YDL124W

NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL124W / YDL124W

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:-2.85|P-value:6.55E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.03|P-value:6.56E-9 ID:SGTC_251|Compound:melphalan|FD-Score:3.24|P-value:1.24E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:2.94|P-value:4.51E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.07|P-value:2.59E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-2.99|P-value:3.76E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.42|P-value:5.85E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.86|P-value:2.02E-8 ID:SGTC_398|Compound:bronopol|FD-Score:3.18|P-value:1.62E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.82|P-value:7.94E-6 ID:SGTC_898|Compound:1000-0849|FD-Score:2.93|P-value:4.56E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.89|P-value:5.43E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:2.80|P-value:7.68E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.08|P-value:2.51E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.74|P-value:1.25E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:2.84|P-value:6.63E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.13|P-value:1.98E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.66|P-value:1.78E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.14|P-value:1.98E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.85|P-value:6.59E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:2.96|P-value:4.09E-4 ID:SGTC_1558|Compound:st069300|FD-Score:2.90|P-value:5.25E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.28|P-value:1.05E-4 ID:SGTC_1700|Compound:st030840|FD-Score:4.70|P-value:5.37E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.62|P-value:1.18E-10 ID:SGTC_1811|Compound:st050069|FD-Score:3.34|P-value:7.84E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-5.54|P-value:2.06E-10 ID:SGTC_1841|Compound:st054148|FD-Score:-3.05|P-value:2.97E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.33|P-value:8.55E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.51|P-value:3.67E-5 ID:SGTC_1855|Compound:st056195|FD-Score:5.13|P-value:3.29E-9 ID:SGTC_1861|Compound:st057647|FD-Score:4.11|P-value:1.69E-6 ID:SGTC_1917|Compound:st066507|FD-Score:2.98|P-value:3.76E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-2.77|P-value:8.95E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.46|P-value:4.68E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.03|P-value:3.10E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-2.98|P-value:3.85E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.45|P-value:4.78E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.20|P-value:1.50E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.06|P-value:2.82E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.72|P-value:1.31E-5 ID:SGTC_2780|Compound:5215298|FD-Score:2.96|P-value:4.06E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.92|P-value:4.86E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.02|P-value:3.17E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.35|P-value:7.51E-5 ID:SGTC_2829|Compound:7992743|FD-Score:4.51|P-value:1.72E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.76|P-value:1.12E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.71|P-value:1.38E-5 ID:SGTC_2929|Compound:9013348|FD-Score:2.87|P-value:5.96E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.94|P-value:4.49E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.28|P-value:1.03E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.18|P-value:1.15E-6 ID:SGTC_3225|Compound:9130819|FD-Score:3.03|P-value:3.11E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:-2.85|P-value:6.55E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.03|P-value:6.56E-9 ID:SGTC_251|Compound:melphalan|FD-Score:3.24|P-value:1.24E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:2.94|P-value:4.51E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.07|P-value:2.59E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-2.99|P-value:3.76E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.42|P-value:5.85E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.86|P-value:2.02E-8 ID:SGTC_398|Compound:bronopol|FD-Score:3.18|P-value:1.62E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.82|P-value:7.94E-6 ID:SGTC_898|Compound:1000-0849|FD-Score:2.93|P-value:4.56E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.89|P-value:5.43E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:2.80|P-value:7.68E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.08|P-value:2.51E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.74|P-value:1.25E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:2.84|P-value:6.63E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.13|P-value:1.98E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.66|P-value:1.78E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.14|P-value:1.98E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.85|P-value:6.59E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:2.96|P-value:4.09E-4 ID:SGTC_1558|Compound:st069300|FD-Score:2.90|P-value:5.25E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.28|P-value:1.05E-4 ID:SGTC_1700|Compound:st030840|FD-Score:4.70|P-value:5.37E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.62|P-value:1.18E-10 ID:SGTC_1811|Compound:st050069|FD-Score:3.34|P-value:7.84E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-5.54|P-value:2.06E-10 ID:SGTC_1841|Compound:st054148|FD-Score:-3.05|P-value:2.97E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.33|P-value:8.55E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.51|P-value:3.67E-5 ID:SGTC_1855|Compound:st056195|FD-Score:5.13|P-value:3.29E-9 ID:SGTC_1861|Compound:st057647|FD-Score:4.11|P-value:1.69E-6 ID:SGTC_1917|Compound:st066507|FD-Score:2.98|P-value:3.76E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-2.77|P-value:8.95E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.46|P-value:4.68E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.03|P-value:3.10E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-2.98|P-value:3.85E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.45|P-value:4.78E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.20|P-value:1.50E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.06|P-value:2.82E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.72|P-value:1.31E-5 ID:SGTC_2780|Compound:5215298|FD-Score:2.96|P-value:4.06E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.92|P-value:4.86E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.02|P-value:3.17E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.35|P-value:7.51E-5 ID:SGTC_2829|Compound:7992743|FD-Score:4.51|P-value:1.72E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.76|P-value:1.12E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.71|P-value:1.38E-5 ID:SGTC_2929|Compound:9013348|FD-Score:2.87|P-value:5.96E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.94|P-value:4.49E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.28|P-value:1.03E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.18|P-value:1.15E-6 ID:SGTC_3225|Compound:9130819|FD-Score:3.03|P-value:3.11E-4

Top fitness defect scores for YDL124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1855 st056195 5.13 39.6 µM 3.29E-9 60S ribosome export 3 1.42E-7
2 SGTC_65 0798-0905 5.03 35.0 µM 6.56E-9 calcium & mitochondrial duress 53 2.45E-7
3 SGTC_391 gliotoxin 4.86 8.3 µM 2.02E-8 42 5.96E-7
4 SGTC_1700 st030840 4.70 7.9 µM 5.37E-8 PDR1 12 1.29E-6
5 SGTC_2829 7992743 4.51 58.4 µM 1.72E-7 25 3.24E-6
6 SGTC_3128 9127691 4.18 49.5 µM 1.15E-6 19 1.45E-5
7 SGTC_1861 st057647 4.11 17.4 µM 1.69E-6 18 1.97E-5
8 SGTC_1487 3970-0795 3.85 2.8 µM 6.59E-6 DNA intercalators 13 5.79E-5
9 SGTC_869 0564-0080 3.82 44.1 µM 7.94E-6 26 6.72E-5
10 SGTC_2697 mebhydrolin 3.72 72.4 µM 1.31E-5 NEO1 73 9.98E-5
11 SGTC_2925 9010536 3.71 32.5 µM 1.38E-5 azole & statin 59 1.04E-4
12 SGTC_1468 k284-1086 3.66 134.0 µM 1.78E-5 DNA intercalators 52 1.27E-4
13 SGTC_1845 st056753 3.51 3.0 µM 3.67E-5 TSC3-RPN4 54 2.26E-4
14 SGTC_2108 5365811 3.46 200.0 µM 4.68E-5 34 2.75E-4
15 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.45 70.0 µM 4.78E-5 redox potentiating 95 2.79E-4
16 SGTC_2812 7970281 3.35 58.4 µM 7.51E-5 59 4.00E-4
17 SGTC_1811 st050069 3.34 61.5 µM 7.84E-5 15 4.14E-4
18 SGTC_3125 9127534 3.28 49.5 µM 1.03E-4 25 5.13E-4
19 SGTC_1675 st018485 3.28 24.5 µM 1.05E-4 60S ribosome export 60 5.24E-4
20 SGTC_251 melphalan 3.24 456.5 µM 1.24E-4 DNA damage response 56 5.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 9.51E-12 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.117 9.65E-12 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.114 3.57E-11 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.112 8.96E-11 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.110 1.94E-10 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.109 2.22E-10 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.105 1.20E-9 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.100 5.63E-9 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.099 1.04E-8 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.093 6.86E-8 YCR004C YCP4 hom Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.80E-7 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.090 2.03E-7 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.088 3.36E-7 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.087 4.77E-7 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.085 8.40E-7 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock