YDL141W / BPL1

Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL141W / BPL1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:2.80|P-value:7.63E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:2.74|P-value:9.32E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.75|P-value:9.12E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.84|P-value:6.63E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.59|P-value:9.61E-8 ID:SGTC_358|Compound:0075-0058|FD-Score:3.77|P-value:9.76E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:-2.88|P-value:5.35E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.26|P-value:1.07E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:2.79|P-value:7.69E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:-3.29|P-value:9.55E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.86|P-value:5.89E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.66|P-value:1.65E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.53|P-value:3.08E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:5.08|P-value:4.15E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:-2.81|P-value:7.25E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.03|P-value:3.00E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.99|P-value:3.50E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:2.88|P-value:5.57E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-2.85|P-value:6.20E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:2.73|P-value:9.79E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.90|P-value:5.02E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.85|P-value:6.11E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.77|P-value:3.10E-8 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.08|P-value:2.43E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-2.80|P-value:7.52E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.74|P-value:9.64E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.66|P-value:1.67E-5 ID:SGTC_1901|Compound:st060216|FD-Score:2.77|P-value:8.40E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-2.78|P-value:8.19E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.61|P-value:2.13E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.75|P-value:1.09E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.94|P-value:3.93E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.04|P-value:2.81E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.34|P-value:7.54E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.82|P-value:7.53E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.45|P-value:4.63E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.77|P-value:3.21E-8 ID:SGTC_2781|Compound:5567276|FD-Score:-3.95|P-value:3.71E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-3.34|P-value:7.55E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-2.74|P-value:9.24E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.47|P-value:4.13E-5 ID:SGTC_2888|Compound:9058547|FD-Score:2.92|P-value:4.64E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.14|P-value:1.87E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.99|P-value:3.10E-6 ID:SGTC_3264|Compound:9137442|FD-Score:2.97|P-value:3.87E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.31|P-value:8.81E-5 ID:SGTC_3325|Compound:9138760|FD-Score:-3.63|P-value:1.88E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:2.80|P-value:7.63E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:2.74|P-value:9.32E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.75|P-value:9.12E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.84|P-value:6.63E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.59|P-value:9.61E-8 ID:SGTC_358|Compound:0075-0058|FD-Score:3.77|P-value:9.76E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:-2.88|P-value:5.35E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.26|P-value:1.07E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:2.79|P-value:7.69E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:-3.29|P-value:9.55E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.86|P-value:5.89E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.66|P-value:1.65E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.53|P-value:3.08E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:5.08|P-value:4.15E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:-2.81|P-value:7.25E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.03|P-value:3.00E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.99|P-value:3.50E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:2.88|P-value:5.57E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-2.85|P-value:6.20E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:2.73|P-value:9.79E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.90|P-value:5.02E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.85|P-value:6.11E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.77|P-value:3.10E-8 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.08|P-value:2.43E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-2.80|P-value:7.52E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.74|P-value:9.64E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.66|P-value:1.67E-5 ID:SGTC_1901|Compound:st060216|FD-Score:2.77|P-value:8.40E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-2.78|P-value:8.19E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.61|P-value:2.13E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.75|P-value:1.09E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.94|P-value:3.93E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.04|P-value:2.81E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.34|P-value:7.54E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.82|P-value:7.53E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.45|P-value:4.63E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.77|P-value:3.21E-8 ID:SGTC_2781|Compound:5567276|FD-Score:-3.95|P-value:3.71E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-3.34|P-value:7.55E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-2.74|P-value:9.24E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.47|P-value:4.13E-5 ID:SGTC_2888|Compound:9058547|FD-Score:2.92|P-value:4.64E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.14|P-value:1.87E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.99|P-value:3.10E-6 ID:SGTC_3264|Compound:9137442|FD-Score:2.97|P-value:3.87E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.31|P-value:8.81E-5 ID:SGTC_3325|Compound:9138760|FD-Score:-3.63|P-value:1.88E-5

Top fitness defect scores for YDL141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_826 1683-5028 5.08 118.0 µM 4.15E-9 1 1.87E-7 0.86
2 SGTC_1164 k060-0068 4.77 93.7 µM 3.10E-8 1 9.03E-7 0.52
3 SGTC_2565 isoliquiritigenin 4.77 100.0 µM 3.21E-8 4 9.30E-7 0.17
4 SGTC_265 mycophenolic acid 4.59 32.9 µM 9.61E-8 RPP1 & pyrimidine depletion 3 2.19E-6 0.14
5 SGTC_3049 9092223 3.99 49.5 µM 3.10E-6 4 3.36E-5 0.20
6 SGTC_2020 4017018 3.94 200.0 µM 3.93E-6 8 4.04E-5 0.25
7 SGTC_175 3793-3120 3.84 23.7 µM 6.63E-6 8 6.11E-5 0.01
8 SGTC_2290 7904846 3.82 200.0 µM 7.53E-6 17 6.75E-5 0.01
9 SGTC_358 0075-0058 3.77 9.4 µM 9.76E-6 2 8.28E-5 0.09
10 SGTC_1972 st070201 3.75 17.4 µM 1.09E-5 4 9.01E-5 0.63
11 SGTC_816 0325-0417 3.66 81.3 µM 1.65E-5 7 1.25E-4 0.07
12 SGTC_1889 st059080 3.66 5.2 µM 1.67E-5 6 1.26E-4 0.37
13 SGTC_1968 st069590 3.61 43.6 µM 2.13E-5 17 1.53E-4 0.06
14 SGTC_817 1391-0715 3.53 46.0 µM 3.08E-5 13 2.05E-4 0.04
15 SGTC_2829 7992743 3.47 58.4 µM 4.13E-5 10 2.58E-4 0.24
16 SGTC_2207 7258803 3.34 200.0 µM 7.54E-5 2 4.15E-4 0.17
17 SGTC_2932 9016711 3.14 44.5 µM 1.87E-4 19 8.50E-4 0.02
18 SGTC_1235 benzylparaben 3.08 21.5 µM 2.43E-4 8 0.00105 0.00
19 SGTC_2088 5278280 3.04 127.4 µM 2.81E-4 7 0.00117 0.21
20 SGTC_933 2914-0560 3.03 114.0 µM 3.00E-4 16 0.00123 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.43E-9 YHR196W UTP9 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.099 7.69E-9 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.095 4.00E-8 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.091 1.11E-7 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.090 1.76E-7 YJR141W_p YJR141W_p het Essential protein of unknown function
0.090 1.94E-7 YNL010W_p YNL010W_p hom Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
0.090 1.99E-7 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.087 4.75E-7 YBR188C NTC20 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.085 7.66E-7 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.41E-6 YGL044C RNA15 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.081 2.35E-6 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.080 3.18E-6 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.079 4.44E-6 YIL020C HIS6 hom Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.079 5.07E-6 YPL183C RTT10 hom WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
0.079 5.18E-6 YKL003C MRP17 hom Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator