YDL136W / RPL35B

Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL136W / RPL35B

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.50|P-value:1.64E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.57|P-value:1.42E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.88|P-value:2.60E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.45|P-value:3.26E-5 ID:SGTC_57|Compound:miconazole|FD-Score:8.38|P-value:7.37E-15 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.98|P-value:2.89E-13 ID:SGTC_146|Compound:3448-8650|FD-Score:5.87|P-value:3.23E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:3.72|P-value:2.81E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.55|P-value:1.33E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.65|P-value:3.54E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.33|P-value:5.96E-9 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.76|P-value:3.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.32|P-value:1.91E-11 ID:SGTC_505|Compound:gw-5074|FD-Score:6.57|P-value:7.79E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:6.02|P-value:1.51E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.46|P-value:0.00100 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.57|P-value:1.24E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.63|P-value:5.92E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.83|P-value:1.92E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.05|P-value:8.87E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.48|P-value:9.43E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.73|P-value:2.77E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.77|P-value:2.43E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.78|P-value:2.28E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.36|P-value:9.19E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.36|P-value:9.04E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-4.08|P-value:1.26E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.19|P-value:8.53E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.72|P-value:4.33E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.50|P-value:1.64E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.22|P-value:7.26E-7 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.21|P-value:4.91E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.60|P-value:6.46E-10 ID:SGTC_1287|Compound:0971-0001|FD-Score:8.77|P-value:4.13E-16 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.52|P-value:5.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.44|P-value:7.12E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.71|P-value:4.54E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.46|P-value:6.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.77|P-value:9.07E-6 ID:SGTC_1712|Compound:st032288|FD-Score:12.20|P-value:3.02E-29 ID:SGTC_1768|Compound:st044301|FD-Score:3.79|P-value:2.26E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-5.62|P-value:2.10E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:-8.29|P-value:3.36E-14 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.78|P-value:5.09E-6 ID:SGTC_2138|Compound:5575593|FD-Score:-3.98|P-value:1.85E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-4.16|P-value:9.60E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.36|P-value:9.13E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.53|P-value:5.33E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.78|P-value:2.27E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.51|P-value:1.56E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-6.52|P-value:2.06E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.91|P-value:5.14E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.03|P-value:9.53E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.69|P-value:3.16E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.52|P-value:3.37E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.68|P-value:8.29E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.58|P-value:4.55E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.53|P-value:1.73E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.73|P-value:4.29E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.39|P-value:8.15E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.93|P-value:1.38E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.52|P-value:5.43E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.02|P-value:1.00E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.58|P-value:4.49E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.52|P-value:5.45E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-5.87|P-value:6.32E-8 ID:SGTC_2913|Compound:7966556|FD-Score:-3.69|P-value:4.80E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.94|P-value:1.33E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.56|P-value:7.26E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.62|P-value:6.08E-4 ID:SGTC_2962|Compound:9082311|FD-Score:5.97|P-value:1.90E-8 ID:SGTC_2983|Compound:9022671|FD-Score:3.42|P-value:7.50E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.27|P-value:3.89E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.83|P-value:7.26E-6 ID:SGTC_3301|Compound:9125354|FD-Score:-3.57|P-value:7.06E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.98|P-value:1.81E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.58|P-value:4.54E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.91|P-value:1.45E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-5.31|P-value:9.02E-7 ID:SGTC_3354|Compound:9151612|FD-Score:3.44|P-value:7.10E-4 ID:SGTC_3355|Compound:9151058|FD-Score:4.89|P-value:3.17E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:4.50|P-value:1.64E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.57|P-value:1.42E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.88|P-value:2.60E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.45|P-value:3.26E-5 ID:SGTC_57|Compound:miconazole|FD-Score:8.38|P-value:7.37E-15 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.98|P-value:2.89E-13 ID:SGTC_146|Compound:3448-8650|FD-Score:5.87|P-value:3.23E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:3.72|P-value:2.81E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.55|P-value:1.33E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.65|P-value:3.54E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.33|P-value:5.96E-9 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.76|P-value:3.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.32|P-value:1.91E-11 ID:SGTC_505|Compound:gw-5074|FD-Score:6.57|P-value:7.79E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:6.02|P-value:1.51E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.46|P-value:0.00100 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.57|P-value:1.24E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.63|P-value:5.92E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.83|P-value:1.92E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.05|P-value:8.87E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.48|P-value:9.43E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.73|P-value:2.77E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.77|P-value:2.43E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.78|P-value:2.28E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.36|P-value:9.19E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.36|P-value:9.04E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-4.08|P-value:1.26E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.19|P-value:8.53E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.72|P-value:4.33E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.50|P-value:1.64E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.22|P-value:7.26E-7 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.21|P-value:4.91E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.60|P-value:6.46E-10 ID:SGTC_1287|Compound:0971-0001|FD-Score:8.77|P-value:4.13E-16 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.52|P-value:5.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.44|P-value:7.12E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.71|P-value:4.54E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.46|P-value:6.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.77|P-value:9.07E-6 ID:SGTC_1712|Compound:st032288|FD-Score:12.20|P-value:3.02E-29 ID:SGTC_1768|Compound:st044301|FD-Score:3.79|P-value:2.26E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-5.62|P-value:2.10E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:-8.29|P-value:3.36E-14 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.78|P-value:5.09E-6 ID:SGTC_2138|Compound:5575593|FD-Score:-3.98|P-value:1.85E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-4.16|P-value:9.60E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.36|P-value:9.13E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.53|P-value:5.33E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.78|P-value:2.27E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.51|P-value:1.56E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-6.52|P-value:2.06E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.91|P-value:5.14E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.03|P-value:9.53E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.69|P-value:3.16E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.52|P-value:3.37E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.68|P-value:8.29E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.58|P-value:4.55E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.53|P-value:1.73E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.73|P-value:4.29E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.39|P-value:8.15E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.93|P-value:1.38E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.52|P-value:5.43E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.02|P-value:1.00E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.58|P-value:4.49E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.52|P-value:5.45E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-5.87|P-value:6.32E-8 ID:SGTC_2913|Compound:7966556|FD-Score:-3.69|P-value:4.80E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.94|P-value:1.33E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.56|P-value:7.26E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.62|P-value:6.08E-4 ID:SGTC_2962|Compound:9082311|FD-Score:5.97|P-value:1.90E-8 ID:SGTC_2983|Compound:9022671|FD-Score:3.42|P-value:7.50E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.27|P-value:3.89E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.83|P-value:7.26E-6 ID:SGTC_3301|Compound:9125354|FD-Score:-3.57|P-value:7.06E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.98|P-value:1.81E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.58|P-value:4.54E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.91|P-value:1.45E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-5.31|P-value:9.02E-7 ID:SGTC_3354|Compound:9151612|FD-Score:3.44|P-value:7.10E-4 ID:SGTC_3355|Compound:9151058|FD-Score:4.89|P-value:3.17E-6

Top fitness defect scores for YDL136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1712 st032288 12.20 53.4 µM 3.02E-29 calcium & mitochondrial duress 9 1.65E-34
2 SGTC_1287 0971-0001 8.77 34.6 µM 4.13E-16 sphingolipid biosynthesis & PDR1 14 8.59E-19
3 SGTC_57 miconazole 8.38 162.5 nM 7.37E-15 ergosterol depletion effects on membrane 3 2.68E-17
4 SGTC_1282 0886-0010 6.60 32.4 µM 6.46E-10 endomembrane recycling 7 2.08E-11
5 SGTC_505 gw-5074 6.57 63.9 µM 7.79E-10 23 2.60E-11
6 SGTC_528 3492-0019 6.02 172.0 µM 1.51E-8 calcium & mitochondrial duress 122 8.84E-10
7 SGTC_2962 9082311 5.97 13.2 µM 1.90E-8 3 1.16E-9
8 SGTC_146 3448-8650 5.87 53.1 µM 3.23E-8 NEO1-PIK1 56 2.17E-9
9 SGTC_2688 kanamycin b 5.68 96.7 µM 8.29E-8 calcium & mitochondrial duress 184 6.65E-9
10 SGTC_43 0570-0105 5.57 72.5 µM 1.42E-7 ERG2 44 1.26E-8
11 SGTC_2754 granisetron 5.53 64.0 µM 1.73E-7 12 1.59E-8
12 SGTC_1072 oxiconazole 5.22 14.9 nM 7.26E-7 ergosterol depletion effects on membrane 31 8.71E-8
13 SGTC_3355 9151058 4.89 44.0 µM 3.17E-6 RNA processing & uracil transport 4 4.98E-7
14 SGTC_1987 st072290 4.78 61.9 µM 5.09E-6 5 8.72E-7
15 SGTC_742 0kpi-0133 4.57 140.0 µM 1.24E-5 ERG2 12 2.49E-6
16 SGTC_167 3672-0051 4.55 66.2 µM 1.33E-5 29 2.72E-6
17 SGTC_2412 st077135 4.51 33.4 µM 1.56E-5 14 3.28E-6
18 SGTC_1011 4112-3381 4.50 17.4 µM 1.64E-5 25 3.47E-6
19 SGTC_15 0266-0086 4.50 27.1 µM 1.64E-5 endomembrane recycling 45 3.47E-6
20 SGTC_2994 9053520 4.27 71.4 µM 3.89E-5 RPP1 & pyrimidine depletion 18 9.62E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 5.96E-40 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.216 1.38E-36 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.210 9.52E-35 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.210 1.45E-34 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.206 2.31E-33 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.199 2.39E-31 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.191 9.46E-29 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.187 7.17E-28 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.183 9.06E-27 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.183 9.39E-27 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.182 2.08E-26 YDR156W RPA14 hom RNA polymerase I subunit A14
0.175 1.53E-24 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.173 5.23E-24 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.166 3.87E-22 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.164 9.85E-22 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant