YDL120W / YFH1

Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL120W / YFH1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:3.17|P-value:1.98E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-2.83|P-value:9.07E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.06|P-value:3.63E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.29|P-value:1.60E-12 ID:SGTC_167|Compound:3672-0051|FD-Score:3.11|P-value:2.55E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.41|P-value:6.86E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.30|P-value:1.14E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.64|P-value:2.85E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.25|P-value:1.38E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:2.81|P-value:8.36E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:2.91|P-value:5.72E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.80|P-value:8.60E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.33|P-value:9.86E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.61|P-value:2.76E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.39|P-value:7.51E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.35|P-value:9.27E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.32|P-value:1.02E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.63|P-value:2.48E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.95|P-value:4.77E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.60|P-value:2.95E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.11|P-value:2.53E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-2.82|P-value:9.29E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.31|P-value:7.37E-7 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.27|P-value:9.64E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.55|P-value:3.62E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:2.78|P-value:9.46E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.61|P-value:2.80E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.17|P-value:2.36E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:2.85|P-value:7.07E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.24|P-value:1.75E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.08|P-value:2.58E-6 ID:SGTC_1757|Compound:st041620|FD-Score:-3.09|P-value:3.23E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-2.82|P-value:9.24E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.61|P-value:3.23E-5 ID:SGTC_1907|Compound:st060210|FD-Score:4.78|P-value:4.88E-8 ID:SGTC_1923|Compound:st058458|FD-Score:4.96|P-value:1.62E-8 ID:SGTC_2017|Compound:5132927|FD-Score:3.08|P-value:2.82E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.67|P-value:2.52E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-4.15|P-value:2.20E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-4.33|P-value:8.19E-7 ID:SGTC_2059|Compound:5238311|FD-Score:-3.71|P-value:2.09E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-2.82|P-value:9.17E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.22|P-value:1.59E-4 ID:SGTC_2263|Compound:7948595|FD-Score:2.95|P-value:4.82E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.95|P-value:1.62E-11 ID:SGTC_2382|Compound:9035899|FD-Score:3.49|P-value:4.77E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.15|P-value:2.16E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.35|P-value:8.89E-5 ID:SGTC_2700|Compound:st077718|FD-Score:2.98|P-value:4.29E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.39|P-value:9.16E-5 ID:SGTC_2819|Compound:7996655|FD-Score:2.95|P-value:4.89E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.11|P-value:2.95E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.84|P-value:7.48E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.85|P-value:7.18E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.17|P-value:1.98E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-2.83|P-value:9.07E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.06|P-value:3.63E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.29|P-value:1.60E-12 ID:SGTC_167|Compound:3672-0051|FD-Score:3.11|P-value:2.55E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.41|P-value:6.86E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.30|P-value:1.14E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.64|P-value:2.85E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.25|P-value:1.38E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:2.81|P-value:8.36E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:2.91|P-value:5.72E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.80|P-value:8.60E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.33|P-value:9.86E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.61|P-value:2.76E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.39|P-value:7.51E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.35|P-value:9.27E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.32|P-value:1.02E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.63|P-value:2.48E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.95|P-value:4.77E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.60|P-value:2.95E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.11|P-value:2.53E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-2.82|P-value:9.29E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.31|P-value:7.37E-7 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.27|P-value:9.64E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.55|P-value:3.62E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:2.78|P-value:9.46E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.61|P-value:2.80E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.17|P-value:2.36E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:2.85|P-value:7.07E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.24|P-value:1.75E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.08|P-value:2.58E-6 ID:SGTC_1757|Compound:st041620|FD-Score:-3.09|P-value:3.23E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-2.82|P-value:9.24E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.61|P-value:3.23E-5 ID:SGTC_1907|Compound:st060210|FD-Score:4.78|P-value:4.88E-8 ID:SGTC_1923|Compound:st058458|FD-Score:4.96|P-value:1.62E-8 ID:SGTC_2017|Compound:5132927|FD-Score:3.08|P-value:2.82E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.67|P-value:2.52E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-4.15|P-value:2.20E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-4.33|P-value:8.19E-7 ID:SGTC_2059|Compound:5238311|FD-Score:-3.71|P-value:2.09E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-2.82|P-value:9.17E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.22|P-value:1.59E-4 ID:SGTC_2263|Compound:7948595|FD-Score:2.95|P-value:4.82E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.95|P-value:1.62E-11 ID:SGTC_2382|Compound:9035899|FD-Score:3.49|P-value:4.77E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.15|P-value:2.16E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.35|P-value:8.89E-5 ID:SGTC_2700|Compound:st077718|FD-Score:2.98|P-value:4.29E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.39|P-value:9.16E-5 ID:SGTC_2819|Compound:7996655|FD-Score:2.95|P-value:4.89E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.11|P-value:2.95E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.84|P-value:7.48E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.85|P-value:7.18E-4

Top fitness defect scores for YDL120W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2365 9042475 5.95 200.0 µM 1.62E-11 1 1.32E-9 0.72
2 SGTC_1923 st058458 4.96 19.1 µM 1.62E-8 6 3.59E-7 0.19
3 SGTC_1907 st060210 4.78 83.7 µM 4.88E-8 5 8.82E-7 0.33
4 SGTC_1302 1159-0335 4.31 255.0 µM 7.37E-7 2 8.01E-6 0.00
5 SGTC_1317 1273-0028 4.27 910.0 nM 9.64E-7 azole & statin 10 9.96E-6 0.15
6 SGTC_1737 st035557 4.08 69.7 µM 2.58E-6 6 2.22E-5 0.23
7 SGTC_976 1348-1067 3.63 47.6 µM 2.48E-5 60S ribosome export 11 1.40E-4 0.12
8 SGTC_923 1900-2434 3.61 73.3 µM 2.76E-5 RNA processing & uracil transport 16 1.53E-4 0.03
9 SGTC_1497 4476-2978 3.61 41.3 µM 2.80E-5 7 1.55E-4 0.01
10 SGTC_1238 0333-0287 3.60 48.8 µM 2.95E-5 Golgi 6 1.61E-4 0.17
11 SGTC_1450 4112-4260 3.55 37.6 µM 3.62E-5 calcium & mitochondrial duress 7 1.91E-4 0.01
12 SGTC_2382 9035899 3.49 200.0 µM 4.77E-5 60S ribosome export 8 2.39E-4 0.16
13 SGTC_184 1494-0393 3.41 24.7 µM 6.86E-5 42 3.21E-4 0.05
14 SGTC_958 1222-0007 3.39 33.0 µM 7.51E-5 11 3.46E-4 0.04
15 SGTC_2591 skatole 3.35 100.0 µM 8.89E-5 10 3.97E-4 0.02
16 SGTC_968 1309-0633 3.35 340.0 µM 9.27E-5 8 4.11E-4 0.08
17 SGTC_912 3474-0017 3.33 2.2 µM 9.86E-5 10 4.32E-4 0.14
18 SGTC_969 1313-0238 3.32 134.0 µM 1.02E-4 mitochondrial processes 31 4.45E-4 0.03
19 SGTC_218 alverine citrate 3.30 93.8 µM 1.14E-4 fatty acid desaturase (OLE1) 13 4.88E-4 0.10
20 SGTC_234 nsc-17383 3.25 10.7 µM 1.38E-4 ERG2 12 5.68E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.85E-16 YDR292C SRP101 het Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
0.138 8.35E-16 YOL034W SMC5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
0.130 3.80E-14 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.125 3.48E-13 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.124 5.20E-13 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.124 5.98E-13 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.123 9.11E-13 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.117 1.30E-11 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.116 1.74E-11 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.110 1.92E-10 YJR076C CDC11 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.104 1.60E-9 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.102 3.54E-9 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.099 7.85E-9 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.099 8.97E-9 YGR271W SLH1 hom Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
0.099 1.07E-8 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.