HIPHOP chemogenomics database

YDL111C / RRP42

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDL111C / RRP42

Click on Significant Values for Screen Details

Top fitness defect scores for YDL111C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1698	5-fluorocytosine	14.70	1.1 µM	3.89E-42	exosome	1	1.81E-49	3.55
2	SGTC_1077	5-fluorocytosine	13.10	377.0 nM	9.84E-34	exosome	1	1.53E-39	1.07
3	SGTC_423	5-fluorouracil	10.10	457.0 µM	9.34E-21	exosome	7	3.24E-24	2.32
4	SGTC_242	5hr heat shock (37°C) + 5-fluorouracil	9.40	4.6 µM	2.91E-18	heat shock/prefoldin	6	2.85E-21	2.35
5	SGTC_1074	carmofur	9.29	3.8 µM	6.75E-18	exosome	6	7.67E-21	0.76
6	SGTC_610	4215-0184	8.80	155.0 µM	3.12E-16	exosome	5	7.08E-19	1.37
7	SGTC_617	3770-0098	7.57	35.0 µM	1.70E-12	exosome	11	1.81E-14	0.35
8	SGTC_3337	9144342	7.25	33.5 µM	1.37E-11		3	2.12E-13	1.40
9	SGTC_261	5-fluorouridine	6.85	15.4 µM	1.51E-10	exosome	3	3.59E-12	1.22
10	SGTC_976	1348-1067	5.90	47.6 µM	2.92E-8	60S ribosome export	3	1.78E-9	1.19
11	SGTC_2053	5265679	5.09	138.0 µM	1.45E-6		3	1.76E-7	0.79
12	SGTC_1887	st057648	5.07	70.8 µM	1.59E-6		1	1.96E-7	0.39
13	SGTC_3205	9113483	5.05	49.5 µM	1.75E-6		2	2.20E-7	0.40
14	SGTC_984	1492-0255	4.78	2.9 µM	5.57E-6	SWF1 & branched chain AA biosynthesis	6	8.59E-7	0.64
15	SGTC_3286	9117135	4.73	37.2 µM	6.87E-6		5	1.10E-6	0.19
16	SGTC_879	0831-1030	4.68	162.0 µM	8.49E-6		12	1.41E-6	0.03
17	SGTC_1275	0867-0008	4.56	21.1 µM	1.39E-5		1	2.53E-6	0.30
18	SGTC_1425	4048-4433	4.21	7.3 µM	5.63E-5	copper-dependent oxidative stress	4	1.30E-5	0.06
19	SGTC_118	0083-0097	4.11	135.3 µM	8.09E-5	translation	16	1.99E-5	0.08
20	SGTC_3148	9097893	4.06	49.5 µM	9.75E-5		7	2.48E-5	0.21

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.633	0	YGR195W	SKI6	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.530	4.50E-242	YOL021C	DIS3	het	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.516	1.70E-227	YGR158C	MTR3	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.433	2.34E-153	YDR280W	RRP45	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.397	9.31E-127	YPL044C_d	YPL044C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.396	1.74E-126	YPR142C_d	YPR142C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.388	2.72E-121	YPL043W	NOP4	het	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.370	1.84E-109	YKL172W	EBP2	het	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.353	4.05E-99	YGR095C	RRP46	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.346	8.56E-95	YPR143W	RRP15	het	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.345	2.52E-94	YNL232W	CSL4	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.293	2.87E-67	YNL002C	RLP7	het	Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.256	4.17E-51	YNL061W	NOP2	het	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.207	8.97E-34	YKL021C	MAK11	het	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.202	3.93E-32	YDR060W	MAK21	het	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein