YDL103C / QRI1

UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL103C / QRI1

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:3.31|P-value:9.70E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.60|P-value:3.81E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.97|P-value:1.49E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.95|P-value:1.63E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:3.45|P-value:6.27E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.83|P-value:1.58E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.38|P-value:7.84E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.96|P-value:1.06E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.55|P-value:4.17E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.31|P-value:9.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.51|P-value:4.69E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-4.67|P-value:5.63E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.49|P-value:5.04E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.47|P-value:1.41E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.40|P-value:7.29E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.33|P-value:9.18E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.39|P-value:7.15E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.48|P-value:5.71E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.80|P-value:1.88E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.38|P-value:7.98E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.31|P-value:9.93E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.32|P-value:9.55E-4 ID:SGTC_2425|Compound:5628681|FD-Score:5.98|P-value:1.04E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-3.92|P-value:1.11E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.96|P-value:9.80E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.56|P-value:9.54E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:3.73|P-value:2.45E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:6.34|P-value:1.40E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.79|P-value:1.92E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.80|P-value:1.85E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.98|P-value:9.07E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.33|P-value:9.17E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-4.50|P-value:1.15E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.63|P-value:3.46E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.74|P-value:2.11E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.79|P-value:1.78E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.77|P-value:2.13E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.31|P-value:9.70E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.60|P-value:3.81E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.97|P-value:1.49E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.95|P-value:1.63E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:3.45|P-value:6.27E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.83|P-value:1.58E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.38|P-value:7.84E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.96|P-value:1.06E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.55|P-value:4.17E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.31|P-value:9.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.51|P-value:4.69E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-4.67|P-value:5.63E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.49|P-value:5.04E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.47|P-value:1.41E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.40|P-value:7.29E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.33|P-value:9.18E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.39|P-value:7.15E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.48|P-value:5.71E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.80|P-value:1.88E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.38|P-value:7.98E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.31|P-value:9.93E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.32|P-value:9.55E-4 ID:SGTC_2425|Compound:5628681|FD-Score:5.98|P-value:1.04E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-3.92|P-value:1.11E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.96|P-value:9.80E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.56|P-value:9.54E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:3.73|P-value:2.45E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:6.34|P-value:1.40E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.79|P-value:1.92E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.80|P-value:1.85E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.98|P-value:9.07E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.33|P-value:9.17E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-4.50|P-value:1.15E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.63|P-value:3.46E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.74|P-value:2.11E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.79|P-value:1.78E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.77|P-value:2.13E-4

Top fitness defect scores for YDL103C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2608 thymoquinone 6.34 42.7 µM 1.40E-9 1 1.12E-10 1.40
2 SGTC_2425 5628681 5.98 7.8 µM 1.04E-8 1 1.09E-9 0.94
3 SGTC_2604 4'-hydroxychalcone 5.56 11.3 µM 9.54E-8 5 1.34E-8 0.68
4 SGTC_1359 1582-0056 4.47 520.0 nM 1.41E-5 3 3.84E-6 0.60
5 SGTC_986 1493-0483 3.96 84.0 µM 1.06E-4 3 3.76E-5 0.26
6 SGTC_2681 menadione 3.80 3.2 µM 1.85E-4 superoxide 5 7.09E-5 0.02
7 SGTC_2076 5212012 3.80 200.0 µM 1.88E-4 1 7.22E-5 0.37
8 SGTC_2639 lactacystin 3.79 53.0 µM 1.92E-4 10 7.39E-5 0.05
9 SGTC_3103 9120822 3.77 49.5 µM 2.13E-4 9 8.31E-5 0.01
10 SGTC_2605 digitonin 3.73 300.0 nM 2.45E-4 5 9.72E-5 0.11
11 SGTC_2874 9043904 3.63 71.4 µM 3.46E-4 3 1.44E-4 0.23
12 SGTC_286 k060-0067 3.60 22.9 µM 3.81E-4 tubulin folding & SWR complex 10 1.60E-4 0.02
13 SGTC_2458 5808907 3.59 16.4 µM 3.95E-4 7 1.67E-4 0.16
14 SGTC_2014 4013930 3.48 200.0 µM 5.71E-4 7 2.53E-4 0.10
15 SGTC_794 k038-0031 3.45 316.0 µM 6.27E-4 ubiquinone biosynthesis & proteasome 26 2.81E-4 0.01
16 SGTC_1104 tacrolimus 3.43 29.8 µM 6.68E-4 12 3.02E-4 0.02
17 SGTC_1395 3486-0190 3.40 4.3 µM 7.29E-4 5 3.34E-4 0.17
18 SGTC_966 1300-0360 3.38 30.2 µM 7.84E-4 heme requiring 25 3.62E-4 0.24
19 SGTC_2284 7945075 3.38 39.2 µM 7.98E-4 mitochondrial processes 3 3.69E-4 0.03
20 SGTC_2794 7785382 3.33 27.3 µM 9.17E-4 22 4.32E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.30E-14 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.115 2.55E-11 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.106 6.54E-10 YOL119C MCH4 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.105 9.77E-10 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.101 4.71E-9 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.095 3.11E-8 YDR146C SWI5 hom Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.093 6.32E-8 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.092 9.72E-8 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.090 1.61E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.088 3.51E-7 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.085 8.56E-7 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.49E-6 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.081 2.32E-6 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.080 3.32E-6 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.079 4.07E-6 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3