YDL112W / TRM3

2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL112W / TRM3

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.12|P-value:3.13E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.42|P-value:4.50E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.34|P-value:6.04E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:6.68|P-value:3.74E-11 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.41|P-value:9.03E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.67|P-value:1.87E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.55|P-value:2.82E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.96|P-value:5.93E-5 ID:SGTC_500|Compound:h-89|FD-Score:4.40|P-value:9.59E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.50|P-value:2.60E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.70|P-value:1.67E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.61|P-value:2.31E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.82|P-value:1.34E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.94|P-value:6.48E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.34|P-value:1.24E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.25|P-value:8.18E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.43|P-value:8.14E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.59|P-value:2.49E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.34|P-value:5.93E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.57|P-value:2.04E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.37|P-value:5.42E-4 ID:SGTC_1675|Compound:st018485|FD-Score:5.88|P-value:5.04E-9 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.75|P-value:1.06E-8 ID:SGTC_1776|Compound:st049249|FD-Score:-3.23|P-value:6.84E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.62|P-value:3.47E-6 ID:SGTC_1805|Compound:st050013|FD-Score:-3.55|P-value:2.14E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.59|P-value:1.85E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.26|P-value:1.74E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.44|P-value:3.20E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.48|P-value:2.78E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-4.01|P-value:3.59E-5 ID:SGTC_1983|Compound:st071813|FD-Score:-3.92|P-value:5.30E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.10|P-value:3.43E-5 ID:SGTC_2062|Compound:5245942|FD-Score:3.85|P-value:9.31E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.24|P-value:6.48E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.44|P-value:4.22E-4 ID:SGTC_2078|Compound:5212016|FD-Score:7.92|P-value:5.27E-15 ID:SGTC_2079|Compound:5212404|FD-Score:3.97|P-value:5.68E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.48|P-value:3.64E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.95|P-value:3.36E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.17|P-value:1.83E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:6.33|P-value:3.48E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.67|P-value:1.87E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.62|P-value:1.64E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.51|P-value:3.30E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-9.24|P-value:4.78E-20 ID:SGTC_2986|Compound:9022445|FD-Score:-3.80|P-value:8.54E-5 ID:SGTC_3057|Compound:9095946|FD-Score:4.30|P-value:1.44E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.04|P-value:3.25E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.87|P-value:6.24E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.24|P-value:8.55E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.81|P-value:1.09E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.27|P-value:7.69E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.12|P-value:3.13E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.42|P-value:4.50E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.34|P-value:6.04E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:6.68|P-value:3.74E-11 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.41|P-value:9.03E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.67|P-value:1.87E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.55|P-value:2.82E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.96|P-value:5.93E-5 ID:SGTC_500|Compound:h-89|FD-Score:4.40|P-value:9.59E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.50|P-value:2.60E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.70|P-value:1.67E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.61|P-value:2.31E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.82|P-value:1.34E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.94|P-value:6.48E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.34|P-value:1.24E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.25|P-value:8.18E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.43|P-value:8.14E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.59|P-value:2.49E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.34|P-value:5.93E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.57|P-value:2.04E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.37|P-value:5.42E-4 ID:SGTC_1675|Compound:st018485|FD-Score:5.88|P-value:5.04E-9 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.75|P-value:1.06E-8 ID:SGTC_1776|Compound:st049249|FD-Score:-3.23|P-value:6.84E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.62|P-value:3.47E-6 ID:SGTC_1805|Compound:st050013|FD-Score:-3.55|P-value:2.14E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.59|P-value:1.85E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.26|P-value:1.74E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.44|P-value:3.20E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.48|P-value:2.78E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-4.01|P-value:3.59E-5 ID:SGTC_1983|Compound:st071813|FD-Score:-3.92|P-value:5.30E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.10|P-value:3.43E-5 ID:SGTC_2062|Compound:5245942|FD-Score:3.85|P-value:9.31E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.24|P-value:6.48E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.44|P-value:4.22E-4 ID:SGTC_2078|Compound:5212016|FD-Score:7.92|P-value:5.27E-15 ID:SGTC_2079|Compound:5212404|FD-Score:3.97|P-value:5.68E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.48|P-value:3.64E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.95|P-value:3.36E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.17|P-value:1.83E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:6.33|P-value:3.48E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.67|P-value:1.87E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.62|P-value:1.64E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.51|P-value:3.30E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-9.24|P-value:4.78E-20 ID:SGTC_2986|Compound:9022445|FD-Score:-3.80|P-value:8.54E-5 ID:SGTC_3057|Compound:9095946|FD-Score:4.30|P-value:1.44E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.04|P-value:3.25E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.87|P-value:6.24E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.24|P-value:8.55E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.81|P-value:1.09E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.27|P-value:7.69E-4

Top fitness defect scores for YDL112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2078 5212016 7.92 200.0 µM 5.27E-15 60S ribosome export 1 1.16E-15
2 SGTC_361 000s-0510 6.68 1.4 µM 3.74E-11 3 1.22E-11
3 SGTC_2586 curcumin 6.33 80.0 µM 3.48E-10 iron homeostasis 11 1.25E-10
4 SGTC_2575 plumbagin 5.95 510.0 nM 3.36E-9 superoxide 15 1.34E-9
5 SGTC_1675 st018485 5.88 24.5 µM 5.04E-9 60S ribosome export 7 2.04E-9
6 SGTC_1681 tripelennamine 5.75 100.0 µM 1.06E-8 5 4.44E-9
7 SGTC_660 4031-1742 4.82 102.0 µM 1.34E-6 redox potentiating 24 7.02E-7
8 SGTC_1777 st045864 4.62 34.8 µM 3.47E-6 4 1.90E-6
9 SGTC_1030 k029-0042 4.43 36.7 µM 8.14E-6 TSC3-RPN4 14 4.63E-6
10 SGTC_449 xestospongin c 4.41 11.2 µM 9.03E-6 NEO1-PIK1 47 5.16E-6
11 SGTC_500 h-89 4.40 112.0 µM 9.59E-6 cell wall signaling 22 5.50E-6
12 SGTC_943 3253-1379 4.34 105.0 µM 1.24E-5 21 7.18E-6
13 SGTC_3057 9095946 4.30 49.5 µM 1.44E-5 Golgi 8 8.40E-6
14 SGTC_1912 st060209 4.26 90.8 µM 1.74E-5 31 1.03E-5
15 SGTC_143 4032-1194 4.12 15.7 µM 3.13E-5 58 1.90E-5
16 SGTC_2044 5102272 4.10 200.0 µM 3.43E-5 7 2.09E-5
17 SGTC_2079 5212404 3.97 121.0 µM 5.68E-5 14 3.54E-5
18 SGTC_485 niflumic acid 3.96 177.0 µM 5.93E-5 11 3.70E-5
19 SGTC_748 0136-0228 3.94 77.9 µM 6.48E-5 redox potentiating 79 4.06E-5
20 SGTC_2062 5245942 3.85 200.0 µM 9.31E-5 23 5.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.48E-13 YER085C_p YER085C_p hom Putative protein of unknown function
0.118 7.96E-12 YDR263C DIN7 hom Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
0.108 2.98E-10 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.108 3.78E-10 YLR437C DIF1 hom Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein
0.108 4.06E-10 YGL120C PRP43 het RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
0.100 5.99E-9 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.098 1.49E-8 YEL055C POL5 het DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
0.096 2.20E-8 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.087 3.94E-7 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.083 1.42E-6 YIL047C SYG1 hom Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
0.083 1.70E-6 YDR307W_p PMT7_p hom Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation
0.076 9.96E-6 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 1.67E-5 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.074 1.87E-5 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.073 2.25E-5 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants