YDL130W-A / STF1

Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL130W-A / STF1

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:3.27|P-value:9.86E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.69|P-value:3.78E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.39|P-value:6.60E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.17|P-value:3.90E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.69|P-value:2.35E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.32|P-value:7.52E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:4.23|P-value:3.05E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.07|P-value:5.74E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.11|P-value:4.79E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.64|P-value:5.29E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.38|P-value:6.72E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.95|P-value:8.99E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:4.21|P-value:3.27E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.36|P-value:1.80E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.42|P-value:5.33E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.30|P-value:8.92E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.28|P-value:8.37E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.40|P-value:6.34E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.61|P-value:3.09E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.22|P-value:3.11E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.47|P-value:5.13E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.39|P-value:6.68E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.43|P-value:5.76E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-3.35|P-value:6.67E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.68|P-value:2.44E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:5.01|P-value:1.02E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.39|P-value:5.86E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.08|P-value:7.23E-7 ID:SGTC_2382|Compound:9035899|FD-Score:3.36|P-value:7.19E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.82|P-value:1.48E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.92|P-value:8.95E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.07|P-value:5.65E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.33|P-value:8.12E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.44|P-value:5.64E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.52|P-value:4.21E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.64|P-value:2.82E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.56|P-value:3.34E-4 ID:SGTC_2957|Compound:9076800|FD-Score:6.44|P-value:4.74E-10 ID:SGTC_2967|Compound:9089538|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.30|P-value:8.74E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.41|P-value:1.46E-5 ID:SGTC_3136|Compound:9095672|FD-Score:-3.49|P-value:4.23E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.71|P-value:2.22E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.27|P-value:9.86E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.69|P-value:3.78E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.39|P-value:6.60E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.17|P-value:3.90E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.69|P-value:2.35E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.32|P-value:7.52E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:4.23|P-value:3.05E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.07|P-value:5.74E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.11|P-value:4.79E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.64|P-value:5.29E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.38|P-value:6.72E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.95|P-value:8.99E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:4.21|P-value:3.27E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.36|P-value:1.80E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.42|P-value:5.33E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.30|P-value:8.92E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.28|P-value:8.37E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.40|P-value:6.34E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.61|P-value:3.09E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_1606|Compound:st000094|FD-Score:4.22|P-value:3.11E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.47|P-value:5.13E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.39|P-value:6.68E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.43|P-value:5.76E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-3.35|P-value:6.67E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.68|P-value:2.44E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:5.01|P-value:1.02E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.39|P-value:5.86E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.08|P-value:7.23E-7 ID:SGTC_2382|Compound:9035899|FD-Score:3.36|P-value:7.19E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.82|P-value:1.48E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.92|P-value:8.95E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.07|P-value:5.65E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.33|P-value:8.12E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.44|P-value:5.64E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.52|P-value:4.21E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.64|P-value:2.82E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.56|P-value:3.34E-4 ID:SGTC_2957|Compound:9076800|FD-Score:6.44|P-value:4.74E-10 ID:SGTC_2967|Compound:9089538|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.30|P-value:8.74E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.41|P-value:1.46E-5 ID:SGTC_3136|Compound:9095672|FD-Score:-3.49|P-value:4.23E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.71|P-value:2.22E-4

Top fitness defect scores for YDL130W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2957 9076800 6.44 11.5 µM 4.74E-10 4 5.89E-11
2 SGTC_2276 7947513 5.08 42.1 µM 7.23E-7 10 1.91E-7
3 SGTC_2247 cerulenin 5.01 830.0 nM 1.02E-6 5 2.79E-7
4 SGTC_685 1278-0033 4.64 54.9 µM 5.29E-6 60S ribosome export 11 1.72E-6
5 SGTC_3108 9121785 4.41 49.5 µM 1.46E-5 6 5.25E-6
6 SGTC_1020 4335-0961 4.36 93.3 µM 1.80E-5 8 6.60E-6
7 SGTC_671 0560-0003 4.23 407.0 µM 3.05E-5 8 1.18E-5
8 SGTC_1606 st000094 4.22 49.2 µM 3.11E-5 60S ribosome export 11 1.21E-5
9 SGTC_930 2810-3379 4.21 265.0 µM 3.27E-5 10 1.28E-5
10 SGTC_194 1486-1323 4.17 56.9 µM 3.90E-5 14 1.55E-5
11 SGTC_683 panaxydol 4.11 45.0 µM 4.79E-5 sphingolipid biosynthesis & PDR1 36 1.95E-5
12 SGTC_2464 5717415 4.07 7.7 µM 5.65E-5 14 2.33E-5
13 SGTC_673 1082-0474 4.07 110.0 µM 5.74E-5 RSC complex & mRNA processing 60 2.37E-5
14 SGTC_841 0251-0215 3.95 91.2 µM 8.99E-5 73 3.90E-5
15 SGTC_2393 9031399 3.82 185.9 µM 1.48E-4 RNA processing & uracil transport 30 6.74E-5
16 SGTC_2202 7226349 3.81 200.0 µM 1.53E-4 7 7.01E-5
17 SGTC_391 gliotoxin 3.71 8.3 µM 2.16E-4 73 1.02E-4
18 SGTC_3180 9109287 3.71 49.5 µM 2.22E-4 18 1.05E-4
19 SGTC_311 1315-0136 3.69 58.0 µM 2.35E-4 12 1.12E-4
20 SGTC_2239 6685329 3.68 187.6 µM 2.44E-4 37 1.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.36E-9 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.095 3.74E-8 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.94E-7 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.086 5.47E-7 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.080 3.28E-6 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.078 5.83E-6 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.077 7.24E-6 YKR082W NUP133 hom Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133
0.076 9.53E-6 YGL034C_d YGL034C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 5.65E-5 YIR019C FLO11 hom GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain
0.066 1.20E-4 YDR168W CDC37 het Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
0.066 1.31E-4 YDL124W YDL124W hom NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress
0.064 2.05E-4 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.064 2.34E-4 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.063 2.53E-4 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.063 2.49E-4 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation