YDL119C_p

Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL119C / YDL119C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.50|P-value:4.64E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.40|P-value:6.47E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.24|P-value:3.10E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.46|P-value:5.92E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:6.61|P-value:2.20E-10 ID:SGTC_86|Compound:0417-1630|FD-Score:5.68|P-value:4.14E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:8.32|P-value:2.06E-15 ID:SGTC_142|Compound:0335-0849|FD-Score:7.10|P-value:1.03E-11 ID:SGTC_171|Compound:k064-0041|FD-Score:10.10|P-value:1.26E-21 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.99|P-value:9.19E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.62|P-value:6.46E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:14.40|P-value:1.64E-42 ID:SGTC_252|Compound:miconazole|FD-Score:5.99|P-value:7.88E-9 ID:SGTC_254|Compound:nsc-64875|FD-Score:7.05|P-value:1.45E-11 ID:SGTC_258|Compound:haloperidol|FD-Score:5.72|P-value:3.30E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:5.82|P-value:1.96E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:5.58|P-value:6.73E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.05|P-value:6.77E-9 ID:SGTC_350|Compound:k064-0020|FD-Score:7.65|P-value:2.61E-13 ID:SGTC_383|Compound:2324-0395|FD-Score:5.08|P-value:7.98E-7 ID:SGTC_398|Compound:bronopol|FD-Score:-3.45|P-value:6.13E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:5.16E-4 ID:SGTC_490|Compound:phenamil|FD-Score:6.30|P-value:1.36E-9 ID:SGTC_492|Compound:tmb-8|FD-Score:3.56|P-value:3.76E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.32|P-value:2.59E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.63|P-value:6.23E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:6.79|P-value:7.50E-11 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.77|P-value:2.06E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:5.55|P-value:8.14E-8 ID:SGTC_584|Compound:0986-0246|FD-Score:6.49|P-value:4.41E-10 ID:SGTC_607|Compound:4491-0986|FD-Score:7.43|P-value:1.19E-12 ID:SGTC_625|Compound:k213-0058|FD-Score:3.95|P-value:9.52E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.13|P-value:4.81E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:7.98|P-value:2.52E-14 ID:SGTC_754|Compound:3474-0146|FD-Score:5.79|P-value:2.34E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:6.67|P-value:1.59E-10 ID:SGTC_864|Compound:0469-0573|FD-Score:4.07|P-value:6.09E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:5.06|P-value:8.74E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.47|P-value:1.20E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:7.01|P-value:1.88E-11 ID:SGTC_978|Compound:1416-0512|FD-Score:3.92|P-value:1.05E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.54|P-value:4.07E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.94|P-value:2.90E-11 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.48|P-value:5.07E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.96|P-value:2.55E-11 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.34|P-value:2.08E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.57|P-value:3.73E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.62|P-value:3.08E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.42|P-value:1.52E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:10.60|P-value:7.06E-24 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.78|P-value:1.76E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:9.53|P-value:1.28E-19 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.37|P-value:7.08E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.67|P-value:1.56E-10 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.16|P-value:4.29E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.33|P-value:9.04E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.52|P-value:9.60E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.04|P-value:9.74E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.04|P-value:6.60E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.40|P-value:6.48E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.38|P-value:1.74E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.28|P-value:9.50E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.22|P-value:3.38E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.59|P-value:2.53E-10 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.70|P-value:2.00E-24 ID:SGTC_1660|Compound:st012960|FD-Score:4.04|P-value:6.83E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.12|P-value:4.05E-18 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.50|P-value:5.01E-10 ID:SGTC_1752|Compound:st044819|FD-Score:3.61|P-value:3.21E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.53|P-value:4.33E-16 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.10|P-value:7.28E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.17|P-value:4.05E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.36|P-value:7.39E-4 ID:SGTC_2021|Compound:4019055|FD-Score:8.27|P-value:2.97E-15 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:3.77E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.62|P-value:3.44E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.91|P-value:1.11E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.39|P-value:7.49E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.65|P-value:2.76E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.86|P-value:1.45E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.40|P-value:7.14E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.79|P-value:1.70E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.37|P-value:7.85E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.58|P-value:3.51E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.77|P-value:2.05E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.24|P-value:3.47E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.53|P-value:9.39E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:9.48|P-value:2.00E-19 ID:SGTC_2647|Compound:atorvastatin|FD-Score:8.40|P-value:1.19E-15 ID:SGTC_2648|Compound:atorvastatin|FD-Score:10.90|P-value:6.97E-25 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.88|P-value:1.23E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.75|P-value:3.66E-6 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:5.93|P-value:1.08E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.28|P-value:9.74E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.69|P-value:4.71E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.81|P-value:1.79E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.35|P-value:8.39E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.51|P-value:5.05E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.72|P-value:2.17E-4 ID:SGTC_2872|Compound:9044037|FD-Score:-3.79|P-value:1.88E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.97|P-value:8.65E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.40|P-value:1.61E-5 ID:SGTC_3347|Compound:9188721|FD-Score:5.31|P-value:2.64E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:3.50|P-value:4.64E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.40|P-value:6.47E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.24|P-value:3.10E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.46|P-value:5.92E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:6.61|P-value:2.20E-10 ID:SGTC_86|Compound:0417-1630|FD-Score:5.68|P-value:4.14E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:8.32|P-value:2.06E-15 ID:SGTC_142|Compound:0335-0849|FD-Score:7.10|P-value:1.03E-11 ID:SGTC_171|Compound:k064-0041|FD-Score:10.10|P-value:1.26E-21 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.99|P-value:9.19E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.62|P-value:6.46E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:14.40|P-value:1.64E-42 ID:SGTC_252|Compound:miconazole|FD-Score:5.99|P-value:7.88E-9 ID:SGTC_254|Compound:nsc-64875|FD-Score:7.05|P-value:1.45E-11 ID:SGTC_258|Compound:haloperidol|FD-Score:5.72|P-value:3.30E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:5.82|P-value:1.96E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:5.58|P-value:6.73E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.05|P-value:6.77E-9 ID:SGTC_350|Compound:k064-0020|FD-Score:7.65|P-value:2.61E-13 ID:SGTC_383|Compound:2324-0395|FD-Score:5.08|P-value:7.98E-7 ID:SGTC_398|Compound:bronopol|FD-Score:-3.45|P-value:6.13E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:5.16E-4 ID:SGTC_490|Compound:phenamil|FD-Score:6.30|P-value:1.36E-9 ID:SGTC_492|Compound:tmb-8|FD-Score:3.56|P-value:3.76E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.32|P-value:2.59E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.63|P-value:6.23E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:6.79|P-value:7.50E-11 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.77|P-value:2.06E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:5.55|P-value:8.14E-8 ID:SGTC_584|Compound:0986-0246|FD-Score:6.49|P-value:4.41E-10 ID:SGTC_607|Compound:4491-0986|FD-Score:7.43|P-value:1.19E-12 ID:SGTC_625|Compound:k213-0058|FD-Score:3.95|P-value:9.52E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.13|P-value:4.81E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:7.98|P-value:2.52E-14 ID:SGTC_754|Compound:3474-0146|FD-Score:5.79|P-value:2.34E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:6.67|P-value:1.59E-10 ID:SGTC_864|Compound:0469-0573|FD-Score:4.07|P-value:6.09E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:5.06|P-value:8.74E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.47|P-value:1.20E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:7.01|P-value:1.88E-11 ID:SGTC_978|Compound:1416-0512|FD-Score:3.92|P-value:1.05E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.54|P-value:4.07E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.94|P-value:2.90E-11 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.48|P-value:5.07E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.96|P-value:2.55E-11 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.34|P-value:2.08E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.57|P-value:3.73E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.62|P-value:3.08E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.42|P-value:1.52E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:10.60|P-value:7.06E-24 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.78|P-value:1.76E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:9.53|P-value:1.28E-19 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.37|P-value:7.08E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.67|P-value:1.56E-10 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.16|P-value:4.29E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.33|P-value:9.04E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.52|P-value:9.60E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.04|P-value:9.74E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.04|P-value:6.60E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.40|P-value:6.48E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.38|P-value:1.74E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.28|P-value:9.50E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.22|P-value:3.38E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.59|P-value:2.53E-10 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.70|P-value:2.00E-24 ID:SGTC_1660|Compound:st012960|FD-Score:4.04|P-value:6.83E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.12|P-value:4.05E-18 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.50|P-value:5.01E-10 ID:SGTC_1752|Compound:st044819|FD-Score:3.61|P-value:3.21E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.53|P-value:4.33E-16 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.10|P-value:7.28E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.17|P-value:4.05E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.36|P-value:7.39E-4 ID:SGTC_2021|Compound:4019055|FD-Score:8.27|P-value:2.97E-15 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:3.77E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.62|P-value:3.44E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.91|P-value:1.11E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.39|P-value:7.49E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.65|P-value:2.76E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.86|P-value:1.45E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.40|P-value:7.14E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.79|P-value:1.70E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.37|P-value:7.85E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.58|P-value:3.51E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.77|P-value:2.05E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.24|P-value:3.47E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.53|P-value:9.39E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:9.48|P-value:2.00E-19 ID:SGTC_2647|Compound:atorvastatin|FD-Score:8.40|P-value:1.19E-15 ID:SGTC_2648|Compound:atorvastatin|FD-Score:10.90|P-value:6.97E-25 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.88|P-value:1.23E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.75|P-value:3.66E-6 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:5.93|P-value:1.08E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.28|P-value:9.74E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.69|P-value:4.71E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.81|P-value:1.79E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.35|P-value:8.39E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.51|P-value:5.05E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.72|P-value:2.17E-4 ID:SGTC_2872|Compound:9044037|FD-Score:-3.79|P-value:1.88E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.97|P-value:8.65E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.40|P-value:1.61E-5 ID:SGTC_3347|Compound:9188721|FD-Score:5.31|P-value:2.64E-7

Top fitness defect scores for YDL119C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_227 fluconazole 14.40 33.5 µM 1.64E-42 azole & statin 6 1.35E-47
2 SGTC_2648 atorvastatin 10.90 78.7 µM 6.97E-25 azole & statin 3 9.49E-28
3 SGTC_1495 4469-0029 10.70 237.0 µM 2.00E-24 13 3.11E-27
4 SGTC_1226 3909-7979 10.60 35.4 µM 7.06E-24 4 1.28E-26
5 SGTC_171 k064-0041 10.10 9.7 µM 1.26E-21 heme requiring 3 4.38E-24
6 SGTC_1290 0986-0249 9.53 10.2 µM 1.28E-19 DNA intercalators 1 7.97E-22
7 SGTC_2619 obliquin 9.48 87.9 µM 2.00E-19 cell wall 26 1.31E-21
8 SGTC_1712 st032288 9.12 53.4 µM 4.05E-18 calcium & mitochondrial duress 31 3.87E-20
9 SGTC_1788 fluconazole 8.53 20.0 µM 4.33E-16 azole & statin 16 7.39E-18
10 SGTC_2647 atorvastatin 8.40 60.2 µM 1.19E-15 azole & statin 5 2.30E-17
11 SGTC_137 0438-0332 8.32 85.4 µM 2.06E-15 ubiquinone biosynthesis & proteasome 33 4.28E-17
12 SGTC_2021 4019055 8.27 173.0 µM 2.97E-15 endomembrane recycling 21 6.43E-17
13 SGTC_690 glyoxal 7.98 20.3 µM 2.52E-14 29 7.13E-16
14 SGTC_350 k064-0020 7.65 19.8 µM 2.61E-13 heme requiring 5 9.84E-15
15 SGTC_607 4491-0986 7.43 66.8 µM 1.19E-12 heme requiring 3 5.39E-14
16 SGTC_142 0335-0849 7.10 62.7 µM 1.03E-11 ubiquinone biosynthesis & proteasome 51 6.09E-13
17 SGTC_254 nsc-64875 7.05 3.8 µM 1.45E-11 ergosterol depletion effects on membrane 11 8.96E-13
18 SGTC_916 4466-0038 7.01 42.0 nM 1.88E-11 cell wall 19 1.20E-12
19 SGTC_1097 itavastatin 6.96 7.2 µM 2.55E-11 azole & statin 4 1.69E-12
20 SGTC_1067 clotrimazole 6.94 1.4 µM 2.90E-11 azole & statin 6 1.96E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.599 0 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.357 2.23E-101 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.291 1.07E-66 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.272 4.55E-58 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.261 1.67E-53 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.240 2.47E-45 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.230 2.10E-41 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.222 7.34E-39 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.221 1.53E-38 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.206 1.23E-33 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.203 1.83E-32 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.199 2.38E-31 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.196 1.57E-30 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.195 3.76E-30 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.184 5.30E-27 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6