YDL142C / CRD1

Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL142C / CRD1

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.83|P-value:3.71E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.23|P-value:3.89E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.10|P-value:9.66E-56 ID:SGTC_310|Compound:1273-0058|FD-Score:3.62|P-value:8.99E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.75|P-value:5.22E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.55|P-value:1.20E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.18|P-value:4.80E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:7.42|P-value:7.28E-15 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.55|P-value:1.12E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.18|P-value:7.52E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.57|P-value:1.03E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.11|P-value:1.03E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.17|P-value:5.27E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.14|P-value:5.47E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.48|P-value:6.88E-9 ID:SGTC_907|Compound:3448-6986|FD-Score:4.24|P-value:5.73E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.88|P-value:5.62E-10 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.47|P-value:1.62E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.24|P-value:2.83E-8 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.01|P-value:9.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.00|P-value:2.64E-10 ID:SGTC_1748|Compound:st037455|FD-Score:3.63|P-value:8.68E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.27|P-value:3.39E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.09|P-value:6.84E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.42|P-value:1.92E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.28|P-value:3.26E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.32|P-value:1.81E-8 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.10|P-value:6.77E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.08|P-value:6.89E-4 ID:SGTC_2849|Compound:9019321|FD-Score:8.56|P-value:3.79E-19 ID:SGTC_2857|Compound:9024691|FD-Score:3.80|P-value:4.13E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-5.66|P-value:2.04E-9 ID:SGTC_2870|Compound:9038528|FD-Score:-2.99|P-value:9.34E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.08|P-value:7.27E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.64|P-value:7.84E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.45|P-value:1.69E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.27|P-value:3.61E-4 ID:SGTC_2913|Compound:7966556|FD-Score:5.26|P-value:2.53E-8 ID:SGTC_3037|Compound:9091026|FD-Score:5.37|P-value:1.38E-8 ID:SGTC_3082|Compound:9117008|FD-Score:3.07|P-value:7.42E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.39|P-value:2.79E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.87|P-value:3.06E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-3.17|P-value:4.94E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.08|P-value:7.22E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.83|P-value:3.71E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.23|P-value:3.89E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.10|P-value:9.66E-56 ID:SGTC_310|Compound:1273-0058|FD-Score:3.62|P-value:8.99E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.75|P-value:5.22E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.55|P-value:1.20E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.18|P-value:4.80E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:7.42|P-value:7.28E-15 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.55|P-value:1.12E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.18|P-value:7.52E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.57|P-value:1.03E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.11|P-value:1.03E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.17|P-value:5.27E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.14|P-value:5.47E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:5.48|P-value:6.88E-9 ID:SGTC_907|Compound:3448-6986|FD-Score:4.24|P-value:5.73E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.88|P-value:5.62E-10 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.47|P-value:1.62E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.24|P-value:2.83E-8 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.01|P-value:9.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.00|P-value:2.64E-10 ID:SGTC_1748|Compound:st037455|FD-Score:3.63|P-value:8.68E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.27|P-value:3.39E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.09|P-value:6.84E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.42|P-value:1.92E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.28|P-value:3.26E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.32|P-value:1.81E-8 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.10|P-value:6.77E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.08|P-value:6.89E-4 ID:SGTC_2849|Compound:9019321|FD-Score:8.56|P-value:3.79E-19 ID:SGTC_2857|Compound:9024691|FD-Score:3.80|P-value:4.13E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-5.66|P-value:2.04E-9 ID:SGTC_2870|Compound:9038528|FD-Score:-2.99|P-value:9.34E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.08|P-value:7.27E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.64|P-value:7.84E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.45|P-value:1.69E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.27|P-value:3.61E-4 ID:SGTC_2913|Compound:7966556|FD-Score:5.26|P-value:2.53E-8 ID:SGTC_3037|Compound:9091026|FD-Score:5.37|P-value:1.38E-8 ID:SGTC_3082|Compound:9117008|FD-Score:3.07|P-value:7.42E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.39|P-value:2.79E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.87|P-value:3.06E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-3.17|P-value:4.94E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.08|P-value:7.22E-4

Top fitness defect scores for YDL142C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.10 5.3 µM 9.66E-56 99 4.95E-52
2 SGTC_2849 9019321 8.56 13.0 µM 3.79E-19 3 5.77E-18
3 SGTC_455 paf C-16 7.42 10.0 µM 7.28E-15 4 5.66E-14
4 SGTC_1635 st007035 6.00 42.4 µM 2.64E-10 137 1.01E-9
5 SGTC_915 methyl methanesulfonate (MMS) 5.88 110.0 mM 5.62E-10 DNA damage response 11 2.04E-9
6 SGTC_873 0591-4978 5.48 488.0 µM 6.88E-9 5 2.11E-8
7 SGTC_3037 9091026 5.37 49.5 µM 1.38E-8 NEO1-PIK1 60 4.03E-8
8 SGTC_2306 7482397 5.32 179.5 µM 1.81E-8 RPP1 & pyrimidine depletion 5 5.19E-8
9 SGTC_2913 7966556 5.26 36.6 µM 2.53E-8 60S ribosome export 3 7.11E-8
10 SGTC_1085 doxorubicin 5.24 7.7 µM 2.83E-8 anthracycline transcription coupled DNA repair 2 7.90E-8
11 SGTC_3147 9097027 4.39 49.5 µM 2.79E-6 9 5.74E-6
12 SGTC_907 3448-6986 4.24 75.5 µM 5.73E-6 21 1.12E-5
13 SGTC_545 4218-0007 4.18 221.0 µM 7.52E-6 21 1.45E-5
14 SGTC_772 k072-0172 4.11 35.3 µM 1.03E-5 16 1.95E-5
15 SGTC_3221 9128209 3.87 49.5 µM 3.06E-5 16 5.37E-5
16 SGTC_81 0411-0046 3.83 10.0 µM 3.71E-5 27 6.44E-5
17 SGTC_2857 9024691 3.80 58.4 µM 4.13E-5 25 7.12E-5
18 SGTC_365 0121-0052 3.75 13.6 µM 5.22E-5 mitochondrial response to ROS 62 8.86E-5
19 SGTC_1748 st037455 3.63 53.6 µM 8.68E-5 41 1.43E-4
20 SGTC_310 1273-0058 3.62 1.1 µM 8.99E-5 mitochondrial stress 269 1.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.444 1.21E-161 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.433 1.33E-153 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.431 1.35E-151 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.426 5.05E-148 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.425 2.80E-147 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.417 2.28E-141 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.411 4.45E-137 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.402 2.95E-130 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.401 3.57E-130 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.389 1.20E-121 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.388 1.24E-120 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.382 5.86E-117 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.373 1.47E-111 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.367 3.55E-107 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.366 5.80E-107 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies