E-5 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.073 2.43E-5 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.071 3.58E-5 YPL135W ISU1 hom Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
0.071 3.74E-5 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.070 4.85E-5 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response