YDL145C / COP1

Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL145C / COP1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.22|P-value:4.49E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.70|P-value:5.86E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.41|P-value:2.24E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.12|P-value:1.08E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.44|P-value:1.96E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.45|P-value:1.79E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.04|P-value:1.44E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:6.62|P-value:3.65E-12 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.12|P-value:2.30E-17 ID:SGTC_301|Compound:4119-0100|FD-Score:3.68|P-value:7.00E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.41|P-value:1.22E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.08|P-value:7.64E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.23|P-value:4.36E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.03|P-value:8.34E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.44|P-value:1.95E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.16|P-value:5.23E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:5.11|P-value:6.31E-8 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.21|P-value:4.74E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.34|P-value:2.70E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:6.74|P-value:1.55E-12 ID:SGTC_1149|Compound:3909-7961|FD-Score:6.99|P-value:2.39E-13 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.59|P-value:4.50E-12 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.17|P-value:5.51E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.02|P-value:1.59E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.69|P-value:7.05E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.34|P-value:3.51E-6 ID:SGTC_1740|Compound:st038286|FD-Score:4.80|P-value:3.40E-7 ID:SGTC_1741|Compound:st038134|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.56|P-value:1.20E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:8.94|P-value:1.14E-20 ID:SGTC_1800|Compound:st050079|FD-Score:-4.36|P-value:3.42E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-5.03|P-value:1.07E-7 ID:SGTC_1826|Compound:st055655|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.58|P-value:1.13E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.98|P-value:1.92E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.23|P-value:4.14E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.63|P-value:8.10E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.73|P-value:5.97E-5 ID:SGTC_2370|Compound:9071495|FD-Score:-3.41|P-value:2.18E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.11|P-value:6.32E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.80|P-value:4.17E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.17|P-value:5.41E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.40|P-value:2.13E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.33|P-value:2.79E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.43|P-value:1.88E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.55|P-value:1.27E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.15|P-value:5.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.14|P-value:5.78E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.67|P-value:6.53E-7 ID:SGTC_2844|Compound:9010103|FD-Score:-3.41|P-value:2.20E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.10|P-value:6.53E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.37|P-value:2.36E-4 ID:SGTC_2944|Compound:9067346|FD-Score:7.59|P-value:2.09E-15 ID:SGTC_2993|Compound:9054257|FD-Score:4.48|P-value:1.73E-6 ID:SGTC_3009|Compound:9080819|FD-Score:3.21|P-value:4.36E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.18|P-value:4.91E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.80|P-value:3.30E-7 ID:SGTC_3205|Compound:9113483|FD-Score:-3.18|P-value:5.23E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-4.21|P-value:7.22E-6 ID:SGTC_3332|Compound:9141069|FD-Score:3.14|P-value:5.75E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.62|P-value:8.85E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.00|P-value:9.23E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.22|P-value:4.49E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.70|P-value:5.86E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.41|P-value:2.24E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.12|P-value:1.08E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.44|P-value:1.96E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.45|P-value:1.79E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.04|P-value:1.44E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:6.62|P-value:3.65E-12 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.12|P-value:2.30E-17 ID:SGTC_301|Compound:4119-0100|FD-Score:3.68|P-value:7.00E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.41|P-value:1.22E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.08|P-value:7.64E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.23|P-value:4.36E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.03|P-value:8.34E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.44|P-value:1.95E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.16|P-value:5.23E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:5.11|P-value:6.31E-8 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.21|P-value:4.74E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.34|P-value:2.70E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:6.74|P-value:1.55E-12 ID:SGTC_1149|Compound:3909-7961|FD-Score:6.99|P-value:2.39E-13 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.59|P-value:4.50E-12 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.17|P-value:5.51E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.02|P-value:1.59E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.69|P-value:7.05E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.34|P-value:3.51E-6 ID:SGTC_1740|Compound:st038286|FD-Score:4.80|P-value:3.40E-7 ID:SGTC_1741|Compound:st038134|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.56|P-value:1.20E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:8.94|P-value:1.14E-20 ID:SGTC_1800|Compound:st050079|FD-Score:-4.36|P-value:3.42E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-5.03|P-value:1.07E-7 ID:SGTC_1826|Compound:st055655|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.58|P-value:1.13E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.98|P-value:1.92E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.23|P-value:4.14E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.63|P-value:8.10E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.73|P-value:5.97E-5 ID:SGTC_2370|Compound:9071495|FD-Score:-3.41|P-value:2.18E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.11|P-value:6.32E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.80|P-value:4.17E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.17|P-value:5.41E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.40|P-value:2.13E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.33|P-value:2.79E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.43|P-value:1.88E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.55|P-value:1.27E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.15|P-value:5.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.14|P-value:5.78E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.67|P-value:6.53E-7 ID:SGTC_2844|Compound:9010103|FD-Score:-3.41|P-value:2.20E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.10|P-value:6.53E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.37|P-value:2.36E-4 ID:SGTC_2944|Compound:9067346|FD-Score:7.59|P-value:2.09E-15 ID:SGTC_2993|Compound:9054257|FD-Score:4.48|P-value:1.73E-6 ID:SGTC_3009|Compound:9080819|FD-Score:3.21|P-value:4.36E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.18|P-value:4.91E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.80|P-value:3.30E-7 ID:SGTC_3205|Compound:9113483|FD-Score:-3.18|P-value:5.23E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-4.21|P-value:7.22E-6 ID:SGTC_3332|Compound:9141069|FD-Score:3.14|P-value:5.75E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.62|P-value:8.85E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.00|P-value:9.23E-4

Top fitness defect scores for YDL145C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1789 tunicamycin 8.94 25.0 nM 1.14E-20 unfolded protein response 5 1.90E-19 3.01
2 SGTC_255 tunicamycin 8.12 200.5 nM 2.30E-17 unfolded protein response 7 2.38E-16 1.07
3 SGTC_2944 9067346 7.59 25.6 µM 2.09E-15 1 1.62E-14 0.99
4 SGTC_1149 3909-7961 6.99 23.3 µM 2.39E-13 1 1.37E-12 2.29
5 SGTC_1143 3454-2408 6.74 5.1 µM 1.55E-12 60S ribosome export 1 7.91E-12 1.98
6 SGTC_245 methotrexate 6.62 289.6 µM 3.65E-12 6 1.77E-11 0.79
7 SGTC_1161 k007-0610 6.59 110.0 µM 4.50E-12 ERAD & cell cycle 14 2.15E-11 0.27
8 SGTC_674 0498-0004 5.11 451.0 µM 6.31E-8 heme requiring 8 1.65E-7 0.36
9 SGTC_3142 9086498 4.80 49.5 µM 3.30E-7 iron homeostasis 33 7.77E-7 0.11
10 SGTC_1740 st038286 4.80 13.2 µM 3.40E-7 3 7.99E-7 0.04
11 SGTC_45 0kpi-0036 4.70 14.9 µM 5.86E-7 excess fatty acid 6 1.33E-6 0.51
12 SGTC_2841 9004761 4.67 39.0 µM 6.53E-7 amide catabolism 6 1.47E-6 0.66
13 SGTC_1945 st075991 4.63 56.6 µM 8.10E-7 60S ribosome export 4 1.80E-6 0.03
14 SGTC_2993 9054257 4.48 71.4 µM 1.73E-6 fatty acid desaturase (OLE1) 26 3.67E-6 0.12
15 SGTC_1597 7-benzyloxygramine 4.34 47.5 µM 3.51E-6 calcium & mitochondrial duress 48 7.13E-6 0.05
16 SGTC_151 3013-0144 4.04 2.3 µM 1.44E-5 iron homeostasis 8 2.68E-5 0.14
17 SGTC_1358 1509-0022 4.02 2.5 µM 1.59E-5 6 2.94E-5 0.41
18 SGTC_1831 st055328 3.98 12.0 µM 1.92E-5 heme biosynthesis & mitochondrial translocase 13 3.52E-5 0.09
19 SGTC_2450 5739737 3.80 12.9 µM 4.17E-5 5 7.27E-5 0.08
20 SGTC_301 4119-0100 3.68 24.5 µM 7.00E-5 NEO1 9 1.18E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.351 4.04E-98 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.311 3.56E-76 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.272 8.74E-58 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.261 2.54E-53 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.180 8.16E-26 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.178 2.82E-25 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.139 7.81E-16 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.132 1.99E-14 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.132 1.72E-14 YOR112W CEX1 hom Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
0.130 4.91E-14 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
0.128 1.03E-13 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.122 1.25E-12 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.115 2.63E-11 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.115 2.84E-11 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.93E-11 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin