YDL111C / RRP42

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL111C / RRP42

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.11|P-value:8.09E-5 ID:SGTC_215|Compound:1287-0124|FD-Score:3.42|P-value:8.52E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:9.40|P-value:2.91E-18 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:6.85|P-value:1.51E-10 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:10.10|P-value:9.34E-21 ID:SGTC_459|Compound:nigericin|FD-Score:-4.03|P-value:1.00E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:8.80|P-value:3.12E-16 ID:SGTC_617|Compound:3770-0098|FD-Score:7.57|P-value:1.70E-12 ID:SGTC_879|Compound:0831-1030|FD-Score:4.68|P-value:8.49E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:5.90|P-value:2.92E-8 ID:SGTC_984|Compound:1492-0255|FD-Score:4.78|P-value:5.57E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:9.29|P-value:6.75E-18 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:13.10|P-value:9.84E-34 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.56|P-value:1.39E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.21|P-value:5.63E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.39|P-value:9.01E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.91|P-value:1.66E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.39|P-value:9.22E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.55|P-value:5.30E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:14.70|P-value:3.89E-42 ID:SGTC_1744|Compound:st037937|FD-Score:-3.39|P-value:8.76E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.42|P-value:8.40E-4 ID:SGTC_1887|Compound:st057648|FD-Score:5.07|P-value:1.59E-6 ID:SGTC_1948|Compound:st076329|FD-Score:-3.40|P-value:8.63E-4 ID:SGTC_2053|Compound:5265679|FD-Score:5.09|P-value:1.45E-6 ID:SGTC_2239|Compound:6685329|FD-Score:3.44|P-value:7.92E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.84|P-value:1.97E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.07|P-value:8.76E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.42|P-value:8.54E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-5.93|P-value:2.40E-8 ID:SGTC_3148|Compound:9097893|FD-Score:4.06|P-value:9.75E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.46|P-value:7.43E-4 ID:SGTC_3205|Compound:9113483|FD-Score:5.05|P-value:1.75E-6 ID:SGTC_3213|Compound:9129884|FD-Score:3.49|P-value:6.82E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.44|P-value:7.89E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.73|P-value:6.87E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-3.54|P-value:5.46E-4 ID:SGTC_3337|Compound:9144342|FD-Score:7.25|P-value:1.37E-11 ID:SGTC_118|Compound:0083-0097|FD-Score:4.11|P-value:8.09E-5 ID:SGTC_215|Compound:1287-0124|FD-Score:3.42|P-value:8.52E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:9.40|P-value:2.91E-18 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:6.85|P-value:1.51E-10 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:10.10|P-value:9.34E-21 ID:SGTC_459|Compound:nigericin|FD-Score:-4.03|P-value:1.00E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:8.80|P-value:3.12E-16 ID:SGTC_617|Compound:3770-0098|FD-Score:7.57|P-value:1.70E-12 ID:SGTC_879|Compound:0831-1030|FD-Score:4.68|P-value:8.49E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:5.90|P-value:2.92E-8 ID:SGTC_984|Compound:1492-0255|FD-Score:4.78|P-value:5.57E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:9.29|P-value:6.75E-18 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:13.10|P-value:9.84E-34 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.56|P-value:1.39E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.21|P-value:5.63E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.39|P-value:9.01E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.91|P-value:1.66E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.39|P-value:9.22E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.55|P-value:5.30E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:14.70|P-value:3.89E-42 ID:SGTC_1744|Compound:st037937|FD-Score:-3.39|P-value:8.76E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.42|P-value:8.40E-4 ID:SGTC_1887|Compound:st057648|FD-Score:5.07|P-value:1.59E-6 ID:SGTC_1948|Compound:st076329|FD-Score:-3.40|P-value:8.63E-4 ID:SGTC_2053|Compound:5265679|FD-Score:5.09|P-value:1.45E-6 ID:SGTC_2239|Compound:6685329|FD-Score:3.44|P-value:7.92E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.84|P-value:1.97E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.07|P-value:8.76E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.42|P-value:8.54E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-5.93|P-value:2.40E-8 ID:SGTC_3148|Compound:9097893|FD-Score:4.06|P-value:9.75E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.46|P-value:7.43E-4 ID:SGTC_3205|Compound:9113483|FD-Score:5.05|P-value:1.75E-6 ID:SGTC_3213|Compound:9129884|FD-Score:3.49|P-value:6.82E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.44|P-value:7.89E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.73|P-value:6.87E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-3.54|P-value:5.46E-4 ID:SGTC_3337|Compound:9144342|FD-Score:7.25|P-value:1.37E-11

Top fitness defect scores for YDL111C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1698 5-fluorocytosine 14.70 1.1 µM 3.89E-42 exosome 1 1.81E-49 3.55
2 SGTC_1077 5-fluorocytosine 13.10 377.0 nM 9.84E-34 exosome 1 1.53E-39 1.07
3 SGTC_423 5-fluorouracil 10.10 457.0 µM 9.34E-21 exosome 7 3.24E-24 2.32
4 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 9.40 4.6 µM 2.91E-18 heat shock/prefoldin 6 2.85E-21 2.35
5 SGTC_1074 carmofur 9.29 3.8 µM 6.75E-18 exosome 6 7.67E-21 0.76
6 SGTC_610 4215-0184 8.80 155.0 µM 3.12E-16 exosome 5 7.08E-19 1.37
7 SGTC_617 3770-0098 7.57 35.0 µM 1.70E-12 exosome 11 1.81E-14 0.35
8 SGTC_3337 9144342 7.25 33.5 µM 1.37E-11 3 2.12E-13 1.40
9 SGTC_261 5-fluorouridine 6.85 15.4 µM 1.51E-10 exosome 3 3.59E-12 1.22
10 SGTC_976 1348-1067 5.90 47.6 µM 2.92E-8 60S ribosome export 3 1.78E-9 1.19
11 SGTC_2053 5265679 5.09 138.0 µM 1.45E-6 3 1.76E-7 0.79
12 SGTC_1887 st057648 5.07 70.8 µM 1.59E-6 1 1.96E-7 0.39
13 SGTC_3205 9113483 5.05 49.5 µM 1.75E-6 2 2.20E-7 0.40
14 SGTC_984 1492-0255 4.78 2.9 µM 5.57E-6 SWF1 & branched chain AA biosynthesis 6 8.59E-7 0.64
15 SGTC_3286 9117135 4.73 37.2 µM 6.87E-6 5 1.10E-6 0.19
16 SGTC_879 0831-1030 4.68 162.0 µM 8.49E-6 12 1.41E-6 0.03
17 SGTC_1275 0867-0008 4.56 21.1 µM 1.39E-5 1 2.53E-6 0.30
18 SGTC_1425 4048-4433 4.21 7.3 µM 5.63E-5 copper-dependent oxidative stress 4 1.30E-5 0.06
19 SGTC_118 0083-0097 4.11 135.3 µM 8.09E-5 translation 16 1.99E-5 0.08
20 SGTC_3148 9097893 4.06 49.5 µM 9.75E-5 7 2.48E-5 0.21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.633 0 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.530 4.50E-242 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.516 1.70E-227 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.433 2.34E-153 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.397 9.31E-127 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.396 1.74E-126 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.388 2.72E-121 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.370 1.84E-109 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.353 4.05E-99 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.346 8.56E-95 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.345 2.52E-94 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.293 2.87E-67 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.256 4.17E-51 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.207 8.97E-34 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.202 3.93E-32 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein