YDL102W / POL3

Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL102W / POL3

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:3.39|P-value:3.95E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:4.55|P-value:3.26E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.05|P-value:2.92E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.67|P-value:1.88E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:5.23|P-value:1.11E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:5.12|P-value:1.97E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:6.10|P-value:7.50E-10 ID:SGTC_174|Compound:3553-0389|FD-Score:3.81|P-value:8.29E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:4.25|P-value:1.30E-5 ID:SGTC_264|Compound:promethazine|FD-Score:6.62|P-value:2.69E-11 ID:SGTC_363|Compound:0455-0021|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.98|P-value:4.07E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.28|P-value:1.11E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:5.29|P-value:7.99E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.87|P-value:6.42E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.98|P-value:3.90E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.73|P-value:1.07E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.35|P-value:4.52E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:6.12|P-value:6.86E-10 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:-3.43|P-value:3.25E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.85|P-value:3.55E-9 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.27|P-value:5.75E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.25|P-value:6.42E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.23|P-value:6.92E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.22|P-value:6.94E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.57|P-value:2.89E-6 ID:SGTC_2181|Compound:6316240|FD-Score:-4.23|P-value:1.30E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.47|P-value:3.00E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.91|P-value:5.44E-5 ID:SGTC_2388|Compound:9080168|FD-Score:4.79|P-value:1.03E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-3.13|P-value:9.21E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.15|P-value:9.10E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.98|P-value:3.92E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.14|P-value:9.60E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.13|P-value:9.90E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.95|P-value:4.26E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.96|P-value:4.36E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-8.65|P-value:4.54E-18 ID:SGTC_2996|Compound:9066192|FD-Score:3.81|P-value:8.25E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-4.29|P-value:1.03E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.88|P-value:2.96E-9 ID:SGTC_3167|Compound:9103034|FD-Score:4.00|P-value:3.71E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.82|P-value:7.83E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.65|P-value:1.92E-6 ID:SGTC_3278|Compound:9139605|FD-Score:-4.85|P-value:7.30E-7 ID:SGTC_3290|Compound:9121031|FD-Score:3.39|P-value:3.95E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.93|P-value:5.04E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:3.39|P-value:3.95E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:4.55|P-value:3.26E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.05|P-value:2.92E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.67|P-value:1.88E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:5.23|P-value:1.11E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:5.12|P-value:1.97E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:6.10|P-value:7.50E-10 ID:SGTC_174|Compound:3553-0389|FD-Score:3.81|P-value:8.29E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:4.25|P-value:1.30E-5 ID:SGTC_264|Compound:promethazine|FD-Score:6.62|P-value:2.69E-11 ID:SGTC_363|Compound:0455-0021|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.98|P-value:4.07E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.28|P-value:1.11E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:5.29|P-value:7.99E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.87|P-value:6.42E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.98|P-value:3.90E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.73|P-value:1.07E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.35|P-value:4.52E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:6.12|P-value:6.86E-10 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:-3.43|P-value:3.25E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.85|P-value:3.55E-9 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.27|P-value:5.75E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.25|P-value:6.42E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.23|P-value:6.92E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.22|P-value:6.94E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.57|P-value:2.89E-6 ID:SGTC_2181|Compound:6316240|FD-Score:-4.23|P-value:1.30E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.47|P-value:3.00E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.91|P-value:5.44E-5 ID:SGTC_2388|Compound:9080168|FD-Score:4.79|P-value:1.03E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-3.13|P-value:9.21E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.15|P-value:9.10E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.98|P-value:3.92E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.14|P-value:9.60E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.13|P-value:9.90E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.95|P-value:4.26E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.96|P-value:4.36E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-8.65|P-value:4.54E-18 ID:SGTC_2996|Compound:9066192|FD-Score:3.81|P-value:8.25E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-4.29|P-value:1.03E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.88|P-value:2.96E-9 ID:SGTC_3167|Compound:9103034|FD-Score:4.00|P-value:3.71E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.82|P-value:7.83E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.65|P-value:1.92E-6 ID:SGTC_3278|Compound:9139605|FD-Score:-4.85|P-value:7.30E-7 ID:SGTC_3290|Compound:9121031|FD-Score:3.39|P-value:3.95E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.93|P-value:5.04E-5

Top fitness defect scores for YDL102W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_264 promethazine 6.62 12.5 mM 2.69E-11 DNA intercalators 9 1.76E-11 0.95
2 SGTC_1468 k284-1086 6.12 134.0 µM 6.86E-10 DNA intercalators 4 4.76E-10 0.42
3 SGTC_145 3737-0113 6.10 38.4 µM 7.50E-10 DNA intercalators 17 5.20E-10 0.06
4 SGTC_3126 9127922 5.88 49.5 µM 2.96E-9 fatty acid desaturase (OLE1) 10 2.11E-9 0.08
5 SGTC_1515 3460-0031 5.85 42.1 µM 3.55E-9 DNA intercalators 4 2.53E-9 1.57
6 SGTC_844 0330-0132 5.29 15.3 µM 7.99E-8 2 6.02E-8 0.43
7 SGTC_126 0417-1624 5.23 672.5 µM 1.11E-7 DNA intercalators 7 8.45E-8 0.06
8 SGTC_144 4161-2749 5.12 112.4 µM 1.97E-7 DNA intercalators 6 1.51E-7 0.28
9 SGTC_2388 9080168 4.79 200.0 µM 1.03E-6 1 8.14E-7 0.76
10 SGTC_119 0121-0043 4.67 24.8 µM 1.88E-6 mitochondrial stress 12 1.50E-6 0.18
11 SGTC_112 phenothiazine 4.55 287.2 µM 3.26E-6 unfolded protein response 3 2.63E-6 0.26
12 SGTC_450 aminopyrene 4.28 156.0 nM 1.11E-5 5 9.15E-6 0.09
13 SGTC_175 3793-3120 4.25 23.7 µM 1.30E-5 2 1.07E-5 0.20
14 SGTC_3167 9103034 4.00 49.5 µM 3.71E-5 RPP1 & pyrimidine depletion 4 3.12E-5 0.11
15 SGTC_364 0083-0097 3.98 67.7 µM 4.07E-5 9 3.43E-5 0.32
16 SGTC_2883 9059145 3.96 45.5 µM 4.36E-5 5 3.68E-5 0.20
17 SGTC_3326 9140064 3.93 16.4 µM 5.04E-5 6 4.27E-5 0.36
18 SGTC_2362 9071156 3.91 126.0 µM 5.44E-5 4 4.61E-5 0.28
19 SGTC_917 harmaline 3.87 728.1 nM 6.42E-5 ergosterol biosynthesis 10 5.46E-5 0.29
20 SGTC_3210 9128157 3.82 49.5 µM 7.83E-5 15 6.67E-5 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 3.52E-61 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.274 8.49E-59 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.262 6.78E-54 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.246 2.61E-47 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.239 6.06E-45 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.237 5.99E-44 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.232 2.45E-42 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.232 2.97E-42 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.230 1.82E-41 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.211 5.25E-35 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.198 6.96E-31 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.176 1.41E-24 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.171 1.90E-23 YDR054C CDC34 het Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.167 2.28E-22 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.160 1.36E-20 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism