HIPHOP chemogenomics database

YDL122W / UBP1

Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL122W / UBP1

Click on Significant Values for Screen Details

Top fitness defect scores for YDL122W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_103	0844-0104	13.60	51.8 µM	1.83E-43	ERAD & cell cycle	12	3.83E-42
2	SGTC_188	3229-0966	7.95	278.5 µM	3.02E-16		6	9.27E-16
3	SGTC_1772	st048439	7.15	82.2 µM	1.67E-13		6	4.21E-13
4	SGTC_114	0364-0001	6.48	490.3 µM	2.08E-11		7	4.51E-11
5	SGTC_1161	k007-0610	4.97	110.0 µM	2.04E-7	ERAD & cell cycle	83	3.33E-7
6	SGTC_971	1315-0384	4.95	26.7 µM	2.31E-7	cell wall signaling	10	3.75E-7
7	SGTC_1658	st012944	4.89	20.0 µM	3.20E-7	iron homeostasis	48	5.13E-7
8	SGTC_568	1193-0097	4.82	7.5 µM	4.59E-7	ERAD & cell cycle	94	7.29E-7
9	SGTC_43	0570-0105	4.75	72.5 µM	6.34E-7	ERG2	57	9.95E-7
10	SGTC_983	1491-0821	4.54	12.2 µM	1.90E-6		6	2.88E-6
11	SGTC_143	4032-1194	4.41	15.7 µM	3.51E-6		45	5.22E-6
12	SGTC_2076	5212012	3.99	200.0 µM	2.40E-5		5	3.36E-5
13	SGTC_1464	k208-0027	3.88	110.0 µM	3.74E-5		27	5.16E-5
14	SGTC_1234	0326-0494	3.79	15.5 µM	5.44E-5		18	7.42E-5
15	SGTC_2991	9074669	3.77	71.4 µM	6.06E-5	azole & statin	73	8.23E-5
16	SGTC_2328	6201408	3.76	200.0 µM	6.15E-5		23	8.35E-5
17	SGTC_25	0118-0223	3.64	35.7 µM	1.03E-4		21	1.37E-4
18	SGTC_3219	9131112	3.56	49.5 µM	1.40E-4	Golgi	46	1.85E-4
19	SGTC_3286	9117135	3.56	37.2 µM	1.42E-4		26	1.88E-4
20	SGTC_2810	7959871	3.54	45.5 µM	1.51E-4	copper-dependent oxidative stress	53	1.99E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.321	7.03E-81	YDL148C	NOP14	het	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.297	4.16E-69	YOL065C	INP54	hom	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.272	9.27E-58	YER084W_p	YER084W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.247	1.48E-47	YMR029C	FAR8	hom	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.244	1.05E-46	YDR199W_d	YDR199W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.240	5.76E-45	YDR186C	YDR186C	hom	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.213	1.13E-35	YOR363C	PIP2	hom	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.210	7.99E-35	YIL030C	SSM4	hom	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.209	2.24E-34	YOL002C	IZH2	hom	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.206	1.70E-33	YDL126C	CDC48	het	AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.205	5.93E-33	YMR052C-A_d	YMR052C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204	1.27E-32	YDL100C	GET3	hom	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.203	1.58E-32	YDL190C	UFD2	hom	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.197	1.24E-30	YLR407W_p	YLR407W_p	hom	Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.194	1.21E-29	YMR052W	FAR3	hom	Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress