YDL148C / NOP14

Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL148C / NOP14

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:25.10|P-value:1.29E-133 ID:SGTC_137|Compound:0438-0332|FD-Score:4.08|P-value:3.43E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.23|P-value:2.89E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:4.78|P-value:1.59E-6 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.18|P-value:8.34E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-4.07|P-value:2.94E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.09|P-value:3.34E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.89|P-value:7.51E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.59|P-value:3.71E-6 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.37|P-value:5.25E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.24|P-value:1.55E-7 ID:SGTC_507|Compound:nimesulide|FD-Score:3.20|P-value:9.34E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.10|P-value:3.18E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.25|P-value:1.68E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:6.65|P-value:4.08E-11 ID:SGTC_589|Compound:1227-0070|FD-Score:3.54|P-value:2.81E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.22|P-value:1.80E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.49|P-value:3.37E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.21|P-value:2.06E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.38|P-value:5.06E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.95|P-value:5.94E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.44|P-value:4.10E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.64|P-value:1.96E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.73|P-value:1.39E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.11|P-value:2.50E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:22.00|P-value:1.33E-103 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.36|P-value:1.08E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.27|P-value:7.24E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.27|P-value:1.58E-5 ID:SGTC_1786|Compound:berberine|FD-Score:4.00|P-value:4.91E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.33|P-value:5.07E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.25|P-value:6.63E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.38|P-value:5.08E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.43|P-value:4.19E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.23|P-value:8.38E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.43|P-value:4.22E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.75|P-value:1.43E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.50|P-value:2.74E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.70|P-value:1.31E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.06|P-value:3.82E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.37|P-value:8.25E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.47|P-value:3.67E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.94|P-value:7.06E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.20|P-value:9.25E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-5.31|P-value:8.21E-8 ID:SGTC_3303|Compound:9125618|FD-Score:3.22|P-value:8.60E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.18|P-value:9.95E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:25.10|P-value:1.29E-133 ID:SGTC_137|Compound:0438-0332|FD-Score:4.08|P-value:3.43E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.23|P-value:2.89E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:4.78|P-value:1.59E-6 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.18|P-value:8.34E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-4.07|P-value:2.94E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.09|P-value:3.34E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.89|P-value:7.51E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.59|P-value:3.71E-6 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.37|P-value:5.25E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.24|P-value:1.55E-7 ID:SGTC_507|Compound:nimesulide|FD-Score:3.20|P-value:9.34E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.10|P-value:3.18E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.25|P-value:1.68E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:6.65|P-value:4.08E-11 ID:SGTC_589|Compound:1227-0070|FD-Score:3.54|P-value:2.81E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.22|P-value:1.80E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.49|P-value:3.37E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.21|P-value:2.06E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.38|P-value:5.06E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.95|P-value:5.94E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.44|P-value:4.10E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.64|P-value:1.96E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.73|P-value:1.39E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.11|P-value:2.50E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:22.00|P-value:1.33E-103 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.36|P-value:1.08E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.27|P-value:7.24E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.27|P-value:1.58E-5 ID:SGTC_1786|Compound:berberine|FD-Score:4.00|P-value:4.91E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.33|P-value:5.07E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.25|P-value:6.63E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.38|P-value:5.08E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.43|P-value:4.19E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.23|P-value:8.38E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.43|P-value:4.22E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.75|P-value:1.43E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.50|P-value:2.74E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.70|P-value:1.31E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.06|P-value:3.82E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.37|P-value:8.25E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.47|P-value:3.67E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.94|P-value:7.06E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.20|P-value:9.25E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-5.31|P-value:8.21E-8 ID:SGTC_3303|Compound:9125618|FD-Score:3.22|P-value:8.60E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.18|P-value:9.95E-4

Top fitness defect scores for YDL148C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_103 0844-0104 25.10 51.8 µM 1.29E-133 ERAD & cell cycle 1 3.85E-139 5.20
2 SGTC_1161 k007-0610 22.00 110.0 µM 1.33E-103 ERAD & cell cycle 1 6.80E-108 5.24
3 SGTC_568 1193-0097 6.65 7.5 µM 4.08E-11 ERAD & cell cycle 11 1.45E-11 0.25
4 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 5.24 150.0 µM 1.55E-7 Golgi 1 7.86E-8 1.29
5 SGTC_619 1652-1634 5.22 108.0 µM 1.80E-7 PDR1 3 9.18E-8 0.12
6 SGTC_2936 9038235 4.94 15.6 µM 7.06E-7 4 3.83E-7 0.90
7 SGTC_163 1327-0036 4.78 7.5 µM 1.59E-6 38 8.91E-7 0.10
8 SGTC_405 ebelactone b 4.59 50.0 µM 3.71E-6 1 2.16E-6 1.07
9 SGTC_1304 1165-0502 4.36 251.0 µM 1.08E-5 3 6.60E-6 0.18
10 SGTC_1773 st048542 4.27 73.6 µM 1.58E-5 21 9.81E-6 0.06
11 SGTC_533 1222-0222 4.25 6.7 µM 1.68E-5 PDR1 10 1.05E-5 0.05
12 SGTC_637 1181-0519 4.21 7.3 µM 2.06E-5 fatty acid desaturase (OLE1) 9 1.29E-5 0.17
13 SGTC_529 4076-0302 4.10 30.3 µM 3.18E-5 mitochondrial processes 6 2.04E-5 0.22
14 SGTC_384 k007-0144 4.09 5.2 µM 3.34E-5 ERAD & cell cycle 13 2.14E-5 0.07
15 SGTC_137 0438-0332 4.08 85.4 µM 3.43E-5 ubiquinone biosynthesis & proteasome 39 2.21E-5 0.02
16 SGTC_2754 granisetron 4.06 64.0 µM 3.82E-5 5 2.47E-5 0.10
17 SGTC_1786 berberine 4.00 21.6 µM 4.91E-5 60S ribosome export 19 3.20E-5 0.05
18 SGTC_668 1682-0499 3.95 62.6 µM 5.94E-5 4 3.91E-5 0.22
19 SGTC_404 fumagillin 3.89 50.0 µM 7.51E-5 4 5.00E-5 0.06
20 SGTC_1024 4507-0395 3.73 26.0 µM 1.39E-4 TSC3-RPN4 13 9.48E-5 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.477 1.79E-190 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.418 5.67E-142 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.397 4.12E-127 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.393 3.49E-124 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.383 1.69E-117 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.378 1.62E-114 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.366 3.81E-107 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.351 4.82E-98 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.341 3.14E-92 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.334 2.61E-88 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.332 2.89E-87 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress
0.328 5.15E-85 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.326 3.90E-84 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.325 4.27E-83 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.323 1.41E-82 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication