YDL143W / CCT4

Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL143W / CCT4

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-4.61|P-value:2.98E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:8.39|P-value:3.25E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:4.70|P-value:2.81E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.97|P-value:1.31E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:5.75|P-value:1.20E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:6.19|P-value:2.66E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:6.23|P-value:2.35E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:7.74|P-value:6.19E-9 ID:SGTC_258|Compound:haloperidol|FD-Score:4.39|P-value:6.37E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.73|P-value:2.89E-7 ID:SGTC_375|Compound:3970-0961|FD-Score:6.02|P-value:4.82E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-4.37|P-value:5.67E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.84|P-value:1.58E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-4.75|P-value:2.08E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-7.52|P-value:1.19E-8 ID:SGTC_541|Compound:4513-1321|FD-Score:5.19|P-value:6.94E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:5.44|P-value:3.28E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:5.82|P-value:9.47E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:-6.29|P-value:1.50E-6 ID:SGTC_698|Compound:k064-0052|FD-Score:4.73|P-value:2.62E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.93|P-value:6.68E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.79|P-value:1.83E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.26|P-value:9.02E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.79|P-value:2.21E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.26|P-value:8.93E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.40|P-value:6.19E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.38|P-value:6.52E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.62|P-value:3.52E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.64|P-value:1.69E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.35|P-value:6.04E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.86|P-value:1.79E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.30|P-value:6.88E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:-5.38|P-value:3.16E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:7.64|P-value:9.59E-9 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:6.56|P-value:7.01E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.00|P-value:1.22E-4 ID:SGTC_1643|Compound:st009866|FD-Score:7.33|P-value:3.43E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:13.70|P-value:2.44E-24 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.20|P-value:6.67E-5 ID:SGTC_2005|Compound:4024620|FD-Score:6.34|P-value:1.57E-6 ID:SGTC_2050|Compound:5263056|FD-Score:4.57|P-value:4.02E-4 ID:SGTC_2174|Compound:5790901|FD-Score:5.26|P-value:5.54E-5 ID:SGTC_2214|Compound:7179297|FD-Score:4.49|P-value:4.97E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.11|P-value:8.78E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.87|P-value:1.76E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-4.44|P-value:4.76E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.47|P-value:5.24E-4 ID:SGTC_2710|Compound:st078562|FD-Score:5.06|P-value:1.02E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.52|P-value:4.62E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.62|P-value:1.46E-5 ID:SGTC_2838|Compound:9002687|FD-Score:7.80|P-value:4.75E-9 ID:SGTC_2907|Compound:7721985|FD-Score:6.65|P-value:5.12E-7 ID:SGTC_2993|Compound:9054257|FD-Score:6.54|P-value:7.55E-7 ID:SGTC_3003|Compound:9075612|FD-Score:5.21|P-value:6.51E-5 ID:SGTC_3147|Compound:9097027|FD-Score:-5.68|P-value:1.24E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.62|P-value:2.93E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-4.67|P-value:2.53E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.61|P-value:2.98E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:8.39|P-value:3.25E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:4.70|P-value:2.81E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.97|P-value:1.31E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:5.75|P-value:1.20E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:6.19|P-value:2.66E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:6.23|P-value:2.35E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:7.74|P-value:6.19E-9 ID:SGTC_258|Compound:haloperidol|FD-Score:4.39|P-value:6.37E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.73|P-value:2.89E-7 ID:SGTC_375|Compound:3970-0961|FD-Score:6.02|P-value:4.82E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-4.37|P-value:5.67E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.84|P-value:1.58E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-4.75|P-value:2.08E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-7.52|P-value:1.19E-8 ID:SGTC_541|Compound:4513-1321|FD-Score:5.19|P-value:6.94E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:5.44|P-value:3.28E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:5.82|P-value:9.47E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:-6.29|P-value:1.50E-6 ID:SGTC_698|Compound:k064-0052|FD-Score:4.73|P-value:2.62E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.93|P-value:6.68E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.79|P-value:1.83E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.26|P-value:9.02E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.79|P-value:2.21E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.26|P-value:8.93E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.40|P-value:6.19E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.38|P-value:6.52E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.62|P-value:3.52E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.64|P-value:1.69E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.35|P-value:6.04E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.86|P-value:1.79E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.30|P-value:6.88E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:-5.38|P-value:3.16E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:7.64|P-value:9.59E-9 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:6.56|P-value:7.01E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.00|P-value:1.22E-4 ID:SGTC_1643|Compound:st009866|FD-Score:7.33|P-value:3.43E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:13.70|P-value:2.44E-24 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.20|P-value:6.67E-5 ID:SGTC_2005|Compound:4024620|FD-Score:6.34|P-value:1.57E-6 ID:SGTC_2050|Compound:5263056|FD-Score:4.57|P-value:4.02E-4 ID:SGTC_2174|Compound:5790901|FD-Score:5.26|P-value:5.54E-5 ID:SGTC_2214|Compound:7179297|FD-Score:4.49|P-value:4.97E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.11|P-value:8.78E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.87|P-value:1.76E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-4.44|P-value:4.76E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.47|P-value:5.24E-4 ID:SGTC_2710|Compound:st078562|FD-Score:5.06|P-value:1.02E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.52|P-value:4.62E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.62|P-value:1.46E-5 ID:SGTC_2838|Compound:9002687|FD-Score:7.80|P-value:4.75E-9 ID:SGTC_2907|Compound:7721985|FD-Score:6.65|P-value:5.12E-7 ID:SGTC_2993|Compound:9054257|FD-Score:6.54|P-value:7.55E-7 ID:SGTC_3003|Compound:9075612|FD-Score:5.21|P-value:6.51E-5 ID:SGTC_3147|Compound:9097027|FD-Score:-5.68|P-value:1.24E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.62|P-value:2.93E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-4.67|P-value:2.53E-4

Top fitness defect scores for YDL143W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 13.70 6.0 µM 2.44E-24 tubulin folding & SWR complex 6 3.89E-43 0.39
2 SGTC_66 0109-0187 8.39 42.4 µM 3.25E-10 2 2.35E-17 2.62
3 SGTC_2838 9002687 7.80 71.4 µM 4.75E-9 fatty acid desaturase (OLE1) 2 3.08E-15 1.05
4 SGTC_212 3807-4682 7.74 38.8 µM 6.19E-9 tubulin folding & SWR complex 8 4.97E-15 0.60
5 SGTC_1511 0906-3109 7.64 28.5 µM 9.59E-9 excess fatty acid 1 1.10E-14 1.53
6 SGTC_1643 st009866 7.33 20.2 µM 3.43E-8 6 1.11E-13 0.12
7 SGTC_2907 7721985 6.65 69.9 µM 5.12E-7 1 1.49E-11 2.44
8 SGTC_1517 deoxycholic acid methyl ester 6.56 49.2 µM 7.01E-7 1 2.64E-11 2.09
9 SGTC_2993 9054257 6.54 71.4 µM 7.55E-7 fatty acid desaturase (OLE1) 9 3.02E-11 0.39
10 SGTC_2005 4024620 6.34 188.0 µM 1.57E-6 1 1.13E-10 1.43
11 SGTC_115 0527-0192 6.23 112.0 µM 2.35E-6 3 2.36E-10 0.89
12 SGTC_104 0074-0074 6.19 591.0 µM 2.66E-6 3 2.94E-10 0.02
13 SGTC_375 3970-0961 6.02 9.3 µM 4.82E-6 tubulin folding & SWR complex 3 8.62E-10 0.62
14 SGTC_721 1187-1332 5.93 279.0 µM 6.68E-6 cell wall signaling 2 1.55E-9 0.36
15 SGTC_653 0203-0016 5.82 55.2 µM 9.47E-6 1 2.91E-9 0.78
16 SGTC_76 0433-0009 5.75 400.3 µM 1.20E-5 1 4.49E-9 0.53
17 SGTC_1282 0886-0010 5.64 32.4 µM 1.69E-5 endomembrane recycling 5 8.28E-9 0.43
18 SGTC_650 1328-0195 5.44 38.0 µM 3.28E-5 1 2.74E-8 1.57
19 SGTC_2174 5790901 5.26 200.0 µM 5.54E-5 tubulin folding & SWR complex 6 7.01E-8 0.02
20 SGTC_3003 9075612 5.21 71.4 µM 6.51E-5 2 9.38E-8 0.58

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.308 1.65E-74 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.294 6.15E-68 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.290 5.75E-66 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.273 1.56E-58 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.270 3.04E-57 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.267 8.34E-56 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.256 1.81E-51 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.235 1.74E-43 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.224 1.50E-39 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.182 1.96E-26 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.181 4.86E-26 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.159 2.34E-20 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.158 3.66E-20 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.155 1.62E-19 YLR197W NOP56 het Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
0.148 7.32E-18 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2